JP2022538885A5 - - Google Patents
Info
- Publication number
- JP2022538885A5 JP2022538885A5 JP2021577914A JP2021577914A JP2022538885A5 JP 2022538885 A5 JP2022538885 A5 JP 2022538885A5 JP 2021577914 A JP2021577914 A JP 2021577914A JP 2021577914 A JP2021577914 A JP 2021577914A JP 2022538885 A5 JP2022538885 A5 JP 2022538885A5
- Authority
- JP
- Japan
- Prior art keywords
- rodent
- immunoglobulin
- bovine
- transgenic
- gene segment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025162945A JP2026026076A (ja) | 2019-07-01 | 2025-09-30 | トランスジェニック哺乳動物およびその使用法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962869415P | 2019-07-01 | 2019-07-01 | |
| US62/869,415 | 2019-07-01 | ||
| PCT/US2020/040290 WO2021003152A1 (en) | 2019-07-01 | 2020-06-30 | Transgenic mammals and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025162945A Division JP2026026076A (ja) | 2019-07-01 | 2025-09-30 | トランスジェニック哺乳動物およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022538885A JP2022538885A (ja) | 2022-09-06 |
| JP2022538885A5 true JP2022538885A5 (https=) | 2023-07-07 |
| JP7752536B2 JP7752536B2 (ja) | 2025-10-10 |
Family
ID=71846497
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021577914A Active JP7752536B2 (ja) | 2019-07-01 | 2020-06-30 | トランスジェニック哺乳動物およびその使用法 |
| JP2025162945A Pending JP2026026076A (ja) | 2019-07-01 | 2025-09-30 | トランスジェニック哺乳動物およびその使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025162945A Pending JP2026026076A (ja) | 2019-07-01 | 2025-09-30 | トランスジェニック哺乳動物およびその使用法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220369609A1 (https=) |
| EP (2) | EP4567118A3 (https=) |
| JP (2) | JP7752536B2 (https=) |
| CN (1) | CN114554841B (https=) |
| AU (1) | AU2020298458B2 (https=) |
| CA (1) | CA3144958A1 (https=) |
| DK (1) | DK3993623T3 (https=) |
| ES (1) | ES3027509T3 (https=) |
| FI (1) | FI3993623T3 (https=) |
| IL (1) | IL289469A (https=) |
| PL (1) | PL3993623T3 (https=) |
| PT (1) | PT3993623T (https=) |
| WO (1) | WO2021003152A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3476942T3 (da) | 2017-10-27 | 2022-04-19 | Trianni Inc | Lange kimlinje-dh-gener og antistoffer med lang hcdr3 |
| WO2022235759A1 (en) * | 2021-05-05 | 2022-11-10 | Trianni, Inc. | Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof |
| US20250320520A1 (en) | 2021-10-01 | 2025-10-16 | Abcellera Biologics Inc. | Trangenic rodents for cell line identification and enrichment |
| KR20240110577A (ko) * | 2021-11-10 | 2024-07-15 | 트리아니, 인코포레이티드 | 유전자이식 포유동물 및 이의 사용 방법 |
| JP7748680B2 (ja) * | 2021-11-16 | 2025-10-03 | 国立大学法人鳥取大学 | 改変ｄ領域を含むヒト免疫グロブリン重鎖遺伝子座を有する哺乳動物人工染色体ベクター、及びそのベクターを保持する細胞又は非ヒト動物 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1293460C (en) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| GB8904009D0 (en) | 1989-02-22 | 1989-04-05 | Celltech Ltd | Vector |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US6689610B1 (en) | 1989-08-22 | 2004-02-10 | University Of Utah Research Foundation | Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| DE69133557D1 (de) | 1990-08-29 | 2007-03-15 | Pharming Intellectual Pty Bv | Homologe rekombination in säugetier-zellen |
| WO1992015694A1 (en) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
| DE4228162C1 (de) | 1992-08-25 | 1994-01-13 | Rajewsky Klaus Dr | Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern |
| US5593598A (en) | 1994-04-20 | 1997-01-14 | Mcginness; Michael P. | Method and apparatus for closed loop recycling of contaminated cleaning solution |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20080184380A1 (en) * | 2004-10-22 | 2008-07-31 | Therapeutic Human Polyclonals Inc. | Suppression of Endogenous Immunoglobulin Expression in Non-Human Transgenic Animals |
| US7422889B2 (en) | 2004-10-29 | 2008-09-09 | Stowers Institute For Medical Research | Dre recombinase and recombinase systems employing Dre recombinase |
| JP5827127B2 (ja) * | 2008-12-18 | 2015-12-02 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用 |
| PT3034608T (pt) * | 2010-06-22 | 2019-05-28 | Regeneron Pharma | Ratinhos expressando uma cadeia leve híbrida de imunoglobulina com uma região variável humana |
| US10793829B2 (en) * | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| CN103025884B (zh) | 2010-07-26 | 2015-11-25 | 特里安尼公司 | 转基因动物和使用方法 |
| SG10201605675WA (en) * | 2011-12-20 | 2016-09-29 | Regeneron Pharma | Humanized light chain mice |
| US9788534B2 (en) * | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| SG10201913483XA (en) * | 2016-11-04 | 2020-03-30 | Regeneron Pharma | Non-human animals having an engineered immunoglobulin lambda light chain locus |
| HUE060608T2 (hu) * | 2017-12-05 | 2023-03-28 | Regeneron Pharma | Genetikailag módosított immunglobulin lambda könnyûlánccal rendelkezõ egerek és azok alkalmazása |
-
2020
- 2020-06-30 DK DK20747552.6T patent/DK3993623T3/da active
- 2020-06-30 CA CA3144958A patent/CA3144958A1/en active Pending
- 2020-06-30 PL PL20747552.6T patent/PL3993623T3/pl unknown
- 2020-06-30 CN CN202080061466.6A patent/CN114554841B/zh active Active
- 2020-06-30 JP JP2021577914A patent/JP7752536B2/ja active Active
- 2020-06-30 EP EP25153185.1A patent/EP4567118A3/en active Pending
- 2020-06-30 WO PCT/US2020/040290 patent/WO2021003152A1/en not_active Ceased
- 2020-06-30 ES ES20747552T patent/ES3027509T3/es active Active
- 2020-06-30 AU AU2020298458A patent/AU2020298458B2/en active Active
- 2020-06-30 EP EP20747552.6A patent/EP3993623B1/en active Active
- 2020-06-30 PT PT207475526T patent/PT3993623T/pt unknown
- 2020-06-30 US US17/624,084 patent/US20220369609A1/en active Pending
- 2020-06-30 FI FIEP20747552.6T patent/FI3993623T3/fi active
-
2021
- 2021-12-28 IL IL289469A patent/IL289469A/en unknown
-
2025
- 2025-09-30 JP JP2025162945A patent/JP2026026076A/ja active Pending
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