JP2024534900A - ホスファチジルセリンを含む核酸を送達するための新規な脂質ナノ粒子 - Google Patents

ホスファチジルセリンを含む核酸を送達するための新規な脂質ナノ粒子 Download PDF

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JP2024534900A
JP2024534900A JP2024514020A JP2024514020A JP2024534900A JP 2024534900 A JP2024534900 A JP 2024534900A JP 2024514020 A JP2024514020 A JP 2024514020A JP 2024514020 A JP2024514020 A JP 2024514020A JP 2024534900 A JP2024534900 A JP 2024534900A
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lipid
amount
glycero
vaccine composition
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JP2024534900A5 (enExample
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バウムホフ、パトリック
ナバロ、ジェマ
メンデス、リビア パーマストン
リュッケルト、クリスティーネ
ラザロ、サンドラ
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CureVac SE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024514020A 2021-09-03 2022-09-02 ホスファチジルセリンを含む核酸を送達するための新規な脂質ナノ粒子 Pending JP2024534900A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2021074342 2021-09-03
EPPCT/EP2021/074342 2021-09-03
PCT/EP2022/074435 WO2023031392A2 (en) 2021-09-03 2022-09-02 Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine

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JP2024534900A true JP2024534900A (ja) 2024-09-26
JP2024534900A5 JP2024534900A5 (enExample) 2026-03-26

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US (1) US20240398933A1 (enExample)
EP (1) EP4395820A2 (enExample)
JP (1) JP2024534900A (enExample)
CN (1) CN117940158A (enExample)
AU (1) AU2022336664B2 (enExample)
CA (1) CA3230056A1 (enExample)
IL (1) IL309502A (enExample)
MX (1) MX2024002725A (enExample)
WO (1) WO2023031392A2 (enExample)

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CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
CN117098541A (zh) 2020-11-25 2023-11-21 阿卡格拉医药公司 用于递送核酸的脂质纳米粒及相关使用方法
CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
DE102022002240A1 (de) * 2022-06-21 2023-12-21 Friedrich-Schiller-Universität Jena, Körperschaft des öffentlichen Rechts Poly(oxazolin)- und Poly(oxazin)-basierte Lipide, Verfahren zu deren Herstellung und deren Verwendung
CN119095585A (zh) * 2022-12-21 2024-12-06 苏州艾博生物科技有限公司 包含固醇修饰的磷脂的脂质纳米颗粒
AU2024285035A1 (en) * 2023-06-09 2026-01-15 Rinuagene Biotechnology Co., Ltd. Expression-adjustable engineered rna molecule
CN117599160A (zh) * 2023-11-29 2024-02-27 复旦大学附属中山医院 狂犬病疫苗免疫原组合物
WO2025160381A1 (en) * 2024-01-26 2025-07-31 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2025229369A1 (ko) * 2024-05-02 2025-11-06 삼성바이오로직스 주식회사 합성 핵산 분자 및 이의 용도
CN118844387A (zh) * 2024-06-24 2024-10-29 浙江大学 含有包裹Mms6 mRNA的脂质纳米颗粒的非靶向巨噬细胞及其应用
CN118844385A (zh) * 2024-06-24 2024-10-29 浙江大学 含有包裹Mms6 mRNA的脂质纳米颗粒的靶向巨噬细胞及其应用
WO2026006277A2 (en) 2024-06-25 2026-01-02 Massachusetts Institute Of Technology Viral subunit vaccines
WO2026129142A1 (zh) * 2024-12-17 2026-06-25 西湖实验室(生命科学和生物医学浙江省实验室) 新型脂质纳米颗粒系统、car-t构建方法及其应用

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