JP2596446B2 - Ｚ―１―（ｐ―β―ジメチルアミノエトキシフェニル）―１―（ｐ―ヒドロキシフェニル）―２―フェニル―ブド―１―エンの安定な溶媒付加物、その製造法及びそれを含有する薬剤 - Google Patents

Ｚ―１―（ｐ―β―ジメチルアミノエトキシフェニル）―１―（ｐ―ヒドロキシフェニル）―２―フェニル―ブド―１―エンの安定な溶媒付加物、その製造法及びそれを含有する薬剤

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Publication number
JP2596446B2
JP2596446B2 JP63093309A JP9330988A JP2596446B2 JP 2596446 B2 JP2596446 B2 JP 2596446B2 JP 63093309 A JP63093309 A JP 63093309A JP 9330988 A JP9330988 A JP 9330988A JP 2596446 B2 JP2596446 B2 JP 2596446B2
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JP
Japan
Prior art keywords
formula
compound
general formula
carbon atoms
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP63093309A
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English (en)
Japanese (ja)
Other versions
JPS6445347A (en
Inventor
インゴマール・グラーフェ
ヘルムート・シッカネーダー
ペーター・ダブリュー・ユングブルット
クルト・ヘンニング・アーレンス
Original Assignee
ホイマン・ファーマ・ジー・エム・ビー・エイチ・アンド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ホイマン・ファーマ・ジー・エム・ビー・エイチ・アンド・カンパニー filed Critical ホイマン・ファーマ・ジー・エム・ビー・エイチ・アンド・カンパニー
Publication of JPS6445347A publication Critical patent/JPS6445347A/ja
Application granted granted Critical
Publication of JP2596446B2 publication Critical patent/JP2596446B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63093309A 1987-04-21 1988-04-15 Ｚ―１―（ｐ―β―ジメチルアミノエトキシフェニル）―１―（ｐ―ヒドロキシフェニル）―２―フェニル―ブド―１―エンの安定な溶媒付加物、その製造法及びそれを含有する薬剤 Expired - Fee Related JP2596446B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87105803A EP0287690B1 (de) 1987-04-21 1987-04-21 Stabile Lösungsmitteladdukte von Z-1-(p-beta-Dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-en
EP87105803.8 1987-04-21

Publications (2)

Publication Number Publication Date
JPS6445347A JPS6445347A (en) 1989-02-17
JP2596446B2 true JP2596446B2 (ja) 1997-04-02

Family

ID=8196934

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63093309A Expired - Fee Related JP2596446B2 (ja) 1987-04-21 1988-04-15 Ｚ―１―（ｐ―β―ジメチルアミノエトキシフェニル）―１―（ｐ―ヒドロキシフェニル）―２―フェニル―ブド―１―エンの安定な溶媒付加物、その製造法及びそれを含有する薬剤

Country Status (18)

