JP2024527570A5 - - Google Patents
Info
- Publication number
- JP2024527570A5 JP2024527570A5 JP2024500319A JP2024500319A JP2024527570A5 JP 2024527570 A5 JP2024527570 A5 JP 2024527570A5 JP 2024500319 A JP2024500319 A JP 2024500319A JP 2024500319 A JP2024500319 A JP 2024500319A JP 2024527570 A5 JP2024527570 A5 JP 2024527570A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- membered
- pharmaceutically acceptable
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163219160P | 2021-07-07 | 2021-07-07 | |
| US63/219,160 | 2021-07-07 | ||
| US202263354017P | 2022-06-21 | 2022-06-21 | |
| US63/354,017 | 2022-06-21 | ||
| PCT/US2022/073522 WO2023283610A1 (en) | 2021-07-07 | 2022-07-07 | Compounds for targeting degradation of irak4 proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024527570A JP2024527570A (ja) | 2024-07-25 |
| JP2024527570A5 true JP2024527570A5 (cg-RX-API-DMAC10.html) | 2025-07-11 |
Family
ID=82748311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024500319A Pending JP2024527570A (ja) | 2021-07-07 | 2022-07-07 | Ｉｒａｋ４タンパク質の分解をターゲティングするための化合物 |
Country Status (14)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2021119159A1 (en) | 2019-12-10 | 2021-06-17 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| CA3161878A1 (en) | 2019-12-17 | 2021-06-24 | Matthew M. Weiss | Irak degraders and uses thereof |
| WO2023152349A1 (en) * | 2022-02-14 | 2023-08-17 | Astrazeneca Ab | Irak4 inhibitors |
| EP4428134A1 (en) * | 2023-03-10 | 2024-09-11 | Dark Blue Therapeutics Ltd | Protac degraders of mllt1 and/or mllt3 |
| EP4389747A1 (en) * | 2022-12-21 | 2024-06-26 | Dark Blue Therapeutics Ltd | Imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives as mllt1 and mllt3 inhibitors |
| EP4638447A1 (en) * | 2022-12-21 | 2025-10-29 | Dark Blue Therapeutics Ltd | Imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrazine derivatives as mllt1 and mllt3 inhibitors |
| EP4656640A4 (en) * | 2023-03-03 | 2026-08-19 | Shanghai Qilu Pharmaceutical Res And Development Centre Ltd | Iraq's Degradation Agent 4 and its Use |
| US20240374588A1 (en) * | 2023-04-07 | 2024-11-14 | Astrazeneca Ab | Irak4 protacs |
| KR20260005340A (ko) * | 2023-05-30 | 2026-01-09 | 상하이 후이룬 파마슈티컬 컴퍼니 리미티드 | 트리시클릭 화합물, 이의 제조 방법 및 적용 |
| EP4759807A1 (en) | 2023-08-11 | 2026-06-17 | Shenzhen Zhongge Biological Technology Co., Ltd. | Proteolysis targeting chimera compound for degrading irak4 and use thereof |
| EP4763839A1 (en) * | 2023-08-15 | 2026-06-24 | Pamplona Therapeutics (Shenzhen) Co., Ltd. | Compound targeting irak protein inhibition or degradation and use thereof |
| WO2025106480A1 (en) * | 2023-11-13 | 2025-05-22 | Regents Of The University Of Michigan | Compounds and compositions as smarca2/4 degraders and uses thereof |
| WO2025106472A1 (en) * | 2023-11-13 | 2025-05-22 | Regents Of The University Of Michigan | Compounds and compositions as smarca2/4 degraders and uses thereof |
| US20250197411A1 (en) * | 2023-12-14 | 2025-06-19 | Astrazeneca Ab | Irak4 protacs |
| WO2026035999A1 (en) | 2024-08-09 | 2026-02-12 | Triana Biomedicines, Inc. | Anaplastic lymphoma kinase (alk) degraders and uses thereof |
| CN119019427B (zh) * | 2024-08-14 | 2026-01-20 | 泰诺瑞(天津)生物科技有限责任公司 | 一种三并环类化合物及其应用 |
| US20260146050A1 (en) | 2024-11-27 | 2026-05-28 | Boehringer Ingelheim International Gmbh | Kras degrading compounds comprising spirocyclic annulated 2 amino-3-cyano thiophenes |
| WO2026139448A1 (en) | 2024-12-23 | 2026-07-02 | Merck Patent Gmbh | Heterobifunctional compounds for the degradation of kras protein |
