JP2025120179A5 - - Google Patents
Info
- Publication number
- JP2025120179A5 JP2025120179A5 JP2025077567A JP2025077567A JP2025120179A5 JP 2025120179 A5 JP2025120179 A5 JP 2025120179A5 JP 2025077567 A JP2025077567 A JP 2025077567A JP 2025077567 A JP2025077567 A JP 2025077567A JP 2025120179 A5 JP2025120179 A5 JP 2025120179A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- immunoglobulin
- heavy chain
- region
- regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19173633.9 | 2019-05-09 | ||
| EP19173633 | 2019-05-09 | ||
| JP2021566278A JP7760377B2 (ja) | 2019-05-09 | 2020-05-08 | タンパク質を多量体化する変異体ドメイン及びその分離 |
| PCT/NL2020/050298 WO2020226502A2 (en) | 2019-05-09 | 2020-05-08 | Variant domains for multimerizing proteins and separation thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021566278A Division JP7760377B2 (ja) | 2019-05-09 | 2020-05-08 | タンパク質を多量体化する変異体ドメイン及びその分離 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025120179A JP2025120179A (ja) | 2025-08-15 |
| JP2025120179A5 true JP2025120179A5 (https=) | 2026-02-12 |
Family
ID=66476558
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021566278A Active JP7760377B2 (ja) | 2019-05-09 | 2020-05-08 | タンパク質を多量体化する変異体ドメイン及びその分離 |
| JP2025077567A Pending JP2025120179A (ja) | 2019-05-09 | 2025-05-07 | タンパク質を多量体化する変異体ドメイン及びその分離 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021566278A Active JP7760377B2 (ja) | 2019-05-09 | 2020-05-08 | タンパク質を多量体化する変異体ドメイン及びその分離 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20210054049A1 (https=) |
| EP (1) | EP3966238A2 (https=) |
| JP (2) | JP7760377B2 (https=) |
| KR (1) | KR20220017909A (https=) |
| CN (2) | CN114702587A (https=) |
| AR (1) | AR118898A1 (https=) |
| AU (2) | AU2020268684C1 (https=) |
| BR (1) | BR112021022405A2 (https=) |
| CA (1) | CA3139402A1 (https=) |
| IL (1) | IL287928A (https=) |
| MA (1) | MA55884A (https=) |
| MX (1) | MX2021013646A (https=) |
| PH (1) | PH12021552833A1 (https=) |
| SG (1) | SG11202112399PA (https=) |
| TW (1) | TW202108613A (https=) |
| WO (1) | WO2020226502A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA52212A (fr) * | 2018-03-30 | 2021-02-17 | Merus Nv | Anticorps multivalent |
| EP4263597A2 (en) * | 2020-12-18 | 2023-10-25 | Kiniksa Pharmaceuticals, Ltd. | Protein compositions and methods for producing and using the same |
| KR20250129720A (ko) | 2022-12-27 | 2025-08-29 | 메뤼스 엔.페. | 이중특이적 단백질을 생성하는 방법 |
| TW202544033A (zh) | 2024-04-15 | 2025-11-16 | 荷蘭商美勒斯公司 | Ｃｄ３結合結構域 |
| WO2025230409A1 (en) | 2024-04-30 | 2025-11-06 | Merus N.V. | Multispecific antibody-drug conjugates |
| WO2025230410A1 (en) | 2024-04-30 | 2025-11-06 | Merus N.V. | Multispecific antibody-drug conjugates |
| WO2026013015A1 (en) | 2024-07-09 | 2026-01-15 | Merus N.V. | Multispecific binding moieties comprising calr and cd3 binding domains |
| WO2026018064A1 (en) | 2024-07-16 | 2026-01-22 | Merus N.V. | Multispecific multi-drug antibody-drug conjugates |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4801687A (en) | 1986-10-27 | 1989-01-31 | Bioprobe International, Inc. | Monoclonal antibody purification process using protein A |
| US5151504A (en) | 1989-11-17 | 1992-09-29 | E. R. Squibb & Sons, Inc. | Method for purification of monoclonal antibodies |
| US7135287B1 (en) * | 1999-10-02 | 2006-11-14 | Biosite, Inc. | Human antibodies |
| US6680209B1 (en) * | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
| CA2484930A1 (en) * | 2002-05-06 | 2003-11-13 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries |
| DK2314629T4 (da) | 2002-07-18 | 2023-02-06 | Merus Nv | Rekombinant produktion af blandinger af antistoffer |
| NZ542784A (en) * | 2002-08-19 | 2008-07-31 | Astrazeneca Ab | Antibodies directed to monocyte chemo-attractant protein-1 (MCP-1) and uses thereof |
| EP1737890A2 (en) * | 2004-03-24 | 2007-01-03 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
| EP1858925A2 (en) * | 2005-01-12 | 2007-11-28 | Xencor, Inc. | Antibodies and fc fusion proteins with altered immunogenicity |
| EP2009101B1 (en) * | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| WO2008027236A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Multispecific antibodies |
