JP2024530487A5 - - Google Patents
Info
- Publication number
- JP2024530487A5 JP2024530487A5 JP2024507108A JP2024507108A JP2024530487A5 JP 2024530487 A5 JP2024530487 A5 JP 2024530487A5 JP 2024507108 A JP2024507108 A JP 2024507108A JP 2024507108 A JP2024507108 A JP 2024507108A JP 2024530487 A5 JP2024530487 A5 JP 2024530487A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- prime editor
- reverse transcriptase
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163230688P | 2021-08-06 | 2021-08-06 | |
| US63/230,688 | 2021-08-06 | ||
| US202263388888P | 2022-07-13 | 2022-07-13 | |
| US63/388,888 | 2022-07-13 | ||
| PCT/US2022/074628 WO2023015309A2 (en) | 2021-08-06 | 2022-08-05 | Improved prime editors and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024530487A JP2024530487A (ja) | 2024-08-21 |
| JP2024530487A5 true JP2024530487A5 (enExample) | 2025-08-20 |
Family
ID=83188605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024507108A Pending JP2024530487A (ja) | 2021-08-06 | 2022-08-05 | 改善されたプライムエディターおよび使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250270593A1 (enExample) |
| EP (1) | EP4381057A2 (enExample) |
| JP (1) | JP2024530487A (enExample) |
| AU (1) | AU2022325166A1 (enExample) |
| CA (1) | CA3227004A1 (enExample) |
| WO (1) | WO2023015309A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| KR20260037664A (ko) | 2021-09-08 | 2026-03-18 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈을 조절하기 위한 방법 및 조성물 |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
| CN117511906A (zh) * | 2023-03-14 | 2024-02-06 | 中国农业大学 | 一种高效的Csy4核酸酶切割介导的多基因引导编辑系统CMPE及相关蛋白 |
| WO2024240138A1 (zh) * | 2023-05-22 | 2024-11-28 | 江西农业大学 | 基于perv逆转录酶的先导编辑系统 |
| KR20260028193A (ko) | 2023-05-23 | 2026-03-03 | 더 브로드 인스티튜트, 인코퍼레이티드 | 개선된 에디팅 효율을 갖는 진화 및 조작된 프라임 에디터 |
| WO2025022290A1 (en) | 2023-07-21 | 2025-01-30 | Crispr Therapeutics Ag | Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene |
| KR20260062936A (ko) * | 2023-08-29 | 2026-05-07 | 성균관대학교산학협력단 | Eys 유전자 교정 프라임 에디터 및 그 용도 |
| WO2025096936A2 (en) | 2023-11-03 | 2025-05-08 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cdkl5 |
| WO2025151814A1 (en) | 2024-01-10 | 2025-07-17 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cftr |
| WO2025217616A1 (en) | 2024-04-12 | 2025-10-16 | The Broad Institute, Inc. | Prime editing and base editing of the atp1a3 gene for the treatment of alternating hemiplegia of childhood |
| WO2026015832A2 (en) * | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| WO2026015829A2 (en) * | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| WO2026055354A2 (en) * | 2024-09-04 | 2026-03-12 | University Of Massachusetts | Prime editing with modification-tolerant polymerases |
| WO2026069163A1 (en) | 2024-09-25 | 2026-04-02 | Crispr Therapeutics Ag | Differentiation method for producing immature beta cells |
| WO2026106945A2 (en) | 2024-11-12 | 2026-05-21 | The Broad Institute, Inc. | Engineered prime editing guide rnas and methods of making and using same |
| CN120536504B (zh) * | 2025-07-29 | 2026-01-06 | 江西农业大学 | 基于内源性多基因编辑的阿尔茨海默病模型猪的构建方法 |
| CN121768486A (zh) * | 2026-03-02 | 2026-03-31 | 湘湖实验室(农业浙江省实验室) | 一种基于深度特征与自动化机器学习的sgRNA活性预测方法及装置 |
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| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
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| EP3199630B1 (en) | 2008-09-05 | 2019-05-08 | President and Fellows of Harvard College | Continuous directed evolution of proteins and nucleic acids |
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| PT2877490T (pt) | 2012-06-27 | 2019-02-12 | Univ Princeton | Inteínas clivadas, conjugados e suas utilizações |
| US10047352B2 (en) | 2012-10-03 | 2018-08-14 | Agrivida, Inc. | Intein-modified proteases, their production and industrial applications |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| EP3097196B1 (en) | 2014-01-20 | 2019-09-11 | President and Fellows of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| DK3212778T3 (da) | 2014-10-28 | 2019-11-04 | Agrivida Inc | Fremgangsmåder og sammensætninger til stabilisering af trans-splejsning af intein-modificerede proteaser |
| US11299729B2 (en) | 2015-04-17 | 2022-04-12 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| US9580698B1 (en) | 2016-09-23 | 2017-02-28 | New England Biolabs, Inc. | Mutant reverse transcriptase |
| EP3610006B1 (en) * | 2017-04-11 | 2021-05-19 | Roche Diagnostics GmbH | Mutant reverse transcriptase with increased thermal stability as well as products, methods and uses involving the same |
| US20200140835A1 (en) * | 2017-06-06 | 2020-05-07 | The General Hospital Corporation | Engineered CRISPR-Cas9 Nucleases |
| EP3707252A1 (en) * | 2017-11-10 | 2020-09-16 | Novozymes A/S | Temperature-sensitive cas9 protein |
| WO2020191241A1 (en) * | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2021080922A1 (en) * | 2019-10-21 | 2021-04-29 | The Trustees Of Columbia University In The City Of New York | Methods of performing rna templated genome editing |
| JP7785002B2 (ja) * | 2019-11-05 | 2025-12-12 | ペアーワイズ プランツ サービシズ， インコーポレイテッド | 対立遺伝子のｒｎａにコードされたｄｎａの置換のための組成物および方法 |
| BR112022017715A2 (pt) * | 2020-03-04 | 2022-11-16 | Flagship Pioneering Innovations Vi Llc | Métodos e composições para modular um genoma |
-
2022
- 2022-08-05 AU AU2022325166A patent/AU2022325166A1/en active Pending
- 2022-08-05 JP JP2024507108A patent/JP2024530487A/ja active Pending
- 2022-08-05 WO PCT/US2022/074628 patent/WO2023015309A2/en not_active Ceased
- 2022-08-05 CA CA3227004A patent/CA3227004A1/en active Pending
- 2022-08-05 EP EP22764605.6A patent/EP4381057A2/en active Pending
- 2022-08-05 US US18/681,490 patent/US20250270593A1/en active Pending
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