|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
JP2528107B2
(ja)
|
1985-03-15 |
1996-08-28 |
サマ−トン,ジエ−ムス |
ポリヌクレオチド測定試薬と方法
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US4828971A
(en)
|
1988-03-24 |
1989-05-09 |
Eastman Kodak Company |
Thermally processable element comprising a backing layer
|
|
CA1251835A
(en)
|
1988-04-05 |
1989-03-28 |
Wai-Cheung Tang |
Dielectric image-resonator multiplexer
|
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
|
AU649074B2
(en)
|
1990-10-12 |
1994-05-12 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Modified ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5736557A
(en)
|
1994-06-17 |
1998-04-07 |
Hoffman-La Roche, Inc. |
N,N-bis (quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
WO1997026270A2
(en)
|
1996-01-16 |
1997-07-24 |
Ribozyme Pharmaceuticals, Inc. |
Synthesis of methoxy nucleosides and enzymatic nucleic acid molecules
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
DK1068241T3
(da)
|
1998-04-02 |
2008-02-04 |
Genentech Inc |
Antistofvarianter og fragmenter deraf
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
EP1071753A2
(en)
|
1998-04-20 |
2001-01-31 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
|
CA2328356A1
(en)
|
1999-12-22 |
2001-06-22 |
Itty Atcravi |
Recreational vehicles
|
|
DK1242438T3
(da)
|
1999-12-29 |
2007-02-12 |
Immunogen Inc |
Cytotoksiske midler omfattende modificerede doxorubiciner og daunorubiciner og deres terapeutiske anvendelse
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
EP1191097A1
(en)
*
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2002257333A1
(en)
*
|
2002-02-22 |
2003-09-09 |
Linda L. Bambrick |
Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms
|
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
|
PT1527176E
(pt)
|
2002-08-05 |
2007-04-30 |
Atugen Ag |
Novas formas de muléculas de arn de interferência
|
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
DK2284266T3
(da)
|
2002-11-14 |
2014-01-13 |
Thermo Fisher Scient Biosciences Inc |
sIRNA-MOLEKYLE MOD TP53
|
|
CA2796924C
(en)
*
|
2002-11-25 |
2016-12-13 |
Nonprofit Organization Translational Research Organization Of Duchenne Muscular Dystrophy |
Ena nucleic acid pharmaceuticals capable of modifying splicing of mrna precursors
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
AU2003225410A1
(en)
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
CN104998273A
(zh)
|
2003-11-06 |
2015-10-28 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
US7494925B2
(en)
|
2004-02-23 |
2009-02-24 |
Micron Technology, Inc. |
Method for making through-hole conductors for semiconductor substrates
|
|
EP1766010B1
(en)
|
2004-06-28 |
2011-02-16 |
The University Of Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
|
FR2874384B1
(fr)
*
|
2004-08-17 |
2010-07-30 |
Genethon |
Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
|
|
CA2586909A1
(en)
|
2004-11-12 |
2006-12-14 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
|
US7429482B2
(en)
|
2005-01-13 |
2008-09-30 |
United States Of America As Represented By The Department Of Veterans Affairs |
Screening tools for discovery of novel anabolic agents
|
|
CA2605512A1
(en)
*
|
2005-04-22 |
2006-10-26 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secondary rna structure.