| WO2026156134A1 (en) | 2025-01-17 | 2026-07-23 | F. Hoffmann-La Roche Ag | Tyk2 degraders |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| GB9208740D0 (en) | 1992-04-23 | 1992-06-10 | Glaxo Group Ltd | Chemical compounds |
| EP4649963A3 (en) | 2014-04-14 | 2026-05-13 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| JP6815318B2 (ja) | 2014-12-23 | 2021-01-20 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | 二官能性分子によって標的化タンパク質分解を誘導する方法 |
| JP6817962B2 (ja) | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
| AU2016232705C1 (en) | 2015-03-18 | 2021-06-17 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
| CA2988414C (en) | 2015-06-04 | 2023-09-26 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| EP3319944A4 (en) | 2015-07-10 | 2019-04-24 | Arvinas, Inc. | MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS |
| CA2988436A1 (en) | 2015-07-13 | 2017-01-19 | Arvinas, Inc. | Alanine-based modulators of proteolysis and associated methods of use |
| EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
| AU2017246452C1 (en) | 2016-04-06 | 2021-06-03 | The Regents Of The University Of Michigan | MDM2 protein degraders |
| AU2017250076B2 (en) | 2016-04-12 | 2021-07-22 | The Regents Of The University Of Michigan | Bet protein degraders |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| WO2017197056A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Bromodomain targeting degronimers for target protein degradation |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| EP3512842B1 (en) | 2016-09-15 | 2024-01-17 | Arvinas, Inc. | Indole derivatives as estrogen receptor degraders |
| SI3526202T1 (sl) | 2016-10-11 | 2025-04-30 | Arvinas Operations, Inc. | Spojine in postopki za ciljno razgradnjo androgenskih receptorjev |
| MX2019005007A (es) | 2016-11-01 | 2019-07-18 | Arvinas Inc | Protac dirigidos a la proteína tau y métodos asociados de uso. |
| IL266842B (en) | 2016-12-01 | 2022-09-01 | Arvinas Operations Inc | History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists |
| CN110753693A (zh) | 2016-12-23 | 2020-02-04 | 阿尔维纳斯运营股份有限公司 | Egfr蛋白水解靶向嵌合分子和相关使用方法 |
| IL325835A (en) | 2016-12-23 | 2026-03-01 | Univ Yale | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides |
| US10806737B2 (en) | 2016-12-23 | 2020-10-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| IL300417A (en) | 2017-01-26 | 2023-04-01 | Arvinas Operations Inc | Bifunctional benzothiophene compounds, preparations containing them and their use in therapy |
| IL319363A (en) | 2017-01-31 | 2025-05-01 | Arvinas Operations Inc | Cervalon ligands and bifunctional compounds containing them |
| EP3634960A1 (en) | 2017-06-09 | 2020-04-15 | Arvinas Operations, Inc. | Modulators of proteolysis and associated methods of use |
| EP4717317A3 (en) | 2017-06-20 | 2026-06-03 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| WO2019023553A1 (en) | 2017-07-28 | 2019-01-31 | Arvinas, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| AU2019249849C1 (en) | 2018-04-01 | 2022-09-29 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| CA3095912A1 (en) | 2018-04-13 | 2019-10-17 | Arvinas Operations, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| WO2019204354A1 (en) | 2018-04-16 | 2019-10-24 | C4 Therapeutics, Inc. | Spirocyclic compounds |
| EP3897631A4 (en) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | TARGETED PROTEIN BREAKDOWN |
| ES2995214T3 (en) | 2019-03-06 | 2025-02-07 | C4 Therapeutics Inc | Heterocyclic compounds for medical treatment |
| KR102947433B1 (ko) | 2019-04-12 | 2026-04-06 | 씨4 테라퓨틱스, 인코포레이티드 | 이카로스 및 아이올로스의 트리시클릭 분해제 |
| KR20220027196A (ko) * | 2019-06-27 | 2022-03-07 | 바이오젠 엠에이 인코포레이티드 | 이미다조[1,2-a]피리디닐 유도체 및 질병의 치료에서 이것들의 용도 |
