JP2024525993A5 - - Google Patents

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Publication number
JP2024525993A5
JP2024525993A5 JP2024527720A JP2024527720A JP2024525993A5 JP 2024525993 A5 JP2024525993 A5 JP 2024525993A5 JP 2024527720 A JP2024527720 A JP 2024527720A JP 2024527720 A JP2024527720 A JP 2024527720A JP 2024525993 A5 JP2024525993 A5 JP 2024525993A5
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JP
Japan
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alkyl
heterocyclyl
aryl
cycloalkyl
pharmaceutically acceptable
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JP2024527720A
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English (en)
Japanese (ja)
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JP2024525993A (ja
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Priority claimed from PCT/CN2022/106447 external-priority patent/WO2023001141A1/en
Publication of JP2024525993A publication Critical patent/JP2024525993A/ja
Publication of JP2024525993A5 publication Critical patent/JP2024525993A5/ja
Pending legal-status Critical Current

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JP2024527720A 2021-07-23 2022-07-19 Kras g12d阻害剤およびその使用 Pending JP2024525993A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2021108280 2021-07-23
CNPCT/CN2021/108280 2021-07-23
CN2021143176 2021-12-30
CNPCT/CN2021/143176 2021-12-30
PCT/CN2022/106447 WO2023001141A1 (en) 2021-07-23 2022-07-19 Kras g12d inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
JP2024525993A JP2024525993A (ja) 2024-07-12
JP2024525993A5 true JP2024525993A5 (cg-RX-API-DMAC10.html) 2025-07-29

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ID=84979988

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JP2024527720A Pending JP2024525993A (ja) 2021-07-23 2022-07-19 Kras g12d阻害剤およびその使用

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US (1) US20240376123A1 (cg-RX-API-DMAC10.html)
EP (1) EP4373827A4 (cg-RX-API-DMAC10.html)
JP (1) JP2024525993A (cg-RX-API-DMAC10.html)
KR (1) KR20240087636A (cg-RX-API-DMAC10.html)
CN (1) CN117242079A (cg-RX-API-DMAC10.html)
AU (1) AU2022314009A1 (cg-RX-API-DMAC10.html)
CA (1) CA3226720A1 (cg-RX-API-DMAC10.html)
WO (1) WO2023001141A1 (cg-RX-API-DMAC10.html)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021085653A1 (en) 2019-10-31 2021-05-06 Taiho Pharmaceutical Co., Ltd. 4-aminobut-2-enamide derivatives and salts thereof
EP4067343A4 (en) 2019-11-29 2024-01-03 Taiho Pharmaceutical Co., Ltd. NEW PHENOLIC COMPOUND OR SALT THEREOF
US12702658B2 (en) 2020-04-24 2026-08-11 Taiho Pharmaceutical Co., Ltd. Anticancer combination therapy with N-(1-acryloyl-azetidin-3-yl)-2-((1H-indazol-3-yl)amino)methyl)-1H-imidazole-5-carboxamide inhibitor of KRAS-G12C
WO2021215544A1 (en) 2020-04-24 2021-10-28 Taiho Pharmaceutical Co., Ltd. Kras g12d protein inhibitors
WO2022109487A1 (en) 2020-11-23 2022-05-27 Merck Sharp & Dohme Corp. Spirocyclic-substituted 6,7-dihydro-pyrano[2,3-d]pyrimidine inhibitors of kras g12c mutant
CN116867792A (zh) * 2021-02-09 2023-10-10 基因泰克公司 四环氧氮杂䓬化合物及其用途
CN117043167A (zh) 2021-03-17 2023-11-10 劲方医药科技(上海)有限公司 嘧啶并环类化合物及其制法和用途
MX2023015533A (es) * 2021-06-21 2024-01-23 Jiangsu Hengrui Pharmaceuticals Co Ltd Compuesto tetraciclico fusionado, metodo de preparacion y aplicacion en medicina.
