JP2024534840A5 - - Google Patents

Info

Publication number
JP2024534840A5
JP2024534840A5 JP2024513015A JP2024513015A JP2024534840A5 JP 2024534840 A5 JP2024534840 A5 JP 2024534840A5 JP 2024513015 A JP2024513015 A JP 2024513015A JP 2024513015 A JP2024513015 A JP 2024513015A JP 2024534840 A5 JP2024534840 A5 JP 2024534840A5
Authority
JP
Japan
Prior art keywords
alkyl
group
cycloalkyl
ring
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024513015A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024534840A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/075472 external-priority patent/WO2023028564A1/en
Publication of JP2024534840A publication Critical patent/JP2024534840A/ja
Publication of JP2024534840A5 publication Critical patent/JP2024534840A5/ja
Pending legal-status Critical Current

Links

JP2024513015A 2021-08-26 2022-08-25 Kif18aのスピロインドリン阻害剤 Pending JP2024534840A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163237275P 2021-08-26 2021-08-26
US63/237,275 2021-08-26
US202263306452P 2022-02-03 2022-02-03
US63/306,452 2022-02-03
US202263344435P 2022-05-20 2022-05-20
US63/344,435 2022-05-20
PCT/US2022/075472 WO2023028564A1 (en) 2021-08-26 2022-08-25 Spiro indoline inhibitors of kif18a

Publications (2)

Publication Number Publication Date
JP2024534840A JP2024534840A (ja) 2024-09-26
JP2024534840A5 true JP2024534840A5 (enExample) 2025-08-26

Family

ID=83457176

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024513015A Pending JP2024534840A (ja) 2021-08-26 2022-08-25 Kif18aのスピロインドリン阻害剤

Country Status (12)

Country Link
US (2) US12084420B2 (enExample)
EP (1) EP4392407A1 (enExample)
JP (1) JP2024534840A (enExample)
KR (1) KR20240109977A (enExample)
CN (1) CN119241504A (enExample)
AU (1) AU2022334480A1 (enExample)
CA (1) CA3230123A1 (enExample)
CL (1) CL2024000560A1 (enExample)
IL (1) IL310863A (enExample)
MX (1) MX2024002391A (enExample)
TW (1) TW202317092A (enExample)
WO (1) WO2023028564A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL283639B2 (en) 2018-12-20 2024-06-01 Amgen Inc Kif18a inhibitors
CR20250087A (es) 2022-08-18 2025-07-11 Accent Therapeutics Inc Inhibidores de kif18a y usos de estos
WO2024066986A1 (zh) * 2022-09-30 2024-04-04 楚浦创制(武汉)医药科技有限公司 2-氨基嘧啶类化合物及其应用、药用组合物
WO2024114730A1 (zh) * 2022-11-30 2024-06-06 微境生物医药科技(上海)有限公司 一种用于癌症治疗的药物组合物
AU2024226158A1 (en) * 2023-02-23 2025-08-14 Volastra Therapeutics, Inc. Solid formulations and polymorphic forms of indoline inhibitors of kif18a
WO2024188338A1 (zh) * 2023-03-16 2024-09-19 微境生物医药科技(上海)有限公司 Kif18a抑制剂
AU2024305256A1 (en) 2023-06-14 2026-01-15 Volastra Therapeutics, Inc. Method of treating cancer with indoline inhibitors of kif18a
WO2025190325A1 (zh) * 2024-03-13 2025-09-18 海南先声再明医药股份有限公司 Kif18a抑制剂和微管蛋白抑制剂的药物组合及用途

