KR20240158340A - 변형 갭머 올리고머 및 이의 사용 방법 - Google Patents

변형 갭머 올리고머 및 이의 사용 방법 Download PDF

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KR20240158340A
KR20240158340A KR1020247033852A KR20247033852A KR20240158340A KR 20240158340 A KR20240158340 A KR 20240158340A KR 1020247033852 A KR1020247033852 A KR 1020247033852A KR 20247033852 A KR20247033852 A KR 20247033852A KR 20240158340 A KR20240158340 A KR 20240158340A
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phosphoramidate
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레오니드 베이글맨
비벡 쿠마르 라즈완시
락스만 엘테푸
사울 마르티네즈 몬테로
진 홍
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알리고스 테라퓨틱스 인코포레이티드
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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KR1020247033852A 2022-03-17 2023-03-16 변형 갭머 올리고머 및 이의 사용 방법 Pending KR20240158340A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263321019P 2022-03-17 2022-03-17
US63/321,019 2022-03-17
PCT/US2023/015398 WO2023177808A1 (en) 2022-03-17 2023-03-16 Modified gapmer oligomers and methods of use thereof

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KR20240158340A true KR20240158340A (ko) 2024-11-04

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KR1020247033852A Pending KR20240158340A (ko) 2022-03-17 2023-03-16 변형 갭머 올리고머 및 이의 사용 방법

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US (1) US20230383296A1 (https=)
EP (1) EP4493694A1 (https=)
JP (1) JP2025509552A (https=)
KR (1) KR20240158340A (https=)
CN (1) CN119032175A (https=)
AU (1) AU2023236560A1 (https=)
CA (1) CA3255691A1 (https=)
TW (1) TW202345861A (https=)
WO (1) WO2023177808A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118680948B (zh) * 2023-10-20 2025-08-22 思合基因(北京)生物科技有限公司 寡核苷酸及其在抗乙型肝炎病毒中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203862A1 (en) * 1998-03-26 2003-10-30 Miraglia Loren J. Antisense modulation of MDM2 expression
US20150247141A1 (en) * 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
KR101707437B1 (ko) * 2012-09-21 2017-02-16 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 구아니딘 가교를 갖는 인공 뉴클레오시드 및 올리고뉴클레오티드
GB201408623D0 (en) * 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
TW201718618A (zh) * 2015-09-18 2017-06-01 田邊三菱製藥股份有限公司 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物
US20210052631A1 (en) * 2015-09-25 2021-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
PE20211783A1 (es) 2018-11-08 2021-09-08 Aligos Therapeutics Inc Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos
SG11202112741XA (en) * 2019-05-31 2021-12-30 Aligos Therapeutics Inc Modified gapmer oligonucleotides and methods of use
CA3189922A1 (en) * 2020-07-28 2022-02-03 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing app expression

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Publication number Publication date
US20230383296A1 (en) 2023-11-30
AU2023236560A1 (en) 2024-10-03
CA3255691A1 (en) 2023-09-21
JP2025509552A (ja) 2025-04-11
WO2023177808A1 (en) 2023-09-21
EP4493694A1 (en) 2025-01-22
CN119032175A (zh) 2024-11-26
TW202345861A (zh) 2023-12-01

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