JP2024530487A5 - - Google Patents
Info
- Publication number
- JP2024530487A5 JP2024530487A5 JP2024507108A JP2024507108A JP2024530487A5 JP 2024530487 A5 JP2024530487 A5 JP 2024530487A5 JP 2024507108 A JP2024507108 A JP 2024507108A JP 2024507108 A JP2024507108 A JP 2024507108A JP 2024530487 A5 JP2024530487 A5 JP 2024530487A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- prime editor
- reverse transcriptase
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163230688P | 2021-08-06 | 2021-08-06 | |
| US63/230,688 | 2021-08-06 | ||
| US202263388888P | 2022-07-13 | 2022-07-13 | |
| US63/388,888 | 2022-07-13 | ||
| PCT/US2022/074628 WO2023015309A2 (en) | 2021-08-06 | 2022-08-05 | Improved prime editors and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024530487A JP2024530487A (ja) | 2024-08-21 |
| JP2024530487A5 true JP2024530487A5 (enExample) | 2025-08-20 |
Family
ID=83188605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024507108A Pending JP2024530487A (ja) | 2021-08-06 | 2022-08-05 | 改善されたプライムエディターおよび使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250270593A1 (enExample) |
| EP (1) | EP4381057A2 (enExample) |
| JP (1) | JP2024530487A (enExample) |
| AU (1) | AU2022325166A1 (enExample) |
| CA (1) | CA3227004A1 (enExample) |
| WO (1) | WO2023015309A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| AU2022343268A1 (en) | 2021-09-08 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods and compositions for modulating a genome |
| CA3231712A1 (en) | 2021-09-08 | 2023-03-16 | Flagship Pioneering Innovations Vi, Llc | Pah-modulating compositions and methods |
| WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
| WO2024240138A1 (zh) * | 2023-05-22 | 2024-11-28 | 江西农业大学 | 基于perv逆转录酶的先导编辑系统 |
| WO2024243415A1 (en) | 2023-05-23 | 2024-11-28 | The Broad Institute, Inc. | Evolved and engineered prime editors with improved editing efficiency |
| AU2024301706A1 (en) | 2023-07-21 | 2026-02-05 | Crispr Therapeutics Ag | Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene |
| WO2025048436A1 (ko) * | 2023-08-29 | 2025-03-06 | 성균관대학교산학협력단 | Eys 유전자 교정 프라임 에디터 및 그 용도 |
| WO2025096936A2 (en) | 2023-11-03 | 2025-05-08 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cdkl5 |
| WO2025151814A1 (en) | 2024-01-10 | 2025-07-17 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cftr |
| WO2025217616A1 (en) | 2024-04-12 | 2025-10-16 | The Broad Institute, Inc. | Prime editing and base editing of the atp1a3 gene for the treatment of alternating hemiplegia of childhood |
| WO2026015829A2 (en) * | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Small reverse transcriptases and gene editing systems comprising such |
| WO2026015832A2 (en) * | 2024-07-12 | 2026-01-15 | Arbor Biotechnologies, Inc. | Reverse transcriptases and gene editing systems comprising such |
| WO2026069163A1 (en) | 2024-09-25 | 2026-04-02 | Crispr Therapeutics Ag | Differentiation method for producing immature beta cells |
| CN120536504B (zh) * | 2025-07-29 | 2026-01-06 | 江西农业大学 | 基于内源性多基因编辑的阿尔茨海默病模型猪的构建方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5049386A (en) | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5244797B1 (en) | 1988-01-13 | 1998-08-25 | Life Technologies Inc | Cloned genes encoding reverse transcriptase lacking rnase h activity |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| EP1235914A2 (en) | 1999-11-24 | 2002-09-04 | Joseph Rosenecker | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| US8178291B2 (en) | 2005-02-18 | 2012-05-15 | Monogram Biosciences, Inc. | Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors |
| US9783791B2 (en) | 2005-08-10 | 2017-10-10 | Agilent Technologies, Inc. | Mutant reverse transcriptase and methods of use |
| CN101668848B (zh) | 2007-04-26 | 2014-10-22 | 雷蒙特亚特特拉维夫大学有限公司 | 来自口腔粘膜的多能自体干细胞和使用方法 |
| WO2010028347A2 (en) | 2008-09-05 | 2010-03-11 | President & Fellows Of Harvard College | Continuous directed evolution of proteins and nucleic acids |
| US10113156B2 (en) | 2009-03-04 | 2018-10-30 | Board Of Regents, The University Of Texas System | Stabilized reverse transcriptase fusion proteins |
| US8889394B2 (en) | 2009-09-07 | 2014-11-18 | Empire Technology Development Llc | Multiple domain proteins |
| WO2012054727A1 (en) | 2010-10-22 | 2012-04-26 | Bio-Rad Laboratories, Inc. | Reverse transcriptase mixtures with improved storage stability |
| CA2825370A1 (en) | 2010-12-22 | 2012-06-28 | President And Fellows Of Harvard College | Continuous directed evolution |
| KR102096534B1 (ko) | 2011-09-28 | 2020-04-03 | 에라 바이오테크, 에스.에이. | 분할된 인테인 및 그의 이용 |
| EP3431497B1 (en) | 2012-06-27 | 2022-07-27 | The Trustees of Princeton University | Split inteins, conjugates and uses thereof |
| DK2904101T3 (da) | 2012-10-03 | 2019-08-12 | Agrivida Inc | Intein-modificerede proteaser, fremstilling deraf og industrielle anvendelser |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| WO2015134121A2 (en) | 2014-01-20 | 2015-09-11 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| CN107075491B (zh) | 2014-10-28 | 2021-07-06 | 谷万达公司 | 用于稳定反式剪接的内含肽修饰的蛋白酶的方法和组合物 |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| US9580698B1 (en) | 2016-09-23 | 2017-02-28 | New England Biolabs, Inc. | Mutant reverse transcriptase |
| US20200140835A1 (en) * | 2017-06-06 | 2020-05-07 | The General Hospital Corporation | Engineered CRISPR-Cas9 Nucleases |
| EP3707252A1 (en) * | 2017-11-10 | 2020-09-16 | Novozymes A/S | Temperature-sensitive cas9 protein |
| WO2020191233A1 (en) * | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US20220411768A1 (en) * | 2019-10-21 | 2022-12-29 | The Trustees Of Columbia University In The City Of New York | Methods of performing rna templated genome editing |
| CN116209756A (zh) * | 2020-03-04 | 2023-06-02 | 旗舰先锋创新Vi有限责任公司 | 调控基因组的方法和组合物 |
-
2022
- 2022-08-05 JP JP2024507108A patent/JP2024530487A/ja active Pending
- 2022-08-05 CA CA3227004A patent/CA3227004A1/en active Pending
- 2022-08-05 US US18/681,490 patent/US20250270593A1/en active Pending
- 2022-08-05 WO PCT/US2022/074628 patent/WO2023015309A2/en not_active Ceased
- 2022-08-05 EP EP22764605.6A patent/EP4381057A2/en active Pending
- 2022-08-05 AU AU2022325166A patent/AU2022325166A1/en active Pending
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