|
|
US7736647B2
(en)
|
2005-06-15 |
2010-06-15 |
Monoclonal Antibodies Therapeutics |
Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
|
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
KR100699874B1
(ko)
|
2005-11-08 |
2007-03-28 |
삼성전자주식회사 |
삽입형 연결부를 갖는 비. 지. 에이 패키지 그 제조방법 및이를 포함하는 보드 구조
|
|
HUE035799T2
(en)
|
2006-05-10 |
2018-05-28 |
Sarepta Therapeutics Inc |
Cationic oligonucleotide analogues containing subunits
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
PT2049664E
(pt)
|
2006-08-11 |
2012-01-03 |
Prosensa Technologies Bv |
Oligonucleotídeos de cadeia simples complementares dos elementos repetitivos para tratar perturbações genéticas associadas à instabilidade das repetições do adn
|
|
US9063129B2
(en)
|
2007-06-15 |
2015-06-23 |
Idexx Laboratories, Inc. |
Device, kit and method for hookworm antigen capture and detection
|
|
WO2009005793A2
(en)
*
|
2007-06-29 |
2009-01-08 |
Avi Biopharma, Inc. |
Tissue specific peptide conjugates and methods
|
|
DK2185816T3
(en)
|
2007-08-29 |
2018-03-12 |
Mhi Vestas Offshore Wind As |
MONOPILE FOUNDATION FOR OFFSHORE WINDMILL
|
|
PL2203173T3
(pl)
|
2007-10-26 |
2016-06-30 |
Academisch Ziekenhuis Leiden |
Środki i sposoby przeciwdziałania zaburzeniom mięśni
|
|
WO2009099942A2
(en)
|
2008-01-31 |
2009-08-13 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides and uses thereof
|
|
US20110081362A1
(en)
|
2008-01-31 |
2011-04-07 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
EP2842575B1
(en)
|
2008-03-18 |
2017-09-27 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
EP3604533A1
(en)
|
2008-04-11 |
2020-02-05 |
Arbutus Biopharma Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
US8248352B2
(en)
|
2008-04-25 |
2012-08-21 |
Lg Display Co., Ltd. |
Driving circuit of liquid crystal display
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110130346A1
(en)
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
US8575305B2
(en)
|
2008-06-04 |
2013-11-05 |
Medical Research Council |
Cell penetrating peptides
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
AU2013204438B2
(en)
|
2008-10-24 |
2016-12-22 |
Sarepta Therapeutics, Inc. |
Multiple exon skipping compositions for DMD
|
|
KR20180118828A
(ko)
*
|
2008-10-24 |
2018-10-31 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
Dmd를 위한 다중 엑손 스키핑 조성물
|
|
DK2607484T3
(en)
|
2008-10-27 |
2016-03-07 |
Biomarin Technologies B V |
Methods and means for efficient skipping of exon 45 in Duchenne muscular dystrophy pre-MRNA
|
|
KR101602431B1
(ko)
|
2008-11-05 |
2016-03-10 |
삼성전자 주식회사 |
냉장고
|
|
CA2744987C
(en)
|
2008-12-02 |
2018-01-16 |
Chiralgen, Ltd. |
Method for the synthesis of phosphorus atom modified nucleic acids
|
|
US20130115603A9
(en)
|
2009-04-02 |
2013-05-09 |
Regents Of The University Of Minnesota |
Nucleotide repeat expansion-associated polypeptides and uses thereof
|
|
CN102625840A
(zh)
*
|
2009-04-10 |
2012-08-01 |
肌肉学研究协会 |
用于治疗疾病的三环dna反义寡核苷酸、组合物和方法
|
|
WO2010123369A1
(en)
|
2009-04-24 |
2010-10-28 |
Prosensa Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
WO2010129666A1
(en)
|
2009-05-05 |
2010-11-11 |
Altermune Technologies, Llc |
Chemically programmable immunity
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
WO2011024077A2
(en)
|
2009-08-31 |
2011-03-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Exon skipping therapy for functional amelioration of semi functional dystrophin in becker and duchenne muscular dystrophy
|
|
TR201804897T4
(tr)
|
2009-10-07 |
2018-06-21 |
Macrogenics Inc |
Fukosi̇lasyon ölçüsünün deği̇şi̇mleri̇nden dolayi geli̇şmi̇ş efektör i̇şlevi̇ sergi̇leyen fc bölgesi̇ni̇ i̇çeren poli̇pepti̇tler ve bunlarin kullanimlarina yöneli̇k yöntemler
|
|
EP3431603A1
(en)
*
|
2009-11-12 |
2019-01-23 |
The University Of Western Australia |
Antisense molecules and methods for treating pathologies
|
|
WO2011078797A2
(en)
*
|
2009-12-22 |
2011-06-30 |
Singapore Health Services Pte. Ltd |
Antisense oligonucleotides and uses threreof
|
|
US8697688B2
(en)
|
2010-04-15 |
2014-04-15 |
Seattle Genetics Inc. |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
MX2012011900A
(es)
|
2010-04-15 |
2013-03-21 |
Seattle Genetics Inc |
Conjugados de pirrolobenzodiazepina diana.