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
KR100477070B1 (ko) 1994-03-25 2006-04-21 이소테크니카 인코포레이티드 중수소화작용에의한의약품의효능강화법
US6534309B1 (en) 2000-08-03 2003-03-18 Cytokinetics, Inc. Motor proteins and methods for their use
AU2002231098A1 (en) 2000-12-15 2002-06-24 Emory University Nonpeptide agonists and antagonists of vasopressin receptors
EP1517904A4 (en) 2002-05-23 2007-02-21 Merck & Co Inc INHIBITORS OF MITOTIC KINESINE
EP2305813A3 (en) 2002-11-14 2012-03-28 Dharmacon, Inc. Fuctional and hyperfunctional sirna
US7423018B2 (en) 2002-12-13 2008-09-09 University Of Massachusetts Kinesin-like proteins and methods of use
US7638549B2 (en) 2003-08-15 2009-12-29 Merck & Co. Inc. Mitotic kinesin inhibitors
US7504413B2 (en) 2004-05-06 2009-03-17 Cytokinetics, Inc. N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
MXPA06014909A (es) 2004-06-18 2007-02-28 Chiron Corp Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer.
DE602005024572D1 (de) 2004-08-18 2010-12-16 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
WO2006114788A1 (en) 2005-04-25 2006-11-02 Ramot At Tel Aviv University Ltd. Kinesin polypeptides, polynucleotides encoding same and compositions and methods of using same
EP1942888A2 (en) 2005-11-02 2008-07-16 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
JP2009543770A (ja) 2006-07-14 2009-12-10 アステックス・セラピューティクス・リミテッド Cdk及びgskの阻害のためのピラゾール誘導体の組合せ剤
AR062200A1 (es) 2006-08-04 2008-10-22 Aeterna Zentaris Gmbh Derivados de antraceno y su uso para el tratamiento de emfermedades tumorales bengnas y malingnas
US20080051463A1 (en) 2006-08-04 2008-02-28 Aeterna Zentaris Gmbh Anthracene compounds and their use for treating benign and malignant tumor disorders
TW201103904A (en) 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
EP2295543A1 (en) 2009-09-11 2011-03-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the preparation of an influenza virus
WO2011085261A1 (en) 2010-01-08 2011-07-14 Selexagen Therapeutics, Inc. Hedgehog inhibitors
JP5111626B2 (ja) 2011-01-14 2013-01-09 Ntn株式会社 電動シートリクライニング用ころ軸受
CN102796103A (zh) 2011-05-23 2012-11-28 南京英派药业有限公司 6-(芳基甲酰)咪唑并[1,2-a]嘧啶和6-(芳基甲酰)[1,2,4]三唑并[4,3-a]嘧啶作为Hedgehog抑制剂及其应用
US9890430B2 (en) 2012-06-12 2018-02-13 Washington University Copy number aberration driven endocrine response gene signature
JP6098406B2 (ja) 2013-07-17 2017-03-22 Jfeスチール株式会社 溶接接合部および溶接接合方法
ES2672992T3 (es) 2013-08-09 2018-06-19 Takeda Pharmaceutical Company Limited Compuesto aromático
WO2015183776A1 (en) 2014-05-29 2015-12-03 Merck Sharp & Dohme Corp. Methods for treating cancer with a wee1 inhibitor
EP3233918A1 (en) 2014-12-19 2017-10-25 Novartis AG Combination therapies
WO2016168660A1 (en) * 2015-04-17 2016-10-20 Forma Therapeutics, Inc. 3-spiro-7-hydroxamic acid tetralins as hdac inhibitors
CN106795149B (zh) 2015-05-05 2019-09-24 上海海雁医药科技有限公司 双环取代的苯磺酰胺衍生物、其制法与医药上的用途
JP6913032B2 (ja) 2015-05-20 2021-08-04 ザ・ブロード・インスティテュート・インコーポレイテッド 共通ネオ抗原
SG10202008909VA (en) 2016-03-24 2020-10-29 Bayer Pharma AG Prodrugs of cytotoxic active agents having enzymatically cleavable groups
US11821042B2 (en) 2017-07-10 2023-11-21 Cornell University Targeting chromosomal instability and downstream cytosolic DNA signaling for cancer treatment
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES
CN108768023B (zh) 2018-08-13 2020-01-07 珠海格力电器股份有限公司 转子组件及交替极电机
DE102018213662A1 (de) 2018-08-14 2020-02-20 Robert Bosch Gmbh Lautsprecher mit einem darin enthaltenen Leuchtelement
CN109039072B (zh) 2018-08-21 2020-09-08 南京南瑞继保电气有限公司 一种双极双向直流变换器及其控制方法和控制装置
MA54550A (fr) * 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
IL283639B2 (en) 2018-12-20 2024-06-01 Amgen Inc Kif18a inhibitors
AU2019404576B2 (en) 2018-12-20 2025-07-17 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
EP3946470A4 (en) 2019-04-05 2023-05-31 Earli Inc. IMPROVED METHODS AND COMPOSITIONS FOR SYNTHETIC BIOMARKERS
KR102449386B1 (ko) 2019-05-03 2022-10-05 주식회사 디시젠 암 예후 예측방법 및 이의 조성물
US20230093080A1 (en) 2019-07-15 2023-03-23 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US20220289724A1 (en) 2019-08-02 2022-09-15 Amgen Inc. Kif18a inhibitors
MX428368B (es) 2019-08-02 2025-11-13 Amgen Inc Inhibidores de kif18a
JP7699100B2 (ja) 2019-08-02 2025-06-26 アムジエン・インコーポレーテツド Kif18a阻害剤
AU2020325115B2 (en) * 2019-08-02 2026-03-12 Amgen Inc. Pyridine derivatives as KIF18A inhibitors
EP4103045A4 (en) 2020-02-16 2024-08-14 Genetikaplus Ltd. Methods of therapeutic prognostication
US12187992B2 (en) 2020-02-19 2025-01-07 The Regents Of The University Of California Method and device for early cancer screening
JP2023521802A (ja) 2020-04-14 2023-05-25 アムジエン・インコーポレーテツド 新生物疾患の処置のためのkif18a阻害剤
WO2021231413A1 (en) 2020-05-11 2021-11-18 University Of Vermont A treatment approach involving kif18a inhibition for chromosomally unstable tumors
TW202220958A (zh) 2020-08-07 2022-06-01 美商卡司馬療法公司 Trpml調節劑
EP4319821A4 (en) 2021-04-09 2026-05-06 Nanjing University CONJUGATE AND ITS PREPARATION PROCESS AND ITS USE
CN113528509A (zh) 2021-06-01 2021-10-22 释科生物科技(广州)有限公司 一种用于预测胃癌免疫治疗的肿瘤微环境评分系统的构建方法以及分子探针
EP4361142A4 (en) 2021-06-25 2025-07-09 Hangzhou Innogate Pharma Co Ltd COMPOUND FOR USE AS A KIF18A INHIBITOR
TW202321213A (zh) 2021-07-21 2023-06-01 美商安進公司 Kif18a抑制劑化合物之鹽和固態形式
CN115772159A (zh) 2021-09-06 2023-03-10 微境生物医药科技(上海)有限公司 Kif18a抑制剂
CN115785068A (zh) 2021-09-10 2023-03-14 微境生物医药科技(上海)有限公司 Kif18a抑制剂
CN118076586A (zh) 2021-09-16 2024-05-24 微境生物医药科技(上海)有限公司 Kif18a抑制剂
US20230117405A1 (en) 2021-09-22 2023-04-20 Volastra Therapeutics, Inc. Systems and methods for evaluation of chromosomal instability using machine-learning
MX2024005996A (es) 2021-11-19 2024-05-30 Wigen Biomedicine Tech Shanghai Co Ltd Inhibidor de kif18a.
AU2023261964A1 (en) 2022-04-28 2024-11-07 Volastra Therapeutics, Inc. Compounds for inhibiting kif18a

