JP2024516996A5 - - Google Patents

Info

Publication number
JP2024516996A5
JP2024516996A5 JP2023567910A JP2023567910A JP2024516996A5 JP 2024516996 A5 JP2024516996 A5 JP 2024516996A5 JP 2023567910 A JP2023567910 A JP 2023567910A JP 2023567910 A JP2023567910 A JP 2023567910A JP 2024516996 A5 JP2024516996 A5 JP 2024516996A5
Authority
JP
Japan
Prior art keywords
immunoglobulin
locus
equine
rodent
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023567910A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024516996A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/027622 external-priority patent/WO2022235759A1/en
Publication of JP2024516996A publication Critical patent/JP2024516996A/ja
Publication of JP2024516996A5 publication Critical patent/JP2024516996A5/ja
Pending legal-status Critical Current

Links

JP2023567910A 2021-05-05 2022-05-04 トランスジェニック哺乳動物およびその使用方法 Pending JP2024516996A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163184440P 2021-05-05 2021-05-05
US63/184,440 2021-05-05
PCT/US2022/027622 WO2022235759A1 (en) 2021-05-05 2022-05-04 Transgenic rodents expressing chimeric equine-rodent antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2024516996A JP2024516996A (ja) 2024-04-18
JP2024516996A5 true JP2024516996A5 (https=) 2025-05-14

Family

ID=81750504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023567910A Pending JP2024516996A (ja) 2021-05-05 2022-05-04 トランスジェニック哺乳動物およびその使用方法

Country Status (9)

Country Link
US (1) US20240215556A1 (https=)
EP (1) EP4333613A1 (https=)
JP (1) JP2024516996A (https=)
KR (1) KR20240004503A (https=)
CN (1) CN117440753A (https=)
AU (1) AU2022268937A1 (https=)
CA (1) CA3216988A1 (https=)
IL (1) IL307638A (https=)
WO (1) WO2022235759A1 (https=)

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293460C (en) 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
GB8904009D0 (en) 1989-02-22 1989-04-05 Celltech Ltd Vector
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US6689610B1 (en) 1989-08-22 2004-02-10 University Of Utah Research Foundation Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
DE4228162C1 (de) 1992-08-25 1994-01-13 Rajewsky Klaus Dr Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern
US5593598A (en) 1994-04-20 1997-01-14 Mcginness; Michael P. Method and apparatus for closed loop recycling of contaminated cleaning solution
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7422889B2 (en) 2004-10-29 2008-09-09 Stowers Institute For Medical Research Dre recombinase and recombinase systems employing Dre recombinase
PE20081216A1 (es) * 2006-09-01 2008-09-04 Therapeutic Human Polyclonals Inc Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos
CN103025884B (zh) * 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
GB2528811A (en) * 2011-05-06 2016-02-03 Nvip Pty Ltd Anti-nerve growth factor antibodies and methods of preparing and using the same
JP2018525007A (ja) 2015-08-24 2018-09-06 トリアンニ インコーポレイテッドTrianni,Inc. 免疫グロブリンの産生増強
GB2561352B (en) * 2017-04-10 2023-01-18 Genome Res Ltd Animal models and therapeutic molecules
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules
CN114502725B (zh) * 2019-07-01 2025-09-12 特里安尼公司 转基因哺乳动物及使用方法
DK3993623T3 (da) * 2019-07-01 2025-05-26 Zoetis Services Llc Transgene gnavere og fremgangsmåder til anvendelse deraf

Similar Documents

Publication Publication Date Title
AU2021200079B2 (en) Animal models and therapeutic molecules
AU2009298458B2 (en) Non-human mammals for the production of chimeric antibodies
DK2553100T3 (en) REPLACING NON-HUMAN ANIMALS TO CREATE CHIMERARY ANTIBODIES
EP1597382B1 (en) Genetically modified non-human mammals and cells
JP2018525014A (ja) 共通の軽鎖を有する抗体を産生するためのトランスジェニック動物
JP2024516996A5 (https=)
AU2019237926A1 (en) Transgenic chicken that produces human antibodies
JP2024543248A5 (https=)
JP2024543248A (ja) トランスジェニック哺乳動物およびその使用方法
JP2024518435A5 (https=)
JP2024516996A (ja) トランスジェニック哺乳動物およびその使用方法
JPWO2023090361A5 (https=)
HK1231692B (en) Non-human animals that make single domain binding proteins