JPWO2023090361A5 - - Google Patents

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Publication number
JPWO2023090361A5
JPWO2023090361A5 JP2023562377A JP2023562377A JPWO2023090361A5 JP WO2023090361 A5 JPWO2023090361 A5 JP WO2023090361A5 JP 2023562377 A JP2023562377 A JP 2023562377A JP 2023562377 A JP2023562377 A JP 2023562377A JP WO2023090361 A5 JPWO2023090361 A5 JP WO2023090361A5
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JP
Japan
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region
sequence
heavy chain
immunoglobulin heavy
human
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JP2023562377A
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English (en)
Japanese (ja)
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JPWO2023090361A1 (https=
JP7748680B2 (ja
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Priority claimed from PCT/JP2022/042560 external-priority patent/WO2023090361A1/ja
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JP2023562377A 2021-11-16 2022-11-16 改変ｄ領域を含むヒト免疫グロブリン重鎖遺伝子座を有する哺乳動物人工染色体ベクター、及びそのベクターを保持する細胞又は非ヒト動物 Active JP7748680B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021186124 2021-11-16
JP2021186124 2021-11-16
PCT/JP2022/042560 WO2023090361A1 (ja) 2021-11-16 2022-11-16 改変ｄ領域を含むヒト免疫グロブリン重鎖遺伝子座を有する哺乳動物人工染色体ベクター、及びそのベクターを保持する細胞又は非ヒト動物

Publications (3)

Publication Number Publication Date
JPWO2023090361A1 JPWO2023090361A1 (https=) 2023-05-25
JPWO2023090361A5 true JPWO2023090361A5 (https=) 2024-05-23
JP7748680B2 JP7748680B2 (ja) 2025-10-03

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ID=86397075

Family Applications (1)

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JP2023562377A Active JP7748680B2 (ja) 2021-11-16 2022-11-16 改変ｄ領域を含むヒト免疫グロブリン重鎖遺伝子座を有する哺乳動物人工染色体ベクター、及びそのベクターを保持する細胞又は非ヒト動物

Country Status (4)

Country Link
US (1) US20240392313A1 (https=)
EP (1) EP4389895A4 (https=)
JP (1) JP7748680B2 (https=)
WO (1) WO2023090361A1 (https=)

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665025B2 (en) 1991-09-23 1995-12-14 Cambridge Antibody Technology Limited Production of chimeric antibodies - a combinatorial approach
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
DE69333823T2 (de) 1992-03-24 2006-05-04 Cambridge Antibody Technology Ltd., Melbourn Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (en) 1993-12-03 1996-09-18 Medical Research Council Recombinant binding proteins and peptides
WO1997007671A1 (en) 1995-08-29 1997-03-06 Kirin Beer Kabushiki Kaisha Chimeric animal and method for constructing the same
JP4082740B2 (ja) 1997-02-28 2008-04-30 キリンファーマ株式会社 内因性遺伝子が破壊されている分化多能性保持細胞
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
BRPI0619794B8 (pt) 2005-12-13 2022-06-14 Univ Kyoto Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
WO2009097006A2 (en) 2007-08-10 2009-08-06 Medarex, Inc. Hco32 and hco27 and related examples
KR102203727B1 (ko) * 2010-03-31 2021-01-18 아블렉시스, 엘엘씨 키메라 항체의 제조를 위한 비-인간 동물의 유전적 조작
US10793829B2 (en) * 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
JP6482757B2 (ja) 2010-07-26 2019-03-13 トリアンニ インコーポレイテッドＴｒｉａｎｎｉ，Ｉｎｃ． トランスジェニック動物および使用方法
BR112014006394A2 (pt) 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
CN109906272A (zh) 2016-10-31 2019-06-18 国立大学法人鸟取大学 产生人抗体的非人动物和使用该非人动物的人抗体制作方法
JP6775224B2 (ja) 2018-03-16 2020-10-28 国立大学法人鳥取大学 マウス人工染色体ベクター及びその使用
WO2021003152A1 (en) 2019-07-01 2021-01-07 Trianni, Inc. Transgenic mammals and methods of use thereof
JP7235005B2 (ja) 2020-05-27 2023-03-08 株式会社三洋物産 遊技機

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