|
CA1293460C
(en)
|
1985-10-07 |
1991-12-24 |
Brian Lee Sauer |
Site-specific recombination of dna in yeast
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
GB8904009D0
(en)
|
1989-02-22 |
1989-04-05 |
Celltech Ltd |
Vector
|
|
US5464764A
(en)
|
1989-08-22 |
1995-11-07 |
University Of Utah Research Foundation |
Positive-negative selection methods and vectors
|
|
US6689610B1
(en)
|
1989-08-22 |
2004-02-10 |
University Of Utah Research Foundation |
Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US7041871B1
(en)
|
1995-10-10 |
2006-05-09 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE352612T1
(de)
|
1990-08-29 |
2007-02-15 |
Pharming Intellectual Pty Bv |
Homologe rekombination in säugetier-zellen
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
WO1992015694A1
(en)
|
1991-03-08 |
1992-09-17 |
The Salk Institute For Biological Studies |
Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
|
|
DE4228162C1
(de)
|
1992-08-25 |
1994-01-13 |
Rajewsky Klaus Dr |
Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
|
|
US5593598A
(en)
|
1994-04-20 |
1997-01-14 |
Mcginness; Michael P. |
Method and apparatus for closed loop recycling of contaminated cleaning solution
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6091001A
(en)
|
1995-03-29 |
2000-07-18 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US6774279B2
(en)
|
1997-05-30 |
2004-08-10 |
Carnegie Institution Of Washington |
Use of FLP recombinase in mice
|
|
FR2814642B1
(fr)
|
2000-10-03 |
2005-07-01 |
Ass Pour Le Dev De La Rech En |
Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US7422889B2
(en)
|
2004-10-29 |
2008-09-09 |
Stowers Institute For Medical Research |
Dre recombinase and recombinase systems employing Dre recombinase
|
|
US10662256B2
(en)
*
|
2010-07-26 |
2020-05-26 |
Trianni, Inc. |
Transgenic mammals and methods of use thereof
|
|
US20170058052A1
(en)
|
2015-08-24 |
2017-03-02 |
Trianni, Inc. |
Enhanced production of immunoglobulins
|
|
WO2018128691A1
(en)
*
|
2016-11-04 |
2018-07-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having an engineered immunoglobulin lambda light chain locus
|
|
GB2561352B
(en)
*
|
2017-04-10 |
2023-01-18 |
Genome Res Ltd |
Animal models and therapeutic molecules
|
|
GB2578867A
(en)
*
|
2018-10-09 |
2020-06-03 |
Genome Res Ltd |
Animal models and therapeutic molecules
|
|
CA3144956A1
(en)
*
|
2019-07-01 |
2021-01-07 |
Trianni, Inc. |
Transgenic mammals and methods of use
|
|
WO2021003152A1
(en)
*
|
2019-07-01 |
2021-01-07 |
Trianni, Inc. |
Transgenic mammals and methods of use thereof
|