CA3230056A1 - Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine - Google Patents

Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine Download PDF

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Publication number
CA3230056A1
CA3230056A1 CA3230056A CA3230056A CA3230056A1 CA 3230056 A1 CA3230056 A1 CA 3230056A1 CA 3230056 A CA3230056 A CA 3230056A CA 3230056 A CA3230056 A CA 3230056A CA 3230056 A1 CA3230056 A1 CA 3230056A1
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CA
Canada
Prior art keywords
mol
lipid
amount
vaccine composition
glycero
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Pending
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CA3230056A
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English (en)
French (fr)
Inventor
Patrick Baumhof
Gemma NAVARRO
Livia PALMERSTON MENDES
Christine Ruckert
Sandra LAZZARO
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CureVac SE
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CureVac SE
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Publication of CA3230056A1 publication Critical patent/CA3230056A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3230056A 2021-09-03 2022-09-02 Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine Pending CA3230056A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2021074342 2021-09-03
EPPCT/EP2021/074342 2021-09-03
PCT/EP2022/074435 WO2023031392A2 (en) 2021-09-03 2022-09-02 Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine

Publications (1)

Publication Number Publication Date
CA3230056A1 true CA3230056A1 (en) 2023-03-09

Family

ID=77864535

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3230056A Pending CA3230056A1 (en) 2021-09-03 2022-09-02 Novel lipid nanoparticles for delivery of nucleic acids comprising phosphatidylserine

Country Status (9)

Country Link
US (1) US20240398933A1 (enExample)
EP (1) EP4395820A2 (enExample)
JP (1) JP2024534900A (enExample)
CN (1) CN117940158A (enExample)
AU (1) AU2022336664B2 (enExample)
CA (1) CA3230056A1 (enExample)
IL (1) IL309502A (enExample)
MX (1) MX2024002725A (enExample)
WO (1) WO2023031392A2 (enExample)

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CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
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WO2023031392A3 (en) 2023-04-13
JP2024534900A (ja) 2024-09-26
EP4395820A2 (en) 2024-07-10
AU2022336664A1 (en) 2024-01-18
US20240398933A1 (en) 2024-12-05
IL309502A (en) 2024-02-01
WO2023031392A2 (en) 2023-03-09
CN117940158A (zh) 2024-04-26
AU2022336664B2 (en) 2026-06-04
MX2024002725A (es) 2024-03-15

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