|
|
CN107353317A
(zh)
|
2010-05-28 |
2017-11-17 |
萨勒普塔医疗公司 |
具有修饰的亚基间键和/或端基的寡核苷酸类似物
|
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
US8936910B2
(en)
|
2010-06-11 |
2015-01-20 |
Antisense Pharma Gmbh |
Method for selective oligonucleotide modification
|
|
CN103167883B
(zh)
|
2010-07-19 |
2016-08-03 |
F·C·贝内特 |
肌强直性营养障碍蛋白激酶(dmpk)表达的调节
|
|
ES2663009T3
(es)
|
2010-10-29 |
2018-04-10 |
Sirna Therapeutics, Inc. |
Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
|
|
US8501930B2
(en)
*
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
EP2672977A1
(en)
|
2011-02-08 |
2013-12-18 |
The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System |
Antisense oligonucleotides
|
|
SI2691417T2
(sl)
|
2011-03-29 |
2025-05-30 |
Roche Glycart Ag |
FC variante protitelesa
|
|
US20140128449A1
(en)
|
2011-04-07 |
2014-05-08 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
EP2708560A4
(en)
|
2011-05-09 |
2015-01-14 |
Perseus Proteomics Inc |
ANTIBODIES FOR THE SPECIFIC DETECTION OF TRANSFERRIN RECEPTORS
|
|
US10100305B2
(en)
|
2011-07-15 |
2018-10-16 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
|
|
WO2013012758A1
(en)
|
2011-07-19 |
2013-01-24 |
Ontorii, Inc. |
Methods for the synthesis of functionalized nucleic acids
|
|
US9418216B2
(en)
|
2011-07-21 |
2016-08-16 |
Microsoft Technology Licensing, Llc |
Cloud service authentication
|
|
ES2876939T3
(es)
|
2011-08-30 |
2021-11-15 |
Res & Innovation Uk |
Péptidos penetradores de células que tienen un dominio hidrófobo central
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
KR102853694B1
(ko)
|
2011-11-18 |
2025-09-03 |
알닐람 파마슈티칼스 인코포레이티드 |
변형된 RNAi 제제
|
|
JP2015509922A
(ja)
*
|
2012-01-27 |
2015-04-02 |
プロセンサ テクノロジーズ ビー.ブイ.Prosensa Technologies B.V. |
デュシェンヌ型及びベッカー型筋ジストロフィーの治療のための改善された特徴を有するrna調節オリゴヌクレオチド
|
|
EP2814512A1
(en)
|
2012-02-16 |
2014-12-24 |
UCL Business Plc. |
Lysosome-cleavable linker
|
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
|
WO2013173391A1
(en)
|
2012-05-15 |
2013-11-21 |
Concortis Biosystems, Corp |
Drug-conjugates, conjugation methods, and uses thereof
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
CN110257379B
(zh)
*
|
2012-07-03 |
2023-08-11 |
马林生物科技有限公司 |
用于治疗肌肉萎缩症患者的寡核苷酸
|
|
KR102712879B1
(ko)
|
2012-07-13 |
2024-10-04 |
웨이브 라이프 사이언시스 리미티드 |
키랄 제어
|
|
DK2839860T3
(da)
|
2012-10-12 |
2019-06-17 |
Medimmune Ltd |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
JP6133431B2
(ja)
|
2012-11-24 |
2017-05-24 |
ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. |
親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
|
|
EA201591178A1
(ru)
|
2012-12-20 |
2015-11-30 |
Сарепта Терапьютикс, Инк. |
Улучшенные композиции для пропускания экзона для лечения мышечной дистрофии
|
|
MX379355B
(es)
|
2012-12-21 |
2025-03-11 |
Altrubio Inc |
Enlazadores autodestructivos hidrofilos y conjugados de los mismos.
