|
US5422251A
(en)
|
1986-11-26 |
1995-06-06 |
Princeton University |
Triple-stranded nucleic acids
|
|
US5674722A
(en)
|
1987-12-11 |
1997-10-07 |
Somatix Therapy Corporation |
Genetic modification of endothelial cells
|
|
US5176996A
(en)
|
1988-12-20 |
1993-01-05 |
Baylor College Of Medicine |
Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
|
|
US5420032A
(en)
|
1991-12-23 |
1995-05-30 |
Universitge Laval |
Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
|
|
US5792632A
(en)
|
1992-05-05 |
1998-08-11 |
Institut Pasteur |
Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
|
|
GB9526131D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Recombinant chimeric receptors
|
|
GB9807935D0
(en)
|
1998-04-14 |
1998-06-10 |
Univ Edinburgh |
Lineage specific cells and progenitor cells
|
|
EP0931158A1
(en)
|
1996-09-06 |
1999-07-28 |
The Trustees Of The University Of Pennsylvania |
An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
|
|
US7541034B1
(en)
|
1997-03-20 |
2009-06-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors
|
|
US6361996B1
(en)
|
1997-05-07 |
2002-03-26 |
University Of Utah Research Foundation |
Neuroepithelial stem cells and glial-restricted intermediate precursors
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6136597A
(en)
|
1997-09-18 |
2000-10-24 |
The Salk Institute For Biological Studies |
RNA export element
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US8263402B1
(en)
|
1998-10-19 |
2012-09-11 |
Cornell Research Foundation, Inc. |
Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
|
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
AU776576B2
(en)
|
1999-12-06 |
2004-09-16 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
US6689558B2
(en)
|
2000-02-08 |
2004-02-10 |
Sangamo Biosciences, Inc. |
Cells for drug discovery
|
|
US8273570B2
(en)
|
2000-05-16 |
2012-09-25 |
Riken |
Process of inducing differentiation of embryonic cell to cell expressing neural surface marker using OP9 or PA6 cells
|
|
JP2002060786A
(ja)
|
2000-08-23 |
2002-02-26 |
Kao Corp |
硬質表面用殺菌防汚剤
|
|
US7067317B2
(en)
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
JP2005500061A
(ja)
|
2001-08-20 |
2005-01-06 |
ザ スクリップス リサーチ インスティテュート |
Ｃｎｎについての亜鉛フィンガー結合ドメイン
|
|
US7355012B2
(en)
|
2001-09-26 |
2008-04-08 |
United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-CD22 antibodies with increased affinity to CD22-expressing leukemia cells
|
|
US7262054B2
(en)
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
WO2003070171A2
(en)
|
2002-02-15 |
2003-08-28 |
Cornell Research Foundation, Inc. |
Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
|
|
US20050101014A1
(en)
|
2002-07-11 |
2005-05-12 |
Keirstead Hans S. |
Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
|
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
|
BRPI0408733A
(pt)
|
2003-03-12 |
2006-03-07 |
Reliance Life Sciences Pvt Ltd |
derivação de neurÈnios dopaminérgicos terminalmente diferenciados de células tronco embriÈnicas humanas
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US7982011B2
(en)
|
2003-11-25 |
2011-07-19 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-cd22 antibodies and immunoconjugates
|
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US7452718B2
(en)
|
2004-03-26 |
2008-11-18 |
Geron Corporation |
Direct differentiation method for making cardiomyocytes from human embryonic stem cells
|
|
AU2005232665B2
(en)
|
2004-04-08 |
2010-05-13 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating neuropathic and neurodegenerative conditions
|
|
US7253273B2
(en)
|
2004-04-08 |
2007-08-07 |
Sangamo Biosciences, Inc. |
Treatment of neuropathic pain with zinc finger proteins
|
|
JP5560393B2
(ja)
|
2005-06-22 |
2014-07-23 |
アステリアス バイオセラピューティクス インコーポレイテッド |
心筋細胞系列細胞への霊長類多能性幹細胞の分化
|
|
ES2582091T3
(es)
|
2005-10-18 |
2016-09-09 |
Precision Biosciences |
Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
|
|
EP2028268A1
(en)
|
2007-08-20 |
2009-02-25 |
Université Libre De Bruxelles |
Generation of neuronal cells from pluripotent stem cells
|
|
WO2009057111A2
(en)
|
2007-10-29 |
2009-05-07 |
Hadasit Medical Research Services & Development Limited |
Human stem cell-derived neural precursors for treatment of autoimmune diseases of the central nervous system
|
|
US8227247B2
(en)
|
2007-12-20 |
2012-07-24 |
Wisconsin Alumni Research Foundation |
Method of generating myelinating oligodendrocytes
|
|
US8728812B2
(en)
|
2008-04-22 |
2014-05-20 |
President And Fellows Of Harvard College |
Compositions and methods for promoting the generation of PDX1+ pancreatic cells
|
|
KR20110011658A
(ko)
|
2008-05-08 |
2011-02-08 |
유니버시티 오브 로체스터 |
최적화된 세포 제제에 의한 수초 질환의 치료
|
|
US8669048B2
(en)
|
2008-06-24 |
2014-03-11 |
Parkinson's Institute |
Pluripotent cell lines and methods of use thereof
|
|
WO2010022395A2
(en)
|
2008-08-22 |
2010-02-25 |
President And Fellows Of Harvard College |
Methods of reprogramming cells
|
|
EP3187581A1
(en)
|
2008-12-23 |
2017-07-05 |
BOCO Silicon Valley, Inc. |
Target populations of oligodendrocyte precursor cells and methods of making and using same
|
|
US8507274B2
(en)
|
2009-02-06 |
2013-08-13 |
President And Fellows Of Harvard College |
Compositions and methods for promoting the generation of definitive endoderm
|
|
MX341884B
(es)
|
2009-03-10 |
2016-09-07 |
Biogen Ma Inc |
Anticuerpos anti-antigeno de maduracion de celulas b (bcma).