TW202315626A (zh) * 2021-08-31 2023-04-16 大陸商勁方醫藥科技(上海)有限公司 嘧啶并環類化合物及其製法和用途
JP2025504041A (ja) * 2022-01-30 2025-02-06 シャンハイ ファーマシューティカルズ ホールディング カンパニー,リミティド キノリン系化合物及びその使用
CA3243798A1 (en) 2022-02-09 2023-08-17 Quanta Therapeutics, Inc. Kras Modulators and Their Uses
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
EP4511127A1 (en) * 2022-04-21 2025-02-26 Gilead Sciences, Inc. Kras g12d modulating compounds
AU2023265688A1 (en) 2022-05-06 2024-10-17 PAQ Therapeutics Inc. Kras g12d proteolysis targeting chimeras
CN119365467A (zh) * 2022-05-19 2025-01-24 基因泰克公司 氮杂-四环氧氮杂䓬化合物及其用途
WO2023230190A1 (en) 2022-05-25 2023-11-30 Quanta Therapeutics, Inc. Pyrimidine based modulators and uses thereof
EP4536364A1 (en) 2022-06-10 2025-04-16 Revolution Medicines, Inc. Macrocyclic ras inhibitors
TW202409051A (zh) * 2022-07-27 2024-03-01 大陸商江蘇恆瑞醫藥股份有限公司 稠環類化合物、其製備方法及其在醫藥上的應用
KR20250037564A (ko) * 2022-07-29 2025-03-17 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Kras g12d 억제제를 포함하는 약학적 조성물
AU2023320565A1 (en) 2022-08-05 2025-01-23 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
WO2024032704A1 (en) * 2022-08-11 2024-02-15 Beigene, Ltd. Heterocyclic compounds, compositions thereof, and methods of treatment therewith
WO2024041573A1 (en) * 2022-08-25 2024-02-29 Zai Lab (Shanghai) Co., Ltd. Fused multi-heterocyclic compounds as kras g12d modulators and uses thereof
WO2024051721A1 (en) * 2022-09-07 2024-03-14 Nikang Therapeutics, Inc. Tetracyclic derivatives as kras inhibitors
TW202426459A (zh) * 2022-09-23 2024-07-01 大陸商勁方醫藥科技(上海)有限公司 嘧啶并環類化合物及其製法和用途
TW202440594A (zh) * 2022-12-07 2024-10-16 大陸商北京加科思新藥研發有限公司 稠環化合物及其用途
TW202430184A (zh) * 2022-12-20 2024-08-01 大陸商江蘇恒瑞醫藥股份有限公司 Kras g12d抑制劑的結晶形式及製備方法
CN122187841A (zh) * 2023-01-18 2026-06-12 苏州赞荣医药科技有限公司 Kras g12d抑制剂和其用途
WO2024234360A1 (en) * 2023-05-18 2024-11-21 Nikang Therapeutics , Inc. Tetracyclic derivatives as kras inhibitors
WO2024159471A1 (en) * 2023-02-02 2024-08-08 Nikang Therapeutics , Inc. Tetracyclic derivatives as kras inhibitors
WO2024159470A1 (en) * 2023-02-02 2024-08-08 Nikang Therapeutics , Inc. Tetracyclic derivatives as kras inhibitors
WO2024160225A1 (en) * 2023-02-02 2024-08-08 Nikang Therapeutics, Inc. Tetracyclic derivatives as kras inhibitors
EP4680609A1 (en) 2023-03-15 2026-01-21 Quanta Therapeutics, Inc. Kras modulators and uses thereof
WO2024197503A1 (en) * 2023-03-27 2024-10-03 Nikang Therapeutics , Inc. Tricyclic derivatives as kras inhibitors
CN121487738A (zh) 2023-03-30 2026-02-06 锐新医药公司 诱导ras gtp水解的组合物和其用途
WO2024208305A1 (zh) * 2023-04-07 2024-10-10 江苏恒瑞医药股份有限公司 稠合四环类化合物、其制备方法及其在医药上的应用
WO2024211712A1 (en) 2023-04-07 2024-10-10 Revolution Medicines, Inc. Condensed macrocyclic compounds as ras inhibitors
CN121487951A (zh) 2023-04-07 2026-02-06 锐新医药公司 大环ras抑制剂
WO2024213979A1 (en) * 2023-04-10 2024-10-17 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
WO2024215754A1 (en) * 2023-04-11 2024-10-17 Gilead Sciences, Inc. Kras modulating compounds
EP4695261A1 (en) 2023-04-14 2026-02-18 Revolution Medicines, Inc. Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
AU2024251341A1 (en) 2023-04-14 2025-10-16 Revolution Medicines, Inc. Crystalline forms of a ras inhibitor
WO2024218686A1 (en) * 2023-04-20 2024-10-24 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
WO2024230707A1 (zh) * 2023-05-07 2024-11-14 上海医药集团股份有限公司 一种喹唑啉类化合物及其应用
EP4716531A2 (en) * 2023-05-22 2026-04-01 Board of Regents, The University of Texas System Heterocyclic compounds as nras inhibitors