Country Link
US (1) US4973755A (https=)
EP (1) EP0287690B1 (https=)
JP (1) JP2596446B2 (https=)
KR (1) KR940010274B1 (https=)
AR (1) AR243494A1 (https=)
AT (1) ATE80152T1 (https=)
AU (1) AU607198B2 (https=)
CA (1) CA1305972C (https=)
DE (1) DE3781546D1 (https=)
DK (1) DK171748B1 (https=)
ES (1) ES2044860T3 (https=)
GR (1) GR3005582T3 (https=)
HU (1) HU204501B (https=)
IE (1) IE62488B1 (https=)
IL (1) IL85804A (https=)
NZ (1) NZ224296A (https=)
PT (1) PT87268B (https=)
ZA (1) ZA882016B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5847007A (en) * 1993-05-13 1998-12-08 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US5770609A (en) * 1993-01-28 1998-06-23 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1995011879A1 (en) * 1993-10-25 1995-05-04 Taiho Pharmaceutical Co., Ltd. Process for producing acid-addition salt of z-isomer of triphenylethylene compound
DE4407742C1 (de) * 1994-03-08 1995-06-22 Hexal Pharma Gmbh Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat
US5650425A (en) * 1994-04-04 1997-07-22 Pharmos Corporation Permanently ionic derivatives of steroid hormones and their antagonists
CA2223595C (en) 1995-06-07 2008-08-05 Neorx Corporation Prevention and treatment of cardiovascular pathologies with tamoxifen analogues
AU725286B2 (en) 1996-01-20 2000-10-12 Bradford University Tamoxifen and analogues thereof
GB9601167D0 (en) * 1996-01-20 1996-03-20 Univ Bradford Tamoxifen and analogues thereof
US6083990A (en) 1997-04-02 2000-07-04 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof
EP1043986B1 (en) * 1997-12-23 2003-04-16 Hexal Ag Mixture and pharmaceutical composition comprising z-4-hydroxytamoxifen and cyclodextrin
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
WO2004054557A2 (en) * 2002-12-18 2004-07-01 Laboratoires Besins International Treatment of mastalgia with 4-hydroxy tamoxifen
JP4684655B2 (ja) * 2002-12-18 2011-05-18 ラボラトワール ブザン アンテルナスィヨナル ４−ヒドロキシタモキシフェンによる乳房密度低下
CA2519980C (en) * 2003-04-01 2012-04-10 Laboratoires Besins International Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
US7767717B2 (en) * 2003-06-09 2010-08-03 Ascend Therapeutics, Inc. Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
CA2529852A1 (en) * 2003-06-20 2004-12-29 Viral Genomix, Inc. Compositions for and methods for treating hiv
US7968532B2 (en) * 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
US7507769B2 (en) * 2004-03-22 2009-03-24 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen
CN1946387B (zh) * 2004-03-22 2011-08-31 法国法杏大药厂 4-羟基三苯氧胺在制备治疗和预防良性乳房疾病的药物中的应用
EP1579856A1 (en) * 2004-03-22 2005-09-28 Laboratoires Besins International Treatment and prevention of benign breast disease with 4-hydroxy tamoxifen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE637389A (https=) * 1962-09-13
GB1099093A (en) * 1965-09-03 1968-01-17 Ici Ltd Alkene derivatives
GB1560274A (en) * 1977-02-28 1980-02-06 Ici Ltd Phenylbut 1-ene derivatives having antiostrogenicactivity
DE2860900D1 (en) * 1977-08-22 1981-11-05 Ici Plc Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
DE3046719C2 (de) * 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
DE3239610A1 (de) * 1982-10-26 1984-04-26 Klinge Pharma GmbH, 8000 München Neue 1,1,2-triphenyl-but-l-en-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
IL85804A0 (en) 1988-09-30
PT87268B (pt) 1992-08-31
AR243494A1 (es) 1993-08-31
ZA882016B (en) 1988-12-28
HUT50318A (en) 1990-01-29
US4973755A (en) 1990-11-27
DE3781546D1 (de) 1992-10-08
DK171748B1 (da) 1997-05-05
IE62488B1 (en) 1995-02-08
ES2044860T3 (es) 1994-01-16
EP0287690B1 (de) 1992-09-02
CA1305972C (en) 1992-08-04
DK189888D0 (da) 1988-04-07
NZ224296A (en) 1990-02-26
GR3005582T3 (https=) 1993-06-07
IL85804A (en) 1991-07-18
KR940010274B1 (ko) 1994-10-22
HU204501B (en) 1992-01-28
DK189888A (da) 1988-10-22
EP0287690A1 (de) 1988-10-26
JPS6445347A (en) 1989-02-17
ATE80152T1 (de) 1992-09-15
KR880012528A (ko) 1988-11-28
AU1379888A (en) 1988-10-20
PT87268A (pt) 1988-05-01
AU607198B2 (en) 1991-02-28

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