JPH01132511A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic cosmetic, having excellent hair tonic effects and remarkably improved low-temperature preservation stability, by combining fatty acids having an odd number of carbon chain length with a cationic surfactant and ester oil having a branched chain length which is a liquid at ordinary temperature in a specific proportion. CONSTITUTION:A hair tonic cosmetic, obtained by blending respective one or more kinds of (a) fatty acids having preferably >=9C, especially 11-25C odd number of carbon chain length (e.g., pentadecanoic acid) or a derivative thereof (e.g., mono--triglycerides) with (B) cationic surfactants, e.g., stearyltrimethylammonium chloride and (C) ester oils having a branched chain length which is a liquid at ordinary temperature, e.g., isopropyl palmitate, as essential ingredients therein and capable of producing the above-mentioned effects. The amounts of the ingredients blended are 0.1-15wt.%, preferably 0.5-5wt.% ingredient (A), 0.01-5wt.%, preferably 0.1-1.2wt.% ingredient (B) and 1-30wt.%, preferably 5-20wt.% ingredient (C).

Description

[Detailed description of the invention] [Industrial application fields] The present invention relates to an emulsion type hair nourishing cosmetic.

[Prior Art] Hair tonics containing various medicinal agents that are expected to have hair nourishing and hair growth effects have been known, and are used for the prevention and treatment of alopecia. As a medicinal agent, for example, vitamin E
Vitamins such as; amino acids such as serine and methionine; vasodilators such as acetyl colon derivatives; anti-inflammatory agents such as purple root extract; female hormones such as estradiol; skin function enhancers such as cephalanthine; copper I-tothenate Melanin synthesis catalysts such as: Keratolytic agents such as cericylic acid.

Fatty acids with odd carbon chain lengths or their derivatives have been discovered as effective medicinal ingredients that have a hair-restoring effect, and hair-restoring agents containing these as active ingredients have been proposed (Japanese Patent Laid-Open No. 59-2
7809). Furthermore, emulsification techniques for fatty acids and their derivatives have been studied for a long time and are already known.

However, it is said that the transdermal absorption of the active ingredients in emulsified hair tonics is lower than that in transparent liquid books. Also,
Depending on the chemical structure of the active ingredient, it may cause the inconvenience of aggregation or separation at low temperatures, which may further reduce the hair-nourishing effect. For commercial value, emulsified type hair nourishing agents must not cause aggregation or separation even under storage conditions ranging from a low temperature of about 15° C. in winter to a high temperature of 40° C. or more in midsummer. However, conventionally known emulsion type hair nourishing agents are still insufficient in these respects.

[Problems to be Solved by the Invention] The present invention has been made in view of the above circumstances, and provides an emulsion type hair growth composition that has an excellent hair growth effect and is significantly improved in low-temperature storage stability. The purpose is to

As a result of intensive research to achieve the above object, the present inventors found that a fatty acid having an odd carbon chain length or a predetermined derivative thereof, a predetermined cationic surfactant, a predetermined nonionic surfactant, It has been discovered that an emulsified hair-nourishing cosmetic that has an excellent hair-nourishing effect and has significantly improved storage stability at low temperatures can be obtained by combining it with a specified ester oil, and has developed the present invention. I came to do this.

That is, the hair cosmetic of the present invention contains 0 or more fatty acids having odd carbon chain lengths or predetermined derivatives thereof.
．． 1 to 15 iJ%, one or more predetermined cationic surfactants, 0.01 to 5% by weight, and one or two ester oils having a branched chain length that is liquid at room temperature. It is characterized by containing 1 to 30% by weight of the above.

The fatty acid having an odd carbon chain length used in the hair nourishing cosmetic of the present invention may be one in which the number of carbon atoms constituting the carbon chain is an odd number. Any one may be used, and in the case of an unsaturated chain, it may contain a plurality of double bonds.

The carbon chain length is preferably Fi, 9 or more, more preferably 11 to 25. Examples of such fatty acids include nonanoic acid, undecanoic acid, tridecanoic acid, pentadecanoic acid, heptadecanoic acid, nonadecanoic acid, he/eicosanoic acid, tricosanoic acid, pentacosanoic acid, and the like.