Similar Documents

Publication Publication Date Title
CN108366996B (zh) 四氢-1H-吡啶[3,4-b]吲哚类抗雌激素药物
JP6530313B2 (ja) ヒストン脱メチル化酵素の阻害剤
JP6514117B2 (ja) ヒストン脱メチル化酵素の阻害剤
JP6824954B2 (ja) mIDH1阻害剤としての5−ヒドロキシアルキルベンズイミダゾール
US10676438B2 (en) KCNQ2-5 channel activator
JP6950534B2 (ja) テトラヒドロナフタレン誘導体
JP2025515484A5 (enExample)
JP2020063289A5 (enExample)
TW202114985A (zh) Ep拮抗劑
JP2025506206A5 (enExample)
CN115916750A (zh) 用于制备具有经取代的苯基或吡啶基部分的serd三环化合物的方法
JPH11512422A (ja) ベンゾチアゾロン誘導体
JP2010517952A (ja) 5−ht7受容体リガンドとしての複素環置換テトラヒドロナフタレン誘導体
TWI874960B (zh) 聯芳組成物和調控激酶級聯之方法
JP2007507473A5 (enExample)
WO2002030872A1 (en) Novel aliphatic compounds, process for their preparation and their usage
JP7716980B2 (ja) エストロゲン受容体拮抗剤
JP2004359546A (ja) ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および/または治療剤
US9271979B2 (en) Deuterium-enriched pyrimidine compounds and derivatives
JP2015137266A (ja) インドール誘導体、またはその薬理学的に許容される塩
WO2013064029A1 (zh) 具有抗癌活性的苯甲酰脲衍生物及其制备方法和用途
JPH07179344A (ja) 抗片頭痛性トリプタミンシクロブテンジオン誘導体
TW202241398A (zh) 含有ep2拮抗劑之醫藥組成物
US10106560B2 (en) Process and intermediates for making tubulysin analogs
WO2025255470A1 (en) Compounds and uses thereof