|
|
WO2010144696A1
(en)
|
2009-06-11 |
2010-12-16 |
Burnham Institute For Medical Research |
Directed differentiation of stem cells
|
|
CA2778931A1
(en)
|
2009-06-12 |
2010-12-16 |
Marianne Allard |
Guanine riboswitch binding compounds and their use as antibiotics
|
|
US8586526B2
(en)
|
2010-05-17 |
2013-11-19 |
Sangamo Biosciences, Inc. |
DNA-binding proteins and uses thereof
|
|
WO2011091048A1
(en)
|
2010-01-19 |
2011-07-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Direct conversion of cells to cells of other lineages
|
|
WO2011130675A2
(en)
|
2010-04-16 |
2011-10-20 |
The Mclean Hospital Corporation |
Dopaminergic neurons differentiated from pluripotent stem cells and uses of thereof
|
|
WO2011159726A2
(en)
|
2010-06-14 |
2011-12-22 |
The Scripps Research Institute |
Reprogramming of cells to a new fate
|
|
SG189269A1
(en)
|
2010-10-26 |
2013-05-31 |
Univ Case Western Reserve |
Differentiation methods for production of glial cell populations
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
WO2012135253A1
(en)
|
2011-03-29 |
2012-10-04 |
Geron Corporation |
Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
|
|
DK2694644T3
(en)
|
2011-03-30 |
2018-04-16 |
Cellular Dynamics Int Inc |
Priming of pluripotent stem cells for neural differentiation
|
|
KR101972446B1
(ko)
|
2011-05-27 |
2019-04-25 |
글락소 그룹 리미티드 |
Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）결합 단백질
|
|
CN111500665A
(zh)
|
2011-07-21 |
2020-08-07 |
小利兰·斯坦福大学托管委员会 |
来自患者的诱导性多能干细胞的心肌细胞及其使用方法
|
|
CN103946952A
(zh)
|
2011-09-16 |
2014-07-23 |
宾夕法尼亚大学董事会 |
用于治疗癌症的rna改造的t细胞
|
|
US8951798B2
(en)
|
2011-10-13 |
2015-02-10 |
Wisconsin Alumni Research Foundation |
Generation of cardiomyocytes from human pluripotent stem cells
|
|
US9850463B2
(en)
|
2012-02-01 |
2017-12-26 |
The Regents Of The University Of California |
Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation
|
|
WO2013130824A1
(en)
|
2012-02-29 |
2013-09-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
|
US9458428B2
(en)
|
2012-06-05 |
2016-10-04 |
The Regents Of The University Of California |
Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
|
|
JP6541577B2
(ja)
|
2013-02-06 |
2019-07-10 |
ユニバーシティー オブ ロチェスター |
ミエリン障害の治療のための誘導多能性細胞由来オリゴデンドロサイト前駆細胞
|
|
EP3498824A1
(en)
|
2013-04-26 |
2019-06-19 |
Memorial Sloan-Kettering Cancer Center |
Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US10421989B2
(en)
|
2014-02-26 |
2019-09-24 |
Cornell University |
Methods and reagents for riboswitch analysis
|
|
PL3145517T3
(pl)
|
2014-05-22 |
2021-04-06 |
New York Stem Cell Foundation, Inc. |
Funkcjonalne oligodendrocyty pochodzące z pluripotencjalnych komórek macierzystych oraz sposoby ich otrzymywania i stosowania
|
|
JP6651218B2
(ja)
|
2014-05-30 |
2020-02-19 |
国立大学法人京都大学 |
低分子化合物を用いた多能性幹細胞の心筋分化誘導法
|
|
EP2990416B1
(en)
|
2014-08-29 |
2018-06-20 |
GEMoaB Monoclonals GmbH |
Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
|
|
US9765299B2
(en)
|
2014-09-10 |
2017-09-19 |
Wisconsin Alumni Research Foundation |
Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
|
|
WO2016126608A1
(en)
|
2015-02-02 |
2016-08-11 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
|
US10738116B2
(en)
|
2015-03-19 |
2020-08-11 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Dual specific anti-CD22-anti-CD19 chimeric antigen receptors
|
|
AU2016243583B2
(en)
|
2015-03-27 |
2022-03-10 |
President And Fellows Of Harvard College |