| ES2595638T3 (es) * | 2007-09-26 | 2017-01-02 | Chugai Seiyaku Kabushiki Kaisha | Método para modificar el punto isoeléctrico de un anticuerpo mediante la sustitución de aminoácidos en una CDR |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| EP2147594B1 (en) | 2008-06-27 | 2013-11-13 | Merus B.V. | Antibody producing non-human mammals |
| MY152068A (en) | 2009-03-20 | 2014-08-15 | Genentech Inc | Bispecific anti-her antibodies |
| BR112013023918A2 (pt) * | 2011-03-25 | 2016-12-13 | Glenmark Pharmaceuticals Sa | imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para produzir uma imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para construir uma interface proteína-proteína de um domínio de uma proteína de múltiplos domínios e uso de um domínio doador de um primeiro e de um segundo membro de uma super-família de imunoglobulina de ocorrência natural |
| TW201817744A (zh) * | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| AU2012323287B2 (en) * | 2011-10-10 | 2018-02-01 | Xencor, Inc. | A method for purifying antibodies |
| CN109134658B (zh) * | 2011-10-31 | 2022-10-14 | 中外制药株式会社 | 控制了重链与轻链的缔合的抗原结合分子 |
| US9248181B2 (en) * | 2012-04-20 | 2016-02-02 | Merus B.V. | Methods and means for the production of Ig-like molecules |
| CN104045714B (zh) * | 2013-03-14 | 2019-01-11 | 南京金斯瑞生物科技有限公司 | 曲妥珠单抗突变体IgG及其应用 |
| JP6594855B2 (ja) * | 2013-03-15 | 2019-10-23 | ゼンコア インコーポレイテッド | ヘテロ二量体タンパク質 |
| JP6771385B2 (ja) | 2014-02-28 | 2020-10-21 | メルス ナムローゼ フェンノートシャップ | 二重特異性抗体および医薬組成物 |
| EP3174897B1 (en) * | 2014-07-29 | 2020-02-12 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
| MA41375A (fr) * | 2015-01-22 | 2017-11-28 | Lilly Co Eli | Anticorps igg bispécifiques et leurs procédés de préparation |
| MY202858A (en) * | 2016-06-10 | 2024-05-25 | Eisai R&D Man Co Ltd | Lysine conjugated immunoglobulins |
| WO2017218698A1 (en) * | 2016-06-15 | 2017-12-21 | Sutro Biopharma, Inc. | Antibodies with engineered ch2 domains, compositions thereof and methods of using the same |
| CN118027197A (zh) | 2017-07-06 | 2024-05-14 | 美勒斯公司 | 调节由细胞表达的生物活性的抗体 |
| MX2020000055A (es) | 2017-07-06 | 2020-08-06 | Merus Nv | Anticuerpos biespecificos antiproteina 1 de muerte celular programada (pd-1) -anti inmunoglobulina de celulas t y dominio de mucina que contiene -3 (tim-3). |
| AU2018296067B2 (en) | 2017-07-06 | 2021-06-10 | Merus B.V. | Binding molecules that modulate a biological activity expressed by a cell |
| SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
| WO2019148412A1 (en) * | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| WO2019148410A1 (en) * | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1 antibodies |
| MA52212A (fr) | 2018-03-30 | 2021-02-17 | Merus Nv | Anticorps multivalent |
| CN110272495A (zh) * | 2019-06-11 | 2019-09-24 | 南京华岩生物技术有限公司 | 一种能结合两种抗原的双特异性结合的免疫球蛋白及其用途 |
-
2020
- 2020-05-08 AU AU2020268684A patent/AU2020268684C1/en active Active
- 2020-05-08 KR KR1020217039330A patent/KR20220017909A/ko active Pending
- 2020-05-08 JP JP2021566278A patent/JP7760377B2/ja active Active
- 2020-05-08 CN CN202210393772.0A patent/CN114702587A/zh active Pending
- 2020-05-08 WO PCT/NL2020/050298 patent/WO2020226502A2/en not_active Ceased
- 2020-05-08 SG SG11202112399PA patent/SG11202112399PA/en unknown
- 2020-05-08 AR ARP200101330A patent/AR118898A1/es unknown
- 2020-05-08 US US16/870,715 patent/US20210054049A1/en active Pending
- 2020-05-08 MA MA055884A patent/MA55884A/fr unknown
- 2020-05-08 PH PH1/2021/552833A patent/PH12021552833A1/en unknown
- 2020-05-08 EP EP20727737.7A patent/EP3966238A2/en active Pending
- 2020-05-08 TW TW109115418A patent/TW202108613A/zh unknown
- 2020-05-08 CN CN202080048983.XA patent/CN114430745A/zh active Pending
- 2020-05-08 MX MX2021013646A patent/MX2021013646A/es unknown
- 2020-05-08 BR BR112021022405A patent/BR112021022405A2/pt unknown
- 2020-05-08 CA CA3139402A patent/CA3139402A1/en active Pending
-
2021
- 2021-11-08 IL IL287928A patent/IL287928A/en unknown
-
2025
- 2025-05-07 JP JP2025077567A patent/JP2025120179A/ja active Pending
- 2025-07-25 AU AU2025208511A patent/AU2025208511A1/en active Pending
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