JP2509046B2 - 胆汁酸およびその塩を含有する経口投与用の放出制御型胃液耐性製剤 - Google Patents

胆汁酸およびその塩を含有する経口投与用の放出制御型胃液耐性製剤

Info

Publication number
JP2509046B2
JP2509046B2 JP4091131A JP9113192A JP2509046B2 JP 2509046 B2 JP2509046 B2 JP 2509046B2 JP 4091131 A JP4091131 A JP 4091131A JP 9113192 A JP9113192 A JP 9113192A JP 2509046 B2 JP2509046 B2 JP 2509046B2
Authority
JP
Japan
Prior art keywords
acid
gastric juice
formulation
bile
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP4091131A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0597677A (ja
Inventor
マルキ エジジオ
タマニョーネ ジャンフランコ
ガブリエーレ ロチーニ レオーネ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARUFUA WATSUSERUMAN SpA
Original Assignee
ARUFUA WATSUSERUMAN SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARUFUA WATSUSERUMAN SpA filed Critical ARUFUA WATSUSERUMAN SpA
Publication of JPH0597677A publication Critical patent/JPH0597677A/ja
Application granted granted Critical
Publication of JP2509046B2 publication Critical patent/JP2509046B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP4091131A 1991-04-12 1992-04-10 胆汁酸およびその塩を含有する経口投与用の放出制御型胃液耐性製剤 Expired - Fee Related JP2509046B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT91A000114 1991-04-12
ITBO910114A IT1245891B (it) 1991-04-12 1991-04-12 Formulazioni farmaceutiche a rilascio controllato per uso orale gastroresistenti contenenti acidi biliari e loro sali.

Publications (2)

Publication Number Publication Date
JPH0597677A JPH0597677A (ja) 1993-04-20
JP2509046B2 true JP2509046B2 (ja) 1996-06-19

Family

ID=11337392

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4091131A Expired - Fee Related JP2509046B2 (ja) 1991-04-12 1992-04-10 胆汁酸およびその塩を含有する経口投与用の放出制御型胃液耐性製剤

Country Status (9)

Country Link
US (1) US5300300A (en:Method)
EP (1) EP0508312B1 (en:Method)
JP (1) JP2509046B2 (en:Method)
KR (1) KR970005177B1 (en:Method)
CA (1) CA2065652C (en:Method)
DE (1) DE69213800T2 (en:Method)
ES (1) ES2091970T3 (en:Method)
IT (1) IT1245891B (en:Method)
TW (1) TW215899B (en:Method)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions
IT1255968B (it) * 1992-11-27 1995-11-17 Composizioni farmaceutiche contenenti acido ursodesossicolico
IL109460A (en) * 1993-05-10 1998-03-10 Euro Celtique Sa Controlled release formulation comprising tramadol
KR100354702B1 (ko) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE29717252U1 (de) * 1997-09-26 1998-02-19 Dr. Falk Pharma GmbH, 79108 Freiburg Arzneimittelkit aus einem Budesonid-haltigen und einem Ursodesoxycholsäure-haltigen Arzneimittel zur Behandlung von cholestatischen Lebererkrankungen
JP4790123B2 (ja) 1998-07-24 2011-10-12 ヨー、セオ、ホン 胆汁酸を有する透明水溶液型製剤の調剤
US7772220B2 (en) * 2004-10-15 2010-08-10 Seo Hong Yoo Methods and compositions for reducing toxicity of a pharmaceutical compound
US20050158408A1 (en) * 1998-07-24 2005-07-21 Yoo Seo H. Dried forms of aqueous solubilized bile acid dosage formulation: preparation and uses thereof
US7303768B2 (en) * 1998-07-24 2007-12-04 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
BR0108080A (pt) * 2000-02-04 2006-02-07 Seo Hong Yoo Preparação de formas de dosagem de solução clara aquosa com ácidos biliares
US6821931B2 (en) * 2002-03-05 2004-11-23 Alpine Mud Products Corporation Water-based drilling fluid additive containing talc and carrier
US20040241252A1 (en) * 2003-05-29 2004-12-02 Abney Christopher Charles Pharmaceutical compositions for oral administration comprising lithium carbonate, processes of making the same, and methods of administering the same
US7145125B2 (en) * 2003-06-23 2006-12-05 Advanced Optical Technologies, Llc Integrating chamber cone light using LED sources
WO2005032549A1 (en) * 2003-09-26 2005-04-14 Smithkline Beecham Corporation Compositions and methods for treatment of fibrosis
US20050181047A1 (en) * 2004-02-18 2005-08-18 Jaime Romero Compositions and methods for timed release of water-soluble nutritional supplements
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
EP1789057B1 (en) * 2004-08-30 2010-02-24 Seo Hong Yoo Neuroprotective effect of solubilized udca in focal ischemic model
EP1809330B1 (en) * 2004-10-15 2011-04-27 Seo Hong Yoo Compositions for reducing toxicity of cisplatin, carboplatin, and oxaliplatin
US20060142241A1 (en) * 2004-11-01 2006-06-29 Yoo Seo H Methods and compositions for reducing neurodegeneration in amyotrophic lateral sclerosis
US20060275364A1 (en) * 2005-05-26 2006-12-07 Ahmed Salah U Flexible Solid Dosage Forms and Methods of Making and Using the Same
LT2124884T (lt) 2006-12-22 2019-08-26 Ironwood Pharmaceuticals, Inc. Tulžies rūgščių sekvestrantus apimančios kompozicijos, skirtos stemplės sutrikimų gydymui
KR101636958B1 (ko) * 2009-09-11 2016-07-06 주식회사 대웅제약 우루소데옥시콜린산-합성하이드로탈사이트-유드라짓 혼성체, 이를 함유하는 약학 조성물 및 그 제조방법
WO2013054285A1 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited A gastroretentive dosage system and process of preparation thereof
US20170119680A1 (en) 2015-10-30 2017-05-04 R.P. Scherer Technologies, Llc Extended release film-coated capsules
EP4013401A4 (en) 2019-08-12 2023-07-12 Massachusetts Institute of Technology Articles and methods for administration of therapeutic agents
CN118217294B (zh) * 2023-08-08 2024-11-29 成都赛璟生物医药科技有限公司 一种熊去氧胆酸复合物及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2340060A1 (de) * 1973-08-08 1975-02-20 Scherer Gmbh R P Magensaftresistente gelatinekapseln und verfahren zu deren herstellung
IT1101649B (it) 1978-12-15 1985-10-07 Lehner Ag Composizione farmaceutica ad azione prolungata contenente acidi biliari
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
IT1212141B (it) 1987-06-03 1989-11-08 So Ri Far S R L Composizioni farmaceutiche per la prevenzione e terapia della calcolosi delle vie biliari e della dispepsia biliare.

Also Published As

Publication number Publication date
TW215899B (en:Method) 1993-11-11
JPH0597677A (ja) 1993-04-20
ES2091970T3 (es) 1996-11-16
KR970005177B1 (ko) 1997-04-14
ITBO910114A0 (it) 1991-04-12
CA2065652A1 (en) 1992-10-13
IT1245891B (it) 1994-10-25
US5300300A (en) 1994-04-05
DE69213800T2 (de) 1997-02-20
EP0508312B1 (en) 1996-09-18
CA2065652C (en) 1999-01-12
DE69213800D1 (de) 1996-10-24
EP0508312A1 (en) 1992-10-14
KR920019360A (ko) 1992-11-19
ITBO910114A1 (it) 1992-10-12

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