| CN114585609B (zh) * | 2019-06-27 | 2024-07-30 | 比奥根Ma公司 | 2h-吲唑衍生物及其在疾病治疗中的用途 |
| PH12022500002A1 (en) * | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12558427B2 (en) * | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| EP4681715A3 (en) | 2019-12-20 | 2026-01-28 | C4 Therapeutics, Inc. | Isoindolinone and indazole compounds for the degradation of egfr |
| CN116194453A (zh) | 2019-12-20 | 2023-05-30 | 卡里科生命科学有限责任公司 | 蛋白质酪氨酸磷酸酶降解剂及其使用方法 |
| US20230122219A1 (en) * | 2020-02-03 | 2023-04-20 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| EP4267576A1 (en) * | 2020-12-22 | 2023-11-01 | Biogen MA Inc. | Imidazo[1,2-a]pyridine derivatives as irak4 inhibitors and their use in the treatment of disease |
| MX2023012981A (es) * | 2021-05-03 | 2024-01-11 | Nurix Therapeutics Inc | Compuestos para inhibir o degradar proteinas objetivo, composiciones que los comprenden, metodos para su preparacion y metodos para usarlos. |
-
2022
- 2022-07-07 CA CA3224732A patent/CA3224732A1/en active Pending
- 2022-07-07 WO PCT/US2022/073522 patent/WO2023283610A1/en not_active Ceased
- 2022-07-07 AU AU2022308734A patent/AU2022308734A1/en active Pending
- 2022-07-07 EP EP22748718.8A patent/EP4367113A1/en active Pending
- 2022-07-07 KR KR1020247004514A patent/KR20240035526A/ko active Pending
- 2022-07-07 UY UY0001039844A patent/UY39844A/es unknown
- 2022-07-07 MX MX2024000395A patent/MX2024000395A/es unknown
- 2022-07-07 JP JP2024500319A patent/JP2024527570A/ja active Pending
- 2022-07-07 TW TW111125548A patent/TW202321236A/zh unknown
- 2022-07-07 IL IL309941A patent/IL309941A/en unknown
- 2022-07-07 US US18/576,940 patent/US20240343733A1/en active Pending
-
2024
- 2024-01-04 JO JOJO/P/2024/0002A patent/JOP20240002A1/ar unknown
- 2024-01-04 CL CL2024000020A patent/CL2024000020A1/es unknown
- 2024-02-05 CO CONC2024/0001193A patent/CO2024001193A2/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024525580A5 (cg-RX-API-DMAC10.html) | ||
| AU2022201082B2 (en) | Benzimidazole compounds as c-Kit inhibitors | |
| KR102642408B1 (ko) | 피루브산 키나아제 조절제 및 이의 용도 | |
| US8080561B2 (en) | Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors | |
| RU2689777C1 (ru) | Конденсированные трициклические производные бензимидазолов в качестве модуляторов активности tnf | |
| WO2024151547A1 (en) | Targeted degradation of vav1 | |
| CN120081822A (zh) | 经取代的吲哚化合物及其使用方法 | |
| CN115811977A (zh) | 变构egfr抑制剂及其使用方法 | |
| JP2023139235A (ja) | Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド | |
| AU2021285032A1 (en) | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer | |
| JP2024525580A (ja) | Ｉｒａｋ４タンパク質の分解をターゲティングするための化合物 | |
| WO2013025425A1 (en) | Soluble guanylate cyclase activators | |
| JP7854219B2 (ja) | ペプチジルニトリル化合物及びその使用 | |
| WO2014001973A1 (en) | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS | |
| CN104010504A (zh) | 作为mGluR2负变构调节剂的喹啉甲酰胺和喹啉甲腈的衍生物、组合物、及其用途 | |
| EP4267564A1 (en) | Indole derivatives useful in treating conditions associated with cgas | |
| KR20150127724A (ko) | 포스포디에스테라제 타입 10a의 신규 억제제 화합물 | |
| CN118974036A (zh) | Raf激酶的抑制剂 | |
| CN117500499A (zh) | 经取代的吲哚化合物及其使用方法 | |
| TR201807696T4 (tr) | 5-hidroksi-4-(trifluorometil)pirazolopiridin türevi. | |
| EP4267571A1 (en) | Pyrrolo[3,2-b]pyridine derivatives useful in treating conditions associated with cgas | |
| JP2026506844A (ja) | Ａｋｔ１の共有結合改質剤およびその使用 | |
| AU2024322339A1 (en) | 3h-imidazo[4,5-b]pyridine compounds as non-covalent modifiers of akt1 and uses thereof | |
| JP7688449B2 (ja) | ピリジン縮合環系化合物とその製造方法、中間体、組成物及び使用 | |
| WO2025247390A1 (zh) | 可用作glp-1r激动剂的杂双环化合物 |