WO2025016899A1 (en) 2023-07-19 2025-01-23 Bayer Aktiengesellschaft Spirocyclic compounds for the treatment of cancer
WO2025026903A1 (en) 2023-07-31 2025-02-06 Bayer Aktiengesellschaft Imidazo pyrimidine compounds for the treatment of cancer
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
EP4766713A2 (en) * 2023-08-25 2026-07-01 Ensem Therapeutics, Inc. TETRACYCLIC DERIVATIVES, COMPOSITIONS AND ASSOCIATED PROCESSES
WO2025045141A1 (en) * 2023-08-31 2025-03-06 Suzhou Zanrong Pharma Limited Kras inhibitors and uses thereof
EP4774280A1 (en) * 2023-09-08 2026-07-15 Gilead Sciences, Inc. Kras g12d modulating compounds
US20250109147A1 (en) * 2023-09-08 2025-04-03 Gilead Sciences, Inc. Kras g12d modulating compounds
WO2025059040A1 (en) * 2023-09-11 2025-03-20 Newave Pharmaceutical Inc. Mutant kras modulators and uses thereof
KR20260087586A (ko) 2023-10-03 2026-06-11 피에이큐 테라퓨틱스 인코포레이티드 Kras 단백질분해 표적화 키메라
US20250114346A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
KR20260110993A (ko) 2023-10-09 2026-07-14 인사이트 코포레이션 Kras g12d 억제제 및 egfr 억제제를 포함하는 암 치료용 조합
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
KR20260096846A (ko) 2023-10-20 2026-06-24 머크 샤프 앤드 돔 엘엘씨 Kras 단백질의 소분자 억제제
TW202540122A (zh) * 2023-11-22 2025-10-16 美商建南德克公司 Kras-g12d之氮雜-四環氧氮呯抑制劑的多晶型物及合成方法
WO2025111582A1 (en) * 2023-11-22 2025-05-30 Genentech, Inc. Aza-tetracyclic oxazepine inhibitors of kras-g12d
WO2025123318A1 (en) * 2023-12-15 2025-06-19 Shanghai Blueray Biopharma Co., Ltd. TETRACYCLIC DERIVATIVES AS K-Ras G12D INHIBITORS
WO2025146194A1 (en) * 2024-01-05 2025-07-10 Jacobio Pharmaceuticals Co., Ltd. Fused tetracyclic compounds and use thereof
AU2025209726A1 (en) * 2024-01-17 2026-07-09 Suzhou Zanrong Pharma Limited Kras inhibitors and uses thereof
CN119684315B (zh) * 2024-01-26 2026-05-12 苏州盛迪亚生物医药有限公司 一种苯并噻吩取代稠环化合物的结晶形式及其制备方法
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025194134A1 (en) * 2024-03-15 2025-09-18 Genentech, Inc. Linearly substituted oxazepin-5-one kras-g12d inhibitors
WO2025217319A1 (en) * 2024-04-09 2025-10-16 Kestrel Therapeutics Inc. Ras inhibitors and methods of use thereof
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026035945A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload
TW202615038A (zh) 2024-08-07 2026-04-16 美商太斯萊特醫藥美國有限責任公司 包含拓樸異構酶有效載荷之靶向kras之共價誘導之藥物結合物
WO2026039659A1 (en) * 2024-08-14 2026-02-19 Board Of Regents, The University Of Texas System Heterocyclic compounds as ras inhibitors
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026064520A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload
WO2026064527A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer
WO2026072560A1 (en) * 2024-09-30 2026-04-02 Ensem Therapeutics, Inc. Tetracyclic derivatives, compositions and methods thereof
WO2026080226A1 (en) * 2024-10-08 2026-04-16 Ensem Therapeutics, Inc. Tricyclic derivatives, compositions and methods thereof
WO2026090116A2 (en) 2024-10-21 2026-04-30 Revolution Medicines, Inc. Ras inhibitors
WO2026090245A1 (en) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Use of ras inhibitors for treating cancer
US20260108528A1 (en) 2024-10-22 2026-04-23 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2026090333A1 (en) 2024-10-23 2026-04-30 Incyte Corporation Combination using a kras g12d inhibitor and chemotherapy combinations as well as their use in the treatment of cancer
