JP2022548255A5 - - Google Patents

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Publication number
JP2022548255A5
JP2022548255A5 JP2022516295A JP2022516295A JP2022548255A5 JP 2022548255 A5 JP2022548255 A5 JP 2022548255A5 JP 2022516295 A JP2022516295 A JP 2022516295A JP 2022516295 A JP2022516295 A JP 2022516295A JP 2022548255 A5 JP2022548255 A5 JP 2022548255A5
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JP
Japan
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alkyl
compound
cancer
carcinoma
cyano
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JP2022516295A
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Japanese (ja)
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JP2022548255A (ja
JP7789662B2 (ja
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Priority claimed from PCT/US2020/050457 external-priority patent/WO2021050915A1/en
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Publication of JP2022548255A5 publication Critical patent/JP2022548255A5/ja
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JP2022516295A 2019-09-12 2020-09-11 Mta協働prmt5阻害剤 Active JP7789662B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962899575P 2019-09-12 2019-09-12
US62/899,575 2019-09-12
US201962942833P 2019-12-03 2019-12-03
US62/942,833 2019-12-03
US202062961371P 2020-01-15 2020-01-15
US62/961,371 2020-01-15
US202062994927P 2020-03-26 2020-03-26
US62/994,927 2020-03-26
US202063060261P 2020-08-03 2020-08-03
US63/060,261 2020-08-03
PCT/US2020/050457 WO2021050915A1 (en) 2019-09-12 2020-09-11 Mta-cooperative prmt5 inhibitors

Publications (3)

Publication Number Publication Date
JP2022548255A JP2022548255A (ja) 2022-11-17
JP2022548255A5 true JP2022548255A5 (cg-RX-API-DMAC10.html) 2023-09-13
JP7789662B2 JP7789662B2 (ja) 2025-12-22

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JP2022516295A Active JP7789662B2 (ja) 2019-09-12 2020-09-11 Mta協働prmt5阻害剤

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US (3) US11492351B2 (cg-RX-API-DMAC10.html)
EP (1) EP4028388A1 (cg-RX-API-DMAC10.html)
JP (1) JP7789662B2 (cg-RX-API-DMAC10.html)
KR (1) KR20220083691A (cg-RX-API-DMAC10.html)
CN (2) CN120208880A (cg-RX-API-DMAC10.html)
AU (1) AU2020345899B2 (cg-RX-API-DMAC10.html)
BR (1) BR112022004248A2 (cg-RX-API-DMAC10.html)
CA (1) CA3150515A1 (cg-RX-API-DMAC10.html)
CL (1) CL2022000603A1 (cg-RX-API-DMAC10.html)
CO (1) CO2022004513A2 (cg-RX-API-DMAC10.html)
IL (2) IL290341B2 (cg-RX-API-DMAC10.html)
MX (1) MX2022002938A (cg-RX-API-DMAC10.html)
NO (1) NO20220309A1 (cg-RX-API-DMAC10.html)
PH (1) PH12022550399A1 (cg-RX-API-DMAC10.html)
SA (1) SA522431915B1 (cg-RX-API-DMAC10.html)
TW (1) TW202122387A (cg-RX-API-DMAC10.html)
WO (1) WO2021050915A1 (cg-RX-API-DMAC10.html)

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CN118946549A (zh) * 2022-04-22 2024-11-12 北京望实智慧科技有限公司 稠和哒嗪酮化合物作为prmt5抑制剂
CN117843634A (zh) * 2022-05-24 2024-04-09 上海美悦生物科技发展有限公司 Sik抑制剂及其组合物、制备方法和用途
CN116178347B (zh) * 2022-06-29 2025-07-04 苏州浦合医药科技有限公司 Prmt5-mta抑制剂
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CN117430596A (zh) * 2022-07-13 2024-01-23 上海海和药物研究开发股份有限公司 二并环类mat2a抑制剂及其用途
WO2024022186A1 (zh) * 2022-07-29 2024-02-01 四川科伦博泰生物医药股份有限公司 甲基吡唑化合物、包含其的药物组合物及其制备方法和用途
WO2024027703A1 (zh) * 2022-08-02 2024-02-08 上海艾力斯医药科技股份有限公司 一种prmt5抑制剂、其制备方法及应用
WO2024038004A1 (en) * 2022-08-15 2024-02-22 Astrazeneca Ab Mta-cooperative prmt5 inhibitors for use in the treatment of cancer
KR20250056257A (ko) 2022-09-01 2025-04-25 미라티 테라퓨틱스, 인크. 암의 치료를 위한 prmt5 억제제 및 bcl-2 패밀리 억제제를 사용하는 조합 요법
KR20250108633A (ko) * 2022-10-25 2025-07-15 탱고 테라퓨틱스, 인크. 결정질 형태, 약제학적 조성물 및 이의 사용 방법
CN120265615A (zh) * 2022-11-29 2025-07-04 正大天晴药业集团股份有限公司 含有二氢酞嗪的化合物
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KR102818470B1 (ko) * 2023-02-23 2025-06-10 한양대학교 산학협력단 신규한 아미노락톤 유도체 및 이의 신규한 제조방법
PE20260121A1 (es) 2023-04-21 2026-01-16 Gilead Sciences Inc Inhibidores de prmt5 y usos de los mismos
CN121752566A (zh) * 2023-06-16 2026-03-27 中山优理生物医药有限公司 一种氨基吡啶类化合物、其制备方法、包含其药物组合物及其应用
CN121127465A (zh) 2023-07-14 2025-12-12 江苏亚虹医药科技股份有限公司 蛋白质精氨酸酶甲基转移酶-5抑制剂及其医药用途
IL326348A (en) 2023-08-08 2026-04-01 Mirati Therapeutics Inc Methods and compositions for treating malignant peripheral nerve sheath tumors
WO2025031468A1 (zh) 2023-08-09 2025-02-13 江苏恒瑞医药股份有限公司 杂芳基化合物、其制备方法及其在医药上的应用
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WO2025064286A1 (en) * 2023-09-19 2025-03-27 Mirati Therapeutics, Inc. Stable 4-(aminomethyl)-6-(phenylpyrazolyl)phthalazinone compositions and processes for preparation thereof
WO2025064750A1 (en) 2023-09-20 2025-03-27 Ideaya Biosciences, Inc. Combination therapy with a parg inhibitor
CN121866246A (zh) * 2023-09-20 2026-04-14 西藏海思科制药有限公司 一种含氰基的杂环化合物及其用途
WO2025072544A1 (en) 2023-09-27 2025-04-03 Ideaya Biosciences, Inc. Sulfonamino indazole compounds as inhibitors of parg
WO2025068985A1 (en) * 2023-09-28 2025-04-03 Beigene Switzerland Gmbh 1-(1-oxo-1,2-dihydrophthalazin-6-yl)cycloalkyl-1-carboxamide derivatives as mta-cooperative inhibitors of prmt5
TW202532064A (zh) * 2023-11-28 2025-08-16 大陸商正大天晴藥業集團股份有限公司 含有雜環二氫酞嗪的化合物
WO2025180390A1 (zh) * 2024-02-27 2025-09-04 烨辉医药科技(上海)有限公司 具有四环并环结构的mta协同性prmt5抑制剂化合物
US20250304556A1 (en) 2024-04-02 2025-10-02 Mirati Therapeutics, Inc. Processes for preparation of prmt5 inhibitors and intermediates for making the same
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