Examples of the fatty acid derivatives having an odd carbon chain length used in the hair nourishing cosmetic composition of the present invention include those shown below.

b) Below - Monoglyceride (1) indicated by pattern hole (1) or [■] CH20COR (If) CH2 (OH)
CH2(O)f) CH2(OH) where R represents a linear organic group with an even carbon chain length.

) Diglyceride indicated by the following - Monana CI) or (IV) [Otori]
(ID Here, at least one of R1 and R2 represents a linear organic group having an even carbon chain length. R1
Further, if either one of 1iR2 is a chain organic group having an even number of carbon chain lengths, the effects of the present invention will not be obtained, but the other one may be a chain organic group having an odd number of carbon chain lengths. . However, diglycerides of fatty acids of odd chain length are particularly preferred.

C) Below - triglyceride (V) indicated by the hole (V)
) CH20COR.

CH2COR2 CH20COR.

Here, at least one of R,, R, 2 and R3 represents a linear organic group having an even number of carbon chain lengths. R,,
The effects of the present invention can be obtained if at least one of R2 and R3 is a chain organic group having an even number of carbon chain lengths, and the other is a chain organic group having an odd number of carbon chain lengths. I don't mind. However, triglycerides of fatty acids of odd chain length are particularly preferred.

2) The following - Fatty acid salt represented by Monka (Vl) [■1] (RCOO)M where RVi is a linear organic group having an even carbon chain length,
M represents a metal atom, and n represents an integer corresponding to the valence of M.

A typical example is RCOONa.

RCOOK, RCOOLl, etc.

E) The following - Ester [■] represented by a pattern hole [■] RCOOR' Here, R is a linear organic group having an even number of carbon chain lengths, R
' is a monohydric or dihydric alcohol residue.

Represents an amine residue, polyoxyethylene residue, sorbitan residue, or sucrose residue. Typical examples of monohydric alcohols are methanol and ethanol, and typical examples of amine residues are mono-so-triethanolamine.

f) Below - Primary amide [I RCONR'R' represented by Monna [l] where R represents a linear organic group having an even carbon chain length. R' and R1 represent hydrogen or an organic group that does not adversely affect the human body.

g) Second amide (IX) represented by the following pattern (K) RC0NC0R2 R' Here, at least one of R1 and R2 represents a linear organic group having an even carbon chain length. If at least one of R1 and R2 is an organic group with an even chain length, the effects of the present invention can be obtained;
may be any organic group as long as it does not have an adverse effect on the human body. However, it is particularly preferred that both groups are linear organic groups with even chain lengths. R' may be hydrogen.

h) The following - tertiary amide (X) represented by Monna (X) RlCONCOR.

C.O.R.

Here, at least one of R,, R2 and R3 represents a linear organic group having an even carbon chain length. R1,
The effect of the present invention can be obtained if at least 411 of R and R5 has an even chain length, and the others can be any organic group as long as it does not give an adverse effect II' on the human body. It may be a base.

However, it is particularly preferable that all three of these groups are straight-chain organic groups with even chain lengths.

) Dibasic acids and their salts represented by the following - HOOCRCOOH (XI) Here, R represents a linear organic group containing an odd number of carbon chain lengths.

n) Below - Sterol ester represented by Monana [Kari] [Kari] Here, R represents a linear organic group having an even carbon chain length.

) Below - Phospholipid represented by a hole [■] [■] CH20COR.

(2) CH2COR2 Here, R1 and R2 are chain organic groups, and at least one of them, particularly preferably both, represents a straight chain organic group having an even number of carbon chain lengths. X represents a choline residue, an ethanolamine residue, a serine residue, or an insitol residue. When X is a choline residue, it is phosphatidylcholine, when it is an ethanolamine residue, it is phosphatidylethanolamine, when it is a serine residue, it is phosphatidylserine, and when it is inositol, it is phosphatidylserine. It becomes sol-inositol.

d) Below - Fusu 7 atidic acid represented by a pattern hole [畢] (XIV) CH20COR.

Here, R1 and R2 are chain organic groups, and at least one of them is preferably a straight chain organic group having an even number of carbon chain lengths.

W) Below - Sphingolipid (
XV) HNH -O where R is a linear organic group with an even carbon chain length,
represents a sugar residue, a phosphate residue, or an amine base residue such as a purine or ethanolamine.

