JP2024531728A5 - - Google Patents
Info
- Publication number
- JP2024531728A5 JP2024531728A5 JP2024516476A JP2024516476A JP2024531728A5 JP 2024531728 A5 JP2024531728 A5 JP 2024531728A5 JP 2024516476 A JP2024516476 A JP 2024516476A JP 2024516476 A JP2024516476 A JP 2024516476A JP 2024531728 A5 JP2024531728 A5 JP 2024531728A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- nucleotide sequence
- seq
- double
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2113104.0 | 2021-09-14 | ||
| GBGB2113104.0A GB202113104D0 (en) | 2021-09-14 | 2021-09-14 | Antagonist of pcsk9 |
| GB2207239.1 | 2022-05-18 | ||
| GBGB2207239.1A GB202207239D0 (en) | 2022-05-18 | 2022-05-18 | Treatment of cardiovascular disease 2 |
| PCT/EP2022/075355 WO2023041508A2 (en) | 2021-09-14 | 2022-09-13 | Treatment of cardiovascular disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024531728A JP2024531728A (ja) | 2024-08-29 |
| JP2024531728A5 true JP2024531728A5 (https=) | 2025-07-23 |
Family
ID=83691543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024516476A Pending JP2024531728A (ja) | 2021-09-14 | 2022-09-13 | 心血管疾患の処置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250283076A1 (https=) |
| EP (1) | EP4402263A2 (https=) |
| JP (1) | JP2024531728A (https=) |
| CA (1) | CA3229020A1 (https=) |
| WO (1) | WO2023041508A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL312811A (en) | 2021-11-16 | 2024-07-01 | Shanghai Argo Biopharmaceutical Co Ltd | Composition and method for inhibiting angiotensinogen (agt) protein expression |
| TW202345865A (zh) * | 2022-01-24 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 抑制LPA(Apo(a))蛋白表達的組合物和方法 |
| WO2024189348A1 (en) * | 2023-03-14 | 2024-09-19 | Argonaute RNA Limited | Conjugate comprising a double stranded rna molecule linked to a single stranded dna molecule |
| WO2024228030A2 (en) * | 2023-05-04 | 2024-11-07 | Argonaute RNA Limited | Dual silencing |
| EP4722365A1 (en) * | 2023-05-26 | 2026-04-08 | Visirna Therapeutics (Suzhou) Co., Ltd. | Double-stranded nucleotide compound for metabolic diseases and use thereof |
| CN119464281A (zh) * | 2023-08-09 | 2025-02-18 | 北京福元医药股份有限公司 | 抑制DGAT2基因表达的siRNA、siRNA缀合物或其前药和药物组合物及用途 |
| WO2025040139A1 (zh) * | 2023-08-23 | 2025-02-27 | 云合智药（苏州）生物科技有限公司 | 用于抑制二酰甘油-O-酰基转移酶2表达的RNAi剂及其应用 |
| TW202540420A (zh) * | 2023-11-15 | 2025-10-16 | 大陸商北京加科瑞康醫藥科技有限公司 | 用於抑制LPA的基因表現的siRNA，含其的組合物及其用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02008616A (es) | 2000-03-03 | 2003-02-24 | Smithkline Beecham Biolog | Vacuna para el tratamiento de la arterosclerosis. |
| GB0121171D0 (en) | 2001-08-31 | 2001-10-24 | Glaxosmithkline Biolog Sa | Vaccine |
| GB0305794D0 (en) | 2003-03-13 | 2003-04-16 | Glaxosmithkline Biolog Sa | Vaccine |
| US7825235B2 (en) | 2003-08-18 | 2010-11-02 | Isis Pharmaceuticals, Inc. | Modulation of diacylglycerol acyltransferase 2 expression |
| WO2005044981A2 (en) | 2003-10-23 | 2005-05-19 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina) |
| EP1891216B1 (en) * | 2005-05-25 | 2012-02-22 | The University Of York | Hybrid interfering rna |
| JP2009536222A (ja) | 2006-05-05 | 2009-10-08 | アイシス ファーマシューティカルズ， インコーポレーテッド | Ｐｃｓｋ９の発現を調節するための化合物および方法 |
| CA2658183A1 (en) * | 2006-07-17 | 2008-01-24 | Sirna Therapeutics Inc. | Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina) |
| WO2010141511A2 (en) * | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| WO2012058693A2 (en) * | 2010-10-29 | 2012-05-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibition of pcsk9 genes |
| IL292159B1 (en) * | 2012-12-05 | 2026-04-01 | Alnylam Pharmaceuticals Inc | PCSK9 iRNA compositions and methods of using them |
| DK2992098T3 (da) | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3011026B1 (en) | 2013-06-21 | 2019-12-18 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile |
| JOP20160211B1 (ar) | 2015-10-01 | 2021-08-17 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| KR102502031B1 (ko) | 2016-11-16 | 2023-02-20 | 퍼듀 리서치 파운데이션 | 체중 및 대사 증후군을 조절하기 위한 조성물 및 방법 |
| HRP20230127T1 (hr) | 2017-11-13 | 2023-03-31 | Silence Therapeutics Gmbh | Nukleinske kiseline za inhibiranje ekspresije lpa u stanici |
| PH12021550801B1 (en) * | 2018-11-13 | 2024-04-26 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of lpa in a cell |
| WO2021001646A2 (en) * | 2019-07-02 | 2021-01-07 | Argonaute RNA Limited | Apolipoprotein b antagonist |
| MX2022007005A (es) * | 2019-12-09 | 2022-08-25 | Amgen Inc | Construcciones de iarn y metodos para inhibir la expresion de lpa. |
| CN115066498A (zh) * | 2020-03-16 | 2022-09-16 | 阿尔戈诺特Rna有限公司 | Pcsk9的拮抗剂 |
-
2022
- 2022-09-13 WO PCT/EP2022/075355 patent/WO2023041508A2/en not_active Ceased
- 2022-09-13 CA CA3229020A patent/CA3229020A1/en active Pending
- 2022-09-13 EP EP22789482.1A patent/EP4402263A2/en active Pending
- 2022-09-13 JP JP2024516476A patent/JP2024531728A/ja active Pending
- 2022-09-13 US US18/691,775 patent/US20250283076A1/en active Pending
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