US20260137674A1 (en) 2024-10-23 2026-05-21 Incyte Corporation Combination therapy using a kras g12d inhibitor, and a nucleoside analog, and/or a microtubule inhibitor
WO2026106912A1 (en) 2024-11-12 2026-05-21 Revolution Medicines, Inc. Ras inhibitors
WO2026112187A1 (en) * 2024-11-20 2026-05-28 Quanta Therapeutics, Inc. Kras modulators and uses thereof
WO2026112260A1 (en) 2024-11-21 2026-05-28 Revolution Medicines, Inc. Ras inhibitors
WO2026122764A2 (en) 2024-12-06 2026-06-11 Revolution Medicines, Inc. Ras inhibitors
WO2026128688A2 (en) 2024-12-13 2026-06-18 Revolution Medicines, Inc. Ras inhibitors
WO2026158694A1 (zh) * 2025-01-27 2026-07-30 江苏亚虹医药科技股份有限公司 Cdk抑制剂及其制备方法和用途
WO2026161839A1 (en) 2025-01-27 2026-07-30 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018206539A1 (en) * 2017-05-11 2018-11-15 Astrazeneca Ab Heteroaryl compounds that inhibit g12c mutant ras proteins
US10597405B2 (en) * 2017-12-08 2020-03-24 Astrazeneca Ab Chemical compounds
TW202012415A (zh) * 2018-05-08 2020-04-01 瑞典商阿斯特捷利康公司 化學化合物
EP3964516A4 (en) * 2019-04-28 2023-01-11 Genfleet Therapeutics (Shanghai) Inc. OXAAZACHUINAZOLINE-7( 8H)-KETONE COMPOUND, PROCESS FOR ITS PRODUCTION AND ITS PHARMACEUTICAL APPLICATION
CN113396147B (zh) * 2019-05-31 2024-06-18 上海翰森生物医药科技有限公司 芳香杂环类衍生物调节剂、其制备方法和应用
WO2020259573A1 (zh) * 2019-06-25 2020-12-30 南京明德新药研发有限公司 作为kras g12c突变蛋白抑制剂的七元杂环类衍生物
WO2021000885A1 (zh) * 2019-07-01 2021-01-07 江苏恒瑞医药股份有限公司 喹唑啉酮类衍生物、其制备方法及其在医药上的应用
CN114195804A (zh) * 2019-07-30 2022-03-18 上海凌达生物医药有限公司 一类哌啶稠环类化合物、制备方法和用途
CN112300194B (zh) * 2019-07-30 2022-01-14 上海凌达生物医药有限公司 一类稠环吡啶酮类化合物、制备方法和用途
IL290276B2 (en) * 2019-08-02 2026-05-01 Shanghai Jemincare Pharmaceuticals Co Ltd Tetracyclic compounds, method for their preparation and use
CN112390818B (zh) * 2019-08-12 2023-08-22 劲方医药科技(上海)有限公司 取代的杂芳环并二氢嘧啶酮衍生物,其制法与医药上的用途
CN114615981B (zh) * 2019-08-29 2024-04-12 米拉蒂治疗股份有限公司 Kras g12d抑制剂
CN116947885B (zh) * 2019-09-20 2026-01-23 上海济煜医药科技股份有限公司 稠合吡啶酮类化合物及其制备方法和应用
BR112022008375A2 (pt) * 2019-10-30 2022-07-12 Genfleet Therapeutics Shanghai Inc Composto cíclico heterocíclico fundido substituído, método de preparação e uso farmacêutico deste
CN113321654B (zh) * 2020-02-28 2022-05-03 上海济煜医药科技有限公司 作为激酶抑制剂的稠合吡啶酮类化合物
AU2021248363B2 (en) * 2020-04-03 2024-02-15 Medshine Discovery Inc. Octahydropyrazinodiazanaphthyridine dione compounds
TW202144349A (zh) * 2020-04-30 2021-12-01 大陸商上海科州藥物研發有限公司 作為kras抑制劑的雜環化合物的製備及其應用方法
CN113929681A (zh) * 2020-07-14 2022-01-14 浙江海正药业股份有限公司 四环类衍生物及其制备方法和用途
CN113980032B (zh) * 2020-07-27 2023-06-16 江苏恒瑞医药股份有限公司 稠合四环类衍生物、其制备方法及其在医药上的应用
CN114195788B (zh) * 2020-09-17 2024-10-01 苏州闻天医药科技有限公司 一类四环化合物及其用途
KR20230121625A (ko) * 2020-12-15 2023-08-18 뉴 잉글랜드 바이오랩스, 인크 폴리뉴클레오타이드의 개선된 시험관내 조립을 위한조성물 및 방법
CN116670136A (zh) * 2020-12-31 2023-08-29 正大天晴药业集团股份有限公司 四环类化合物及其医药用途
CN117043167A (zh) * 2021-03-17 2023-11-10 劲方医药科技(上海)有限公司 嘧啶并环类化合物及其制法和用途
CN115175354B (zh) * 2021-04-04 2025-07-08 华为技术有限公司 数据传输方法及装置
MX2023015533A (es) * 2021-06-21 2024-01-23 Jiangsu Hengrui Pharmaceuticals Co Ltd Compuesto tetraciclico fusionado, metodo de preparacion y aplicacion en medicina.
CN115557974A (zh) * 2021-07-02 2023-01-03 上海迪诺医药科技有限公司 Kras g12d抑制剂及其应用
EP4433422A1 (de) * 2021-11-16 2024-09-25 Wacker Chemie AG Silicium-subhalogenid-enthaltende kompositpartikel
EP4511127A1 (en) * 2022-04-21 2025-02-26 Gilead Sciences, Inc. Kras g12d modulating compounds

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