Modified T cells and methods of making and using the same
|
|
US9724432B2
(en)
|
2015-04-30 |
2017-08-08 |
University Of Rochester |
Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
|
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
|
WO2018028647A1
(en)
|
2016-08-10 |
2018-02-15 |
Legend Biotech Usa Inc. |
Chimeric antigen receptors targeting bcma and methods of use thereof
|
|
HK1256610A1
(zh)
|
2015-08-15 |
2019-09-27 |
阿斯特利亚斯生物治疗股份公司 |
用於治疗白质中风的干细胞衍生的少突胶质细胞祖细胞
|
|
JP2018534264A
(ja)
|
2015-09-28 |
2018-11-22 |
リージェンツ オブ ザ ユニバーシティ オブ ミネソタ |
自己免疫および同種免疫への治療的介入としてのキメラ抗原受容体（ｃａｒ）ｔ細胞
|
|
US20180291080A1
(en)
|
2015-09-28 |
2018-10-11 |
Trustees Of Dartmouth College |
Chimeric antigen receptor, regulatory cells and methods of use
|
|
KR102904879B1
(ko)
|
2015-11-12 |
2025-12-30 |
베이롤 칼리지 오브 메드신 |
폴리아데닐화의 압타머 매개된 조정을 통한 포유류 유전자 발현의 외인성 제어
|
|
JP7235507B2
(ja)
|
2016-03-03 |
2023-03-08 |
ニューヨーク ステム セル ファウンデーション インコーポレイテッド |
多能性幹細胞由来のミクログリアならびにその作製および使用方法
|
|
WO2017172976A1
(en)
|
2016-03-29 |
2017-10-05 |
The Regents Of The University Of California |
Methods for promoting oligodendrocyte regeneration and remyelination
|
|
WO2018093681A1
(en)
|
2016-11-15 |
2018-05-24 |
Neuralstem, Inc. |
Multipotent neural stem cells that express platelet derived growth factor (pdgf) receptor and methods of use thereof
|
|
JP2020505025A
(ja)
|
2017-01-13 |
2020-02-20 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
免疫工学的な改変をした多能性細胞
|
|
WO2018176390A1
(zh)
|
2017-03-31 |
2018-10-04 |
深圳市立昌机电设备有限公司 |
绕线机的安全防备方法及系统
|
|
WO2018191490A1
(en)
|
2017-04-13 |
2018-10-18 |
The Trustees Of The University Of Pennsylvania |
Use of gene editing to generate universal tcr re-directed t cells for adoptive immunotherapy
|
|
CN110650975B
(zh)
|
2017-05-15 |
2024-04-05 |
美国卫生和人力服务部 |
双顺反子嵌合抗原受体及其用途
|
|
ES2928296T3
(es)
|
2017-06-30 |
2022-11-16 |
Us Health |
Receptores de antígenos quiméricos anti-antígenos de maduración de linfocitos B con dominios humanos
|
|
US11807663B2
(en)
|
2018-02-01 |
2023-11-07 |
Innovent Biologics (Suzhou) Co., Ltd. |
Fully humanized anti-B cell maturation antigen (BCMA) single-chain antibody and use thereof
|
|
PT3674328T
(pt)
|
2018-02-01 |
2024-03-14 |
Innovent Biologics Suzhou Co Ltd |
Recetor de antigénio quimérico (car) que se liga a bcma e utilizações do mesmo
|
|
EP3674327A4
(en)
|
2018-02-01 |
2021-05-05 |
Nanjing Iaso Biotherapeutics Co., Ltd. |
BINDING OF CHIMERIC ANTIGEN RECEPTOR (CAR) TO BCMA AND USES THEREOF
|
|
US11939377B2
(en)
|
2018-07-12 |
2024-03-26 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Affinity matured CD22-specific monoclonal antibody and uses thereof
|
|
WO2020018620A1
(en)
|
2018-07-17 |
2020-01-23 |
The Regents Of The University Of California |
Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells
|
|
CA3109078A1
(en)
|
2018-07-17 |
2020-01-23 |
The Regents Of The University Of California |
Cells differentiated from immunoengineered pluripotent cells
|
|
KR20210128440A
(ko)
|
2019-02-15 |
2021-10-26 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
범용 공여자 줄기 세포 및 관련 방법
|
|
US20220267732A1
(en)
|
2019-08-01 |
2022-08-25 |
Sana Biotechnology, Inc. |
Dux4 expressing cells and uses thereof
|
|
JP7728747B2
(ja)
|
2019-08-23 |
2025-08-25 |
サナ バイオテクノロジー，インコーポレイテッド |
Ｃｄ２４発現細胞およびそれらの用途
|
|
CN115279902A
(zh)
|
2019-08-30 |
2022-11-01 |
贝勒医学院 |
用于调控基因表达的系统
|
|
AU2021262766A1
(en)
|
2020-04-27 |
2022-11-24 |
Sana Biotechnology, Inc. |
Repeat dosing of hypoimmunogenic cells
|