JP2025510623A5 - - Google Patents
Info
- Publication number
- JP2025510623A5 JP2025510623A5 JP2024554796A JP2024554796A JP2025510623A5 JP 2025510623 A5 JP2025510623 A5 JP 2025510623A5 JP 2024554796 A JP2024554796 A JP 2024554796A JP 2024554796 A JP2024554796 A JP 2024554796A JP 2025510623 A5 JP2025510623 A5 JP 2025510623A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody conjugate
- conjugate according
- pharmaceutically acceptable
- antibody
- fuc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22163924 | 2022-03-23 | ||
| EP22163924.8 | 2022-03-23 | ||
| PCT/EP2023/057560 WO2023180484A1 (en) | 2022-03-23 | 2023-03-23 | Antibody-conjugates for targeting of tumours expressing ptk7 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025510623A JP2025510623A (ja) | 2025-04-15 |
| JP2025510623A5 true JP2025510623A5 (enExample) | 2026-03-31 |
Family
ID=81308370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024554796A Pending JP2025510623A (ja) | 2022-03-23 | 2023-03-23 | Ｐｔｋ７を発現する腫瘍を標的化するための抗体コンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12440573B2 (enExample) |
| EP (1) | EP4496592A1 (enExample) |
| JP (1) | JP2025510623A (enExample) |
| KR (1) | KR20250024742A (enExample) |
| CN (1) | CN120826241A (enExample) |
| AU (1) | AU2023237619A1 (enExample) |
| CA (1) | CA3254479A1 (enExample) |
| IL (1) | IL315366A (enExample) |
| MX (1) | MX2024011518A (enExample) |
| WO (1) | WO2023180484A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020094670A1 (en) | 2018-11-05 | 2020-05-14 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
| JP2025533758A (ja) * | 2022-10-14 | 2025-10-09 | スーチュアン・コールン－バイオテック・バイオファーマシューティカル・カンパニー・リミテッド | 抗体－薬物複合体並びにその調製方法及び使用 |
| WO2025005240A1 (ja) * | 2023-06-30 | 2025-01-02 | 第一三共株式会社 | 活性炭材料を使用する精製工程を含む抗体－薬物コンジュゲートの製造方法 |
| EP4566631A1 (en) * | 2023-12-06 | 2025-06-11 | Heidelberg Pharma Research GmbH | New antibody drug conjugate as well as methods of production and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939255A (en) | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
| AU2006321841C1 (en) | 2005-12-08 | 2013-01-24 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use |
| WO2008029281A2 (en) | 2006-02-10 | 2008-03-13 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| AR069903A1 (es) * | 2007-11-30 | 2010-03-03 | Medarex Inc | Conjugado anticuerpo- molecula asociada dirigidos a la proteina tirosina quinasa 7 (ptk 7), composicion farmaceutica que lo comprende, acido nucleico, factor de expresion y celula huesped relacionados y su uso para preparar un medicamento util para el tratamiento o prevencion de cancer |
| US20090162359A1 (en) * | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| WO2009102820A2 (en) | 2008-02-11 | 2009-08-20 | Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services | Modified sugar substrates and methods of use |
| ES2659270T5 (en) | 2012-10-23 | 2026-02-11 | Synaffix Bv | Modified antibody, antibody-conjugate and process for the preparation thereof |
| PT3088419T (pt) | 2013-12-25 | 2019-01-11 | Daiichi Sankyo Co Ltd | Conjugado de anticorpo anti-trop2-fármaco |
| EP3137114B8 (en) | 2014-04-30 | 2021-08-04 | Pfizer Inc. | Anti-ptk7 antibody-drug conjugates |
| KR20170030648A (ko) | 2014-08-04 | 2017-03-17 | 시나픽스 비.브이. | 베타-(1,4)-n-아세틸갈락토오스아미닐트랜스퍼라아제, 또는 이의 돌연변이체를 이용한 당 단백질의 변형 방법 |
| ES2740907T3 (es) | 2014-10-03 | 2020-02-07 | Synaffix Bv | Enlazador de sulfamida, conjugados de los mismos y métodos de preparación |
| HUE038511T2 (hu) | 2015-04-23 | 2018-10-29 | Synaffix Bv | (1,4)-N-acetil-galaktóz-aminil-transzferáz vagy (1,4)-N-acetil-galaktóz-aminil-transzferázból származó glikoziltranszferázt alkalmazó, glikoprotein módosítására szolgáló eljárás |
| CN108883191B (zh) * | 2016-02-08 | 2022-10-14 | 西纳福克斯股份有限公司 | 用于靶向cd30肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法 |
| WO2017137457A1 (en) * | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| US11951175B2 (en) * | 2016-02-08 | 2024-04-09 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| WO2017214491A1 (en) | 2016-06-09 | 2017-12-14 | Blinkbio, Inc. | Silanol based therapeutic payloads |
| KR102294517B1 (ko) | 2016-12-29 | 2021-08-27 | 재단법인 생물기술개발중심 | 당단백질-약물 컨주게이트를 제조하는 방법 |
| EP3720504A1 (en) | 2017-12-06 | 2020-10-14 | Synaffix B.V. | Enediyne conjugates |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| WO2020094670A1 (en) | 2018-11-05 | 2020-05-14 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
| WO2020095248A1 (en) * | 2018-11-07 | 2020-05-14 | Crispr Therapeutics Ag | Anti-ptk7 immune cell cancer therapy |
| CR20210541A (es) | 2019-03-29 | 2021-12-20 | Medimmune Ltd | Compuestos y conjugados de estos |
| HUE065484T2 (hu) | 2019-04-26 | 2024-05-28 | Immunogen Inc | Camptothecin-származékok |
| CN116209679A (zh) | 2020-06-05 | 2023-06-02 | 财团法人生物技术开发中心 | 含有抗间皮素抗体的抗体-药物共轭物及其用途 |
| EP4213885A1 (en) | 2020-09-15 | 2023-07-26 | Synaffix B.V. | Antibody-exatecan conjugates |
| NL2026947B1 (en) | 2020-11-20 | 2022-07-01 | Synaffix Bv | Tyrosine-based antibody conjugates |
| CN113816969B (zh) | 2021-04-30 | 2024-01-16 | 联宁（苏州）生物制药有限公司 | 依喜替康类化合物、其抗体药物偶联物及其应用 |
| JP7451677B2 (ja) | 2021-07-19 | 2024-03-18 | 煙台邁百瑞国際生物医薬股▲ふん▼有限公司 | 二成分毒素を担った抗体薬物複合体及びその応用 |
| KR20250024741A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| CN119212731A (zh) | 2022-03-23 | 2024-12-27 | 新锐生物技术公司 | 用于靶向表达Trop-2的肿瘤的抗体缀合物 |
-
2023
- 2023-03-23 IL IL315366A patent/IL315366A/en unknown
- 2023-03-23 CA CA3254479A patent/CA3254479A1/en active Pending
- 2023-03-23 WO PCT/EP2023/057560 patent/WO2023180484A1/en not_active Ceased
- 2023-03-23 CN CN202380028783.1A patent/CN120826241A/zh active Pending
- 2023-03-23 AU AU2023237619A patent/AU2023237619A1/en active Pending
- 2023-03-23 KR KR1020247034724A patent/KR20250024742A/ko active Pending
- 2023-03-23 JP JP2024554796A patent/JP2025510623A/ja active Pending
- 2023-03-23 MX MX2024011518A patent/MX2024011518A/es unknown
- 2023-03-23 EP EP23713892.0A patent/EP4496592A1/en active Pending
-
2024
- 2024-09-20 US US18/892,253 patent/US12440573B2/en active Active
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