JP2025510700A5 - - Google Patents
Info
- Publication number
- JP2025510700A5 JP2025510700A5 JP2024556005A JP2024556005A JP2025510700A5 JP 2025510700 A5 JP2025510700 A5 JP 2025510700A5 JP 2024556005 A JP2024556005 A JP 2024556005A JP 2024556005 A JP2024556005 A JP 2024556005A JP 2025510700 A5 JP2025510700 A5 JP 2025510700A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibody conjugate
- linker
- hetero
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22163943.8 | 2022-03-23 | ||
| EP22163943 | 2022-03-23 | ||
| PCT/EP2023/057561 WO2023180485A1 (en) | 2022-03-23 | 2023-03-23 | Antibody-conjugates for targeting of tumours expressing trop-2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025510700A JP2025510700A (ja) | 2025-04-15 |
| JP2025510700A5 true JP2025510700A5 (enExample) | 2026-03-31 |
Family
ID=81308125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024556005A Pending JP2025510700A (ja) | 2022-03-23 | 2023-03-23 | Ｔｒｏｐ－２を発現する腫瘍を標的化するための抗体コンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250090679A1 (enExample) |
| EP (1) | EP4496594A1 (enExample) |
| JP (1) | JP2025510700A (enExample) |
| KR (1) | KR20250024743A (enExample) |
| CN (1) | CN119212731A (enExample) |
| AU (1) | AU2023241225A1 (enExample) |
| CA (1) | CA3253220A1 (enExample) |
| IL (1) | IL315207A (enExample) |
| MX (1) | MX2024011520A (enExample) |
| WO (1) | WO2023180485A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020094670A1 (en) | 2018-11-05 | 2020-05-14 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
| IL315366A (en) | 2022-03-23 | 2024-11-01 | Synaffix Bv | Antibody pairs for targeting PTK7-expressing tumors |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| ATE265532T1 (de) | 1995-10-19 | 2004-05-15 | Bristol Myers Squibb Co | Monoklonaler antikörper br110 und dessen anwendung |
| CA2478047C (en) | 2002-03-01 | 2014-01-21 | Immunomedics, Inc. | Rs7 antibodies |
| US9745380B2 (en) | 2002-03-01 | 2017-08-29 | Immunomedics, Inc. | RS7 antibodies |
| WO2008029281A2 (en) | 2006-02-10 | 2008-03-13 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| US20080131428A1 (en) | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| US7420041B2 (en) | 2006-02-24 | 2008-09-02 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| CA2750038C (en) | 2009-02-05 | 2016-10-04 | Oncoxx S.R.L. | Anti-trop-2 monoclonal antibodies and uses thereof in the treatment and diagnosis of tumors |
| JPWO2011155579A1 (ja) | 2010-06-10 | 2013-08-15 | 北海道公立大学法人 札幌医科大学 | 抗Ｔｒｏｐ−２抗体 |
| US8871908B2 (en) | 2011-11-11 | 2014-10-28 | Rinat Neuroscience Corp. | Antibodies specific for Trop-2 and their uses |
| US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
| ES2659270T5 (en) | 2012-10-23 | 2026-02-11 | Synaffix Bv | Modified antibody, antibody-conjugate and process for the preparation thereof |
| US9107960B2 (en) | 2012-12-13 | 2015-08-18 | Immunimedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| PT3088419T (pt) | 2013-12-25 | 2019-01-11 | Daiichi Sankyo Co Ltd | Conjugado de anticorpo anti-trop2-fármaco |
| KR20170030648A (ko) | 2014-08-04 | 2017-03-17 | 시나픽스 비.브이. | 베타-(1,4)-n-아세틸갈락토오스아미닐트랜스퍼라아제, 또는 이의 돌연변이체를 이용한 당 단백질의 변형 방법 |
| ES2740907T3 (es) | 2014-10-03 | 2020-02-07 | Synaffix Bv | Enlazador de sulfamida, conjugados de los mismos y métodos de preparación |
| HUE038511T2 (hu) | 2015-04-23 | 2018-10-29 | Synaffix Bv | (1,4)-N-acetil-galaktóz-aminil-transzferáz vagy (1,4)-N-acetil-galaktóz-aminil-transzferázból származó glikoziltranszferázt alkalmazó, glikoprotein módosítására szolgáló eljárás |
| WO2017214491A1 (en) | 2016-06-09 | 2017-12-14 | Blinkbio, Inc. | Silanol based therapeutic payloads |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| WO2020094670A1 (en) * | 2018-11-05 | 2020-05-14 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
| CR20210541A (es) | 2019-03-29 | 2021-12-20 | Medimmune Ltd | Compuestos y conjugados de estos |
| HUE065484T2 (hu) | 2019-04-26 | 2024-05-28 | Immunogen Inc | Camptothecin-származékok |
| CN116209679A (zh) | 2020-06-05 | 2023-06-02 | 财团法人生物技术开发中心 | 含有抗间皮素抗体的抗体-药物共轭物及其用途 |
| NL2026947B1 (en) | 2020-11-20 | 2022-07-01 | Synaffix Bv | Tyrosine-based antibody conjugates |
| CN113816969B (zh) | 2021-04-30 | 2024-01-16 | 联宁（苏州）生物制药有限公司 | 依喜替康类化合物、其抗体药物偶联物及其应用 |
| JP7451677B2 (ja) | 2021-07-19 | 2024-03-18 | 煙台邁百瑞国際生物医薬股▲ふん▼有限公司 | 二成分毒素を担った抗体薬物複合体及びその応用 |
-
2023
- 2023-03-23 CN CN202380028866.0A patent/CN119212731A/zh active Pending
- 2023-03-23 AU AU2023241225A patent/AU2023241225A1/en active Pending
- 2023-03-23 JP JP2024556005A patent/JP2025510700A/ja active Pending
- 2023-03-23 EP EP23714682.4A patent/EP4496594A1/en active Pending
- 2023-03-23 IL IL315207A patent/IL315207A/en unknown
- 2023-03-23 KR KR1020247034725A patent/KR20250024743A/ko active Pending
- 2023-03-23 WO PCT/EP2023/057561 patent/WO2023180485A1/en not_active Ceased
- 2023-03-23 CA CA3253220A patent/CA3253220A1/en active Pending
-
2024
- 2024-09-19 MX MX2024011520A patent/MX2024011520A/es unknown
- 2024-09-20 US US18/892,270 patent/US20250090679A1/en active Pending
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