The amount of the fatty acid or derivative thereof having an odd carbon chain length in the hair nourishing cosmetic composition of the present invention is 0.1 to 15.0% by weight, preferably 0.5 to 5% by weight. If the amount is less than 0.1% by weight, the hair-nourishing effect will decrease, and if it exceeds 15.0% by weight, storage stability at low temperatures will decrease, which is not preferable.

The cationic surfactants used in the hair nourishing cosmetic composition of the present invention are shown below.

b) Compound shown below - Monka (X■) (However, R1
represents an alkyl group having 8 to 22 carbon atoms or a hydroquinalkyl group, and R2 and R3 each represent an alkyl group having 1 to 3 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, or a benyl group.

RA represents either the same substituent as R4 or R2.

X represents a halodane atom or a monoalkaline sulfate group having an alkyl group having 1 to 3 carbon atoms. ) Mouth) Below - Monana [expletive]
A compound represented by (Represents a ron atom, methyl sulfate group, or ethyl sulfate group.) C) Compounds represented by the following - Monana [''...['A/[l (However, R8 has 10 to 22 carbon atoms. R7 represents an alkyl group having 2 to 22 carbon atoms.) Specific examples of compounds represented by the above formula include cetyltrimethylammonium chloride, cetostearyltrimethylammonium chloride, stearyltrimethylammonium chloride, eiko Examples include siltrimethylammonium chloride, behenyltrimethylammonium chloride, eicosyldimethylammonium chloride, stearylbenzylammonium chloride, and behenyltrimethylbennolammonium chloride.

In addition, specific examples of the compound represented by the above formula [expletive] include zostearylliethenoxymethylammonium halide, zo/yalumitylpolyethenoxyethylammonium halide, dino9lumitylpolyethenoxyhydroxyethylammonium halide, Examples include stearylpolyethenoxyammonium halide, distearylpolyethenoxyethylammonium ethyl sulfate, and the like.

Furthermore, specific examples of the compound represented by the above formula [expletive] Toshite, Nα-cocoyl-L-arginine ethyl ester-D
L-1: 'Lori Donkar? N[i[, Nα-cocoyl-
L-arginine methyl ester-DL-pyrrolidonecar? Nα-myristoyl-L-arginine ethyl ester-DL-hyloridonecalgen [i, Nα-/
4-lumitoyl-1-arginine ethyl ester-DL-
ni' lolidone cargonate, Nα-stearoyl L-
Examples include alinine ethyl ester-DL-pyrrolidone caldate.

The blending amount of the cationic surfactant in the hair nourishing cosmetic of the present invention is 0.01 to 5.0%, preferably 0.01 to 5.0%.
It is 1 to 1.2% by weight. The blending amount is 0.01it'i%
If left undropped, the storage stability at low temperatures will decrease, and 7'c5.
Exceeding O[[ is also undesirable since storage stability at low temperatures decreases.

Examples of branched ester oils that are liquid at room temperature and used in the hair-growth cosmetics of the present invention include inglovir myristate, inflovir palmitate, inglovir caproate, inthropil caprylate, inglovir cabrate, and lauric acid. Examples include isopropyl, inglovir stearate, inglovil petroselate, isoamyl petroselate, isoglobil oleate, isobutyl oleate, isoamyl oleate, ingtyl elaidate, inbutyl ricinoleate, intridecyl myristate, octyl doderel myristate, etc. Ra's 1fl! Or two or more types can be used.

The formulation of ester oil in the hair nourishing cosmetic of the present invention is as follows:
The content is 1 to 30% by weight, preferably 5 to 20% by weight. If the blending amount is less than 1% by weight, the storage stability at low temperatures will decrease, and if it exceeds 30% by weight, the storage stability at low temperatures will similarly decrease, which is not preferable.

In the hair nourishing cosmetic composition of the present invention, a nonionic surfactant having a glycerin skeleton, for example, diethylene hydrogenated castor oil, diethylene hydrogenated castor oil in polio, polio, xyethylene glyceryl monostearate, Decaglyceryl monostearate, hexiteglyceryl monooleate, polyoxyethylene sorbittetraoleate, 4-lyoxyethylene glyceryl triisostearate, polyΦ diethylene glyceryl trioleate, polyoxyethylene hydrogenated castor oil monolaurate, phorioxy It is preferable to blend one or more types of ethylene hydrogenated castor oil monoinstearate and the like.