|
|
US9481905B2
(en)
|
2013-02-19 |
2016-11-01 |
Orizhan Bioscience Limited |
Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
|
|
US9319764B2
(en)
|
2013-03-08 |
2016-04-19 |
Merry Electronics Co., Ltd. |
MEMS microphone packaging structure
|
|
KR20230116945A
(ko)
|
2013-03-14 |
2023-08-04 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
근육 이영양증의 치료를 위한 엑손 스키핑 조성물
|
|
CA2902872A1
(en)
|
2013-03-15 |
2014-09-18 |
Regeneron Pharmaceuticals, Inc. |
Biologically active molecules, conjugates thereof, and therapeutic uses
|
|
BR112015022998A2
(pt)
|
2013-03-15 |
2017-11-14 |
Sarepta Therapeutics Inc |
composições melhoradas para o tratamento de distrofia muscular
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
US9577459B2
(en)
|
2013-03-15 |
2017-02-21 |
Sequana Medical Ag |
Systems and methods for regulating inductive energy transfer to an implantable system
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
US9849066B2
(en)
|
2013-04-24 |
2017-12-26 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
CN105722851A
(zh)
|
2013-04-28 |
2016-06-29 |
秦刚 |
一种新型的连接子及其制备方法和用途
|
|
IL242088B2
(en)
|
2013-05-20 |
2023-12-01 |
Genentech Inc |
Anti-transferrin receptor antibodies and methods of use
|
|
BR112015029788B1
(pt)
|
2013-05-31 |
2024-01-02 |
Zymeworks Inc |
HETERO-MULTÍMERO, USO E MÉTODO PARA PREPARAR DO MESMO, COMPOSIÇÃO FARMACÊUTICA E MÉTODO PARA REDUZIR FUNÇÃO EFETORA DE UM CONSTRUTO IgG FC
|
|
US10704060B2
(en)
*
|
2013-06-05 |
2020-07-07 |
Duke University |
RNA-guided gene editing and gene regulation
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
US9982260B2
(en)
|
2013-09-30 |
2018-05-29 |
The Regents Of The University Of California |
Identification of structurally similar small molecules that enhance therapeutic exon skipping
|
|
AU2014337555C1
(en)
|
2013-10-15 |
2021-01-28 |
Seagen Inc. |
PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics
|
|
CN106132431A
(zh)
|
2013-10-15 |
2016-11-16 |
索伦托治疗有限公司 |
具有靶向分子和两种不同药物的药物偶联物
|
|
US10239957B2
(en)
|
2013-11-06 |
2019-03-26 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
|
WO2015075747A1
(en)
|
2013-11-19 |
2015-05-28 |
Council Of Scientific And Industrial Research |
Cell-penetrating peptide for biomolecule delivery
|
|
EP4137572A1
(en)
|
2014-01-16 |
2023-02-22 |
Wave Life Sciences Ltd. |
Chiral design
|
|
LT3118311T
(lt)
|
2014-03-12 |
2019-04-10 |
Nippon Shinyaku Co., Ltd. |
Priešprasminė nukleorūgštis
|
|
MY194170A
(en)
|
2014-06-17 |
2022-11-16 |
Nippon Shinyaku Co Ltd |
Antisense nucleic acids
|
|
US20180305689A1
(en)
|
2015-04-22 |
2018-10-25 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
EP3297649B1
(en)
|
2015-05-19 |
2023-10-11 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
UA123053C2
(uk)
|
2015-06-24 |
2021-02-10 |
Ф. Хоффманн-Ля Рош Аг |
Антитіло до рецептора трансферину зі спеціально підібраною афінністю
|
|
EP3653216A1
(en)
*
|
2015-09-30 |
2020-05-20 |
Sarepta Therapeutics, Inc. |
Methods for treating muscular dystrophy
|
|
GB2545898B
(en)
|
2015-12-21 |
2019-10-09 |
Sutura Therapeutics Ltd |
Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides
|
|
EP3423491A1
(en)
|
2016-03-01 |
2019-01-09 |
H. Hoffnabb-La Roche Ag |
Obinutuzumab variants having altered cell death induction
|
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
|
MA45290A
(fr)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
Procédés et compositions d'agents biologiquement actifs
|
|
US20190240346A1
(en)
|
2016-06-20 |
2019-08-08 |
Genahead Bio, Inc. |
Antibody-drug conjugate
|
|
EP3478829A1
(en)
|
2016-06-29 |
2019-05-08 |
Crispr Therapeutics AG |
Materials and methods for treatment of myotonic dystrophy type 1 (dm1) and other related disorders
|
|
MX2019006882A
(es)
*
|
2016-12-19 |
2019-08-16 |
Sarepta Therapeutics Inc |
Conjugados de oligomeros de omision de exon para distrofia muscular.
|
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
CN111770757A
(zh)
|
2017-09-22 |
2020-10-13 |
艾维迪提生物科学公司 |
诱导外显子跳读的核酸-多肽组合物和方法
|
|
WO2019113393A1
(en)
|
2017-12-06 |
2019-06-13 |
Avidity Biosciences Llc |
Compositions and methods of treating muscle atrophy and myotonic dystrophy
|
|
IL319265A
(en)
|
2018-12-21 |
2025-04-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and their uses
|
|
AU2020263487A1
(en)
|
2019-04-25 |
2021-12-16 |
Avidity Biosciences, Inc. |
Nucleic acid compositions and methods of multi-exon skipping
|
|
US20220288218A1
(en)
*
|
2019-07-09 |
2022-09-15 |
The Governors Of The University Of Alberta |
Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the dmd gene
|