JP2024531064A - ジアリールイソオキサゾリン誘導体を作製するための方法 - Google Patents

ジアリールイソオキサゾリン誘導体を作製するための方法 Download PDF

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Publication number
JP2024531064A
JP2024531064A JP2024503432A JP2024503432A JP2024531064A JP 2024531064 A JP2024531064 A JP 2024531064A JP 2024503432 A JP2024503432 A JP 2024503432A JP 2024503432 A JP2024503432 A JP 2024503432A JP 2024531064 A JP2024531064 A JP 2024531064A
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formula
compound
methyl
alkyl
clause
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JP2024503432A
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Japanese (ja)
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JP2024531064A5 (enExample
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フ，ジンダン
ウ，グアンミン
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Elanco US Inc
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Elanco US Inc
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Publication of JP2024531064A publication Critical patent/JP2024531064A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024503432A 2021-08-11 2022-08-10 ジアリールイソオキサゾリン誘導体を作製するための方法 Pending JP2024531064A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163231858P 2021-08-11 2021-08-11
US63/231,858 2021-08-11
US202263306240P 2022-02-03 2022-02-03
US63/306,240 2022-02-03
PCT/US2022/039965 WO2023018806A1 (en) 2021-08-11 2022-08-10 Process for making diaryl isoxazoline derivative

Publications (2)

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JP2024531064A true JP2024531064A (ja) 2024-08-29
JP2024531064A5 JP2024531064A5 (enExample) 2025-08-18

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JP2024503432A Pending JP2024531064A (ja) 2021-08-11 2022-08-10 ジアリールイソオキサゾリン誘導体を作製するための方法

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US (1) US20240308993A1 (enExample)
EP (1) EP4384514A1 (enExample)
JP (1) JP2024531064A (enExample)
KR (1) KR20240046112A (enExample)
AU (1) AU2022326468A1 (enExample)
BR (1) BR112023026362A2 (enExample)
CA (1) CA3224701A1 (enExample)
MX (1) MX2023014962A (enExample)
TW (1) TW202312880A (enExample)
WO (1) WO2023018806A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12655138B2 (en) 2020-07-24 2026-06-16 Elanco Us Inc. Process for making an isoxazoline compound and intermediate thereof
NO20240925A1 (en) 2023-09-15 2025-03-17 Evah Atlantic Inc Dihydroisoxazole compound for use in reducing ectoparasite infestations on fish
CN117486869A (zh) * 2023-11-06 2024-02-02 北京康立生医药技术开发有限公司 一种眼科治疗药物新的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009063910A1 (ja) * 2007-11-12 2009-05-22 Nissan Chemical Industries, Ltd. 光学活性イソキサゾリン化合物の触媒的不斉合成方法
JP2014505089A (ja) * 2011-02-10 2014-02-27 ノバルティス アーゲー 無脊椎有害動物を防除するためのイソオキサゾリン誘導体
WO2014090918A1 (en) * 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
WO2016077158A1 (en) * 2014-11-10 2016-05-19 Novartis Tiergesundheit Ag Diaryl isoxazoline compound
WO2017176948A1 (en) * 2016-04-06 2017-10-12 Merial, Inc. Process for the preparation of enantiomerically enriched isoxazoline compounds - crystalline toluene solvate of (s)-afoxolaner
WO2017196607A1 (en) * 2016-05-10 2017-11-16 Elanco Tiergesundheit Ag Dihydroisoxazole compound for use in controlling sea lice

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR074790A1 (es) 2008-12-19 2011-02-09 Novartis Ag Derivados de isooxazol sustituidos, composiciones farmaceuticas y para el control de parasitos que los comprenden y su uso en metodos para controlar parasitos en y sobre animales de sangre caliente.
US20140206633A1 (en) 2010-02-25 2014-07-24 Syngenta Crop Protection Llc Process for the preparation of isoxazoline derivatives
JP6075563B2 (ja) 2011-11-08 2017-02-08 日産化学工業株式会社 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物
US20140343085A1 (en) 2011-11-29 2014-11-20 Novartis Ag Use of aryl derivatives for controlling ectoparasites
CN104169276A (zh) 2012-02-03 2014-11-26 佐蒂斯有限责任公司 作为抗寄生物剂的手性异噁唑啉氮杂环丁烷衍生物的制备方法
EP2922854B1 (en) 2012-11-21 2022-05-04 Zoetis Services LLC Synthesis of spirocyclic isoxazoline derivatives

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009063910A1 (ja) * 2007-11-12 2009-05-22 Nissan Chemical Industries, Ltd. 光学活性イソキサゾリン化合物の触媒的不斉合成方法
JP2014505089A (ja) * 2011-02-10 2014-02-27 ノバルティス アーゲー 無脊椎有害動物を防除するためのイソオキサゾリン誘導体
WO2014090918A1 (en) * 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
WO2016077158A1 (en) * 2014-11-10 2016-05-19 Novartis Tiergesundheit Ag Diaryl isoxazoline compound
WO2017176948A1 (en) * 2016-04-06 2017-10-12 Merial, Inc. Process for the preparation of enantiomerically enriched isoxazoline compounds - crystalline toluene solvate of (s)-afoxolaner
WO2017196607A1 (en) * 2016-05-10 2017-11-16 Elanco Tiergesundheit Ag Dihydroisoxazole compound for use in controlling sea lice

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAZUTAKA MATOBA, ET AL.: "Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines: Asymmetric Hydroxylamine/E", ANGEW. CHEM. INT. ED., vol. 49(33), JPN6026014025, 2010, pages 5762 - 5766, ISSN: 0005839402 *

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Publication number Publication date
TW202312880A (zh) 2023-04-01
MX2023014962A (es) 2024-02-13
BR112023026362A2 (pt) 2024-03-05
KR20240046112A (ko) 2024-04-08
EP4384514A1 (en) 2024-06-19
WO2023018806A1 (en) 2023-02-16
AU2022326468A1 (en) 2023-11-30
CA3224701A1 (en) 2023-02-16
US20240308993A1 (en) 2024-09-19

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