|
DE69233046T2
(de)
|
1991-10-24 |
2004-03-04 |
Isis Pharmaceuticals, Inc., Carlsfeld |
Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
JP4236812B2
(ja)
|
1997-09-12 |
2009-03-11 |
エクシコン エ／エス |
オリゴヌクレオチド類似体
|
|
ES2234563T5
(es)
|
1999-02-12 |
2018-01-17 |
Daiichi Sankyo Company, Limited |
Nuevos análogos de nucleósidos y oligonucleótidos
|
|
US7053207B2
(en)
|
1999-05-04 |
2006-05-30 |
Exiqon A/S |
L-ribo-LNA analogues
|
|
US6617442B1
(en)
|
1999-09-30 |
2003-09-09 |
Isis Pharmaceuticals, Inc. |
Human Rnase H1 and oligonucleotide compositions thereof
|
|
WO2004035032A2
(en)
|
2002-08-20 |
2004-04-29 |
Neopharm, Inc. |
Pharmaceutical formulations of camptothecine derivatives
|
|
AU2003264441A1
(en)
|
2002-09-17 |
2004-04-08 |
The Circle For The Promotion Of Science And Engineering |
Method of screening remedy for proliferative disease
|
|
WO2004046160A2
(en)
|
2002-11-18 |
2004-06-03 |
Santaris Pharma A/S |
Amino-lna, thio-lna and alpha-l-oxy-ln
|
|
ATE443765T1
(de)
|
2003-03-21 |
2009-10-15 |
Santaris Pharma As |
Analoga kurzer interferierender rna (sirna)
|
|
EP2270162B1
(en)
|
2003-06-12 |
2018-10-03 |
Alnylam Pharmaceuticals Inc. |
Conserved hbv and hcv sequences useful for gene silencing
|
|
WO2006082053A1
(en)
|
2005-02-02 |
2006-08-10 |
Heidelberg Pharma Gmbh |
7-ethyl-10-hydroxy-camptothecin lipid ester derivatives
|
|
WO2007094818A2
(en)
|
2005-08-10 |
2007-08-23 |
Merck & Co., Inc. |
Novel hiv targets
|
|
WO2007031091A2
(en)
|
2005-09-15 |
2007-03-22 |
Santaris Pharma A/S |
Rna antagonist compounds for the modulation of p21 ras expression
|
|
WO2007090071A2
(en)
|
2006-01-27 |
2007-08-09 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
WO2007085485A2
(en)
|
2006-01-27 |
2007-08-02 |
Santaris Pharma A/S |
Lna modified phosphorothiolated oligonucleotides
|
|
WO2007107162A2
(en)
|
2006-03-23 |
2007-09-27 |
Santaris Pharma A/S |
Small internally segmented interfering rna
|
|
JP2009536222A
(ja)
|
2006-05-05 |
2009-10-08 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
Ｐｃｓｋ９の発現を調節するための化合物および方法
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
AU2007249349B2
(en)
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
DK2149605T3
(da)
|
2007-03-22 |
2013-09-30 |
Santaris Pharma As |
Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
|
|
CA2688321A1
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
|
US8379066B2
(en)
|
2007-06-27 |
2013-02-19 |
Christie Digital Systems Usa, Inc. |
Method and apparatus for scaling an image to produce a scaled image
|
|
AU2008272918B2
(en)
|
2007-07-05 |
2012-09-13 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
DK2356129T3
(da)
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
US20100249214A1
(en)
|
2009-02-11 |
2010-09-30 |
Dicerna Pharmaceuticals |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
KR101728655B1
(ko)
|
2008-12-18 |
2017-04-19 |
다이서나 파마수이티컬, 인크. |
유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
EP2580228B1
(en)
|
