JP2025509552A5 - - Google Patents

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Publication number
JP2025509552A5
JP2025509552A5 JP2024554760A JP2024554760A JP2025509552A5 JP 2025509552 A5 JP2025509552 A5 JP 2025509552A5 JP 2024554760 A JP2024554760 A JP 2024554760A JP 2024554760 A JP2024554760 A JP 2024554760A JP 2025509552 A5 JP2025509552 A5 JP 2025509552A5
Authority
JP
Japan
Prior art keywords
aso
mesylphosphoamide
molecule
nucleotides
rna sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024554760A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025509552A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2023/015398 external-priority patent/WO2023177808A1/en
Publication of JP2025509552A publication Critical patent/JP2025509552A/ja
Publication of JP2025509552A5 publication Critical patent/JP2025509552A5/ja
Pending legal-status Critical Current

Links

JP2024554760A 2022-03-17 2023-03-16 修飾ギャップマーオリゴマー及びその使用方法 Pending JP2025509552A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263321019P 2022-03-17 2022-03-17
US63/321,019 2022-03-17
PCT/US2023/015398 WO2023177808A1 (en) 2022-03-17 2023-03-16 Modified gapmer oligomers and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2025509552A JP2025509552A (ja) 2025-04-11
JP2025509552A5 true JP2025509552A5 (https=) 2026-03-25

Family

ID=85985283

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024554760A Pending JP2025509552A (ja) 2022-03-17 2023-03-16 修飾ギャップマーオリゴマー及びその使用方法

Country Status (9)

Country Link
US (1) US20230383296A1 (https=)
EP (1) EP4493694A1 (https=)
JP (1) JP2025509552A (https=)
KR (1) KR20240158340A (https=)
CN (1) CN119032175A (https=)
AU (1) AU2023236560A1 (https=)
CA (1) CA3255691A1 (https=)
TW (1) TW202345861A (https=)
WO (1) WO2023177808A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118680948B (zh) * 2023-10-20 2025-08-22 思合基因(北京)生物科技有限公司 寡核苷酸及其在抗乙型肝炎病毒中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203862A1 (en) * 1998-03-26 2003-10-30 Miraglia Loren J. Antisense modulation of MDM2 expression
US20150247141A1 (en) * 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
KR101707437B1 (ko) * 2012-09-21 2017-02-16 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 구아니딘 가교를 갖는 인공 뉴클레오시드 및 올리고뉴클레오티드
GB201408623D0 (en) * 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
TW201718618A (zh) * 2015-09-18 2017-06-01 田邊三菱製藥股份有限公司 架橋型核酸GuNA,其製造方法,及中間體化合物
US20210052631A1 (en) * 2015-09-25 2021-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
PE20211783A1 (es) 2018-11-08 2021-09-08 Aligos Therapeutics Inc Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos
SG11202112741XA (en) * 2019-05-31 2021-12-30 Aligos Therapeutics Inc Modified gapmer oligonucleotides and methods of use
CA3189922A1 (en) * 2020-07-28 2022-02-03 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing app expression

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