JP2024526762A - Ｊａｋ阻害剤を調製するためのプロセス及び中間体 - Google Patents

Ｊａｋ阻害剤を調製するためのプロセス及び中間体 Download PDF

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JP2024526762A
JP2024526762A JP2024501966A JP2024501966A JP2024526762A JP 2024526762 A JP2024526762 A JP 2024526762A JP 2024501966 A JP2024501966 A JP 2024501966A JP 2024501966 A JP2024501966 A JP 2024501966A JP 2024526762 A JP2024526762 A JP 2024526762A
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compound
formula
salt
reaction
reacting
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JP2024526762A5 (https=
Inventor
チョウ，ジアチェン
チェン，シリ
ジア，ジョンジアン
リウ，ピンリー
メローニ，デイビッド
パン，ヨンチュン
スー，ナイジン
シア，マイケル
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2024501966A 2021-07-12 2022-07-11 Ｊａｋ阻害剤を調製するためのプロセス及び中間体 Pending JP2024526762A (ja)

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US202163220752P 2021-07-12 2021-07-12
US63/220,752 2021-07-12
PCT/US2022/073599 WO2023288197A1 (en) 2021-07-12 2022-07-11 Process and intermediates for preparing baricitinib

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JP2024526762A true JP2024526762A (ja) 2024-07-19
JP2024526762A5 JP2024526762A5 (https=) 2025-07-18

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US (2) US12071439B2 (https=)
EP (1) EP4370504A1 (https=)
JP (1) JP2024526762A (https=)
CN (1) CN118317946A (https=)
CA (1) CA3226714A1 (https=)
WO (1) WO2023288197A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL300557A (en) 2020-08-18 2023-04-01 Incyte Corp Process and intermediates for preparing a JAK1 inhibitor
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CN117903032A (zh) * 2022-10-12 2024-04-19 重庆博腾制药科技股份有限公司 一种巴瑞替尼中间体的制备方法及制备巴瑞替尼的方法
CN121135621A (zh) * 2024-06-07 2025-12-16 上海长森药业有限公司 一种jak抑制剂的制备方法及其中间体

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US20230059389A1 (en) 2023-02-23
WO2023288197A1 (en) 2023-01-19
US12071439B2 (en) 2024-08-27
US20240368171A1 (en) 2024-11-07
CA3226714A1 (en) 2023-01-19
EP4370504A1 (en) 2024-05-22
CN118317946A (zh) 2024-07-09

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