2010-06-08 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Substituted 2'-amino and 2'-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US9029341B2
(en)
|
2010-08-17 |
2015-05-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
|
|
LT3124610T
(lt)
|
2010-10-28 |
2019-08-12 |
Benitec Biopharma Limited |
Hbv gydymas
|
|
RU2013150331A
(ru)
|
2011-04-20 |
2015-05-27 |
Рош Гликарт Аг |
СПОСОБ И УСТРОЙСТВА ДЛЯ рН-ЗАВИСИМОГО ПРОХОЖДЕНИЯ ГЕМАТОЭНЦЕФАЛИЧЕСКОГО БАРЬЕРА
|
|
RS61447B1
(sr)
|
2011-04-21 |
2021-03-31 |
Glaxo Group Ltd |
Modulacija ekspresije virusa hepatitisa b (hbv)
|
|
EA024762B9
(ru)
|
2011-06-30 |
2017-04-28 |
Эрроухэд Рисерч Корпорейшн |
Композиции и способы ингибирования экспрессии генов вируса гепатита в
|
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
WO2013033230A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013159109A1
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Modulation of hepatitis b virus (hbv) expression
|
|
CN104837996A
(zh)
|
2012-11-15 |
2015-08-12 |
罗氏创新中心哥本哈根有限公司 |
抗apob反义缀合物化合物
|
|
DK2992098T3
(da)
|
2013-05-01 |
2019-06-17 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
|
|
HUE048738T2
(hu)
|
2013-06-27 |
2020-08-28 |
Roche Innovation Ct Copenhagen As |
Antiszensz oligomerek és konjugátumok, amelyek a PCK9-t célozzák meg
|
|
CA2935426C
(en)
|
2014-01-30 |
2023-07-25 |
F. Hoffmann-La Roche Ag |
Polyoligomer compound with biocleavable conjugates for reducing or inhibiting expression of a nucleic acid target
|
|
GB201408623D0
(en)
|
2014-05-15 |
2014-07-02 |
Santaris Pharma As |
Oligomers and oligomer conjugates
|
|
CN106795200B
(zh)
|
2014-10-10 |
2020-06-19 |
豪夫迈·罗氏有限公司 |
Galnac亚磷酰胺、其核酸缀合物及其用途
|
|
CN105777770B
(zh)
|
2014-12-26 |
2018-05-25 |
中国人民解放军第二军医大学 |
一种饱和长链脂肪酸修饰的7-乙基-10-羟基喜树碱化合物及其长循环脂质体
|
|
WO2016127002A1
(en)
|
2015-02-04 |
2016-08-11 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
|
CA2996722A1
(en)
|
2015-07-17 |
2017-01-26 |
Arcturus Therapeutics, Inc. |
Compositions and agents against hepatitis b virus and uses thereof
|
|
AU2016306275A1
(en)
|
2015-08-07 |
2018-02-08 |
Arrowhead Pharmaceuticals, Inc. |
RNAi therapy for Hepatitis B virus infection
|
|
WO2017178656A1
(en)
|
2016-04-14 |
2017-10-19 |
Roche Innovation Center Copenhagen A/S |
TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE
|
|
EP4219767A1
(en)
|
2016-06-17 |
2023-08-02 |
F. Hoffmann-La Roche AG |
Papd5 and papd7 inhibitors for treating a hepatitis b infection
|
|
US11504391B1
(en)
|
2016-11-23 |
2022-11-22 |
Alnylam Pharmaceuticals, Inc. |
Modified RNA agents with reduced off-target effect
|
|
SG11202009680XA
(en)
|
2018-04-05 |
2020-10-29 |
Hoffmann La Roche |
Use of fubp1 inhibitors for treating hepatitis b virus infection
|
|
CN112534055A
(zh)
|
2018-07-13 |
2021-03-19 |
豪夫迈·罗氏有限公司 |
用于调节rtel1表达的寡核苷酸
|
|
WO2021122869A1
(en)
*
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of scamp3 inhibitors for treating hepatitis b virus infection
|
|
WO2021122735A1
(en)
*
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of sept9 inhibitors for treating hepatitis b virus infection
|