The blending amount of the nonionic surfactant in the hair nourishing cosmetic composition of the present invention is preferably 0.1 to 15.0% by weight, more preferably 0.3 to 5% by weight.

The hair nourishing cosmetic of the present invention further includes, as an auxiliary ingredient,
Various commonly used substances such as esters, polyhydric alcohols, surfactants, oils and fats, etc. can be blended. In addition, known hair nourishing agents such as vitamins, hormones, amino acids, vasodilators, anti-inflammatory agents, cell activators, keratolytic agents, bactericidal agents, and transdermal absorption enhancers may also be incorporated as medicinal ingredients.

[Effect] The hair nourishing cosmetic composition of the present invention has an excellent hair nourishing effect and is significantly improved in low temperature stability.

[Example] Examples and comparative examples of the present invention will be shown below to specifically explain the effects of the present invention. Before explaining each side, the hair growth effect test method and low-temperature stability evaluation method adopted by each side will be explained.

(Hair nourishing effect test method) Body f [approx. 2.5. A group of 6 to 8 F New Zealand White rabbits was prepared, the hair on the back was removed, and only those in the resting phase were used for the experiment. 0.2 rats each of the test sample was applied to the hair-removed backs of animals in the telogen phase, twice a week for 30~
The product was sprayed for 60 days, and the number of days required for telogen hair to convert into anagen hair was determined. The "days of promotion" used as an index of hair growth effect indicates how many days the conversion from telogen hair to anagen hair is promoted compared to spraying ethanol that does not contain the test substance. It is something. The hair growth effect was evaluated based on the criteria shown in Table 1 below.

(Low-temperature stability evaluation method) Approximately 50 g of the test sample is placed in a transparent glass bottle, stored in a high-temperature tank at -5°C for one month, and then returned to room temperature to observe and judge the emulsification state.

○...No change △...Slight change ×...Changes such as aggregation or separation 28 types of test samples shown in Tables 2 to 5 below were prepared, and the Characteristics were evaluated.

The results are shown in the same table.

From Tables 2 to 5, it can be seen that the test samples (Examples 1 to 23) containing active ingredients within the scope of the present invention all showed excellent properties, while those containing active ingredients outside the scope of the present invention It can be seen that none of the test samples containing the components (Comparative Examples 1 to 5) exhibited superior NFC characteristics.

Next, examples of formulations in which the hair nourishing cosmetic composition of the present invention is applied to various actual products will be shown. It has been confirmed that all examples exhibit excellent properties.

Formulation example 1 (hair growth agent) Monium chloride I POE (20) Hydrogenated castor oil 1acetic acid dt-
α-Tocopherol 0.2 Inglovir palmitate 7.0 Bantothenyl ethyl ether 0.3 Ethinyl estradiol 0.
0004 Safflower oil 0.3 Biotin 0.02 Aspergillus extract (
-St 0.1 hinokitiol
0.05 Succinic acid 0.
No. 5 fee 0.599
．． 5% ethanol 5. ONI water
Remaining formulation example 2 (hair tonic) Nicum chloride 0.5 Glyceryl monostearate 0.5 Isopropyl myristate 7.0 Inglovil methylphenol 0.05 t-menthol
02 Benzyl Nicotinate 0.
003 fragrance 0
．． 595% ethanol 5.0 Purified water
Remaining formulation example 3 (Hairy Nakatsudo) Cetostearylmethylammonium chloride 0.5POE (20
) Hydrogenated castor oil 0.5 no glumitate inoglovir 7.0702 ECW
0.14 Liogishiguropyrenebutyl ether 15.0 Fragrance
0.5961% ethanol 5.0 Purified water
Remaining formulation example 4 (aerosol hair growth agent) [0 liquid] Ingredients Weight% Ammonium chloride 0.5 POE (15
) Glyceryl monostearate 0.5 Inglovir myristate 7.0 Citric acid
0.3t-menthol
0.1biochiy 0
．． 02 Fragrance 0.5 Ethanol 5.0 Purified water
Remainder (diluent for filling) Stock solution 35 Freon 114 45

Claims (1)

[Claims] (1) 0.1 to 15% by weight of one or more fatty acids or derivatives thereof having an odd carbon chain length, and 0.01 to 5% by weight of one or more cationic surfactants.
and 1 to 30% by weight of one or more ester oils having branched chain lengths that are liquid at room temperature.