JP2024525797A5 - - Google Patents
Info
- Publication number
- JP2024525797A5 JP2024525797A5 JP2024502035A JP2024502035A JP2024525797A5 JP 2024525797 A5 JP2024525797 A5 JP 2024525797A5 JP 2024502035 A JP2024502035 A JP 2024502035A JP 2024502035 A JP2024502035 A JP 2024502035A JP 2024525797 A5 JP2024525797 A5 JP 2024525797A5
- Authority
- JP
- Japan
- Prior art keywords
- heterocycloalkyl
- independently selected
- heteroatoms independently
- bond
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163221905P | 2021-07-14 | 2021-07-14 | |
| US63/221,905 | 2021-07-14 | ||
| PCT/US2022/037029 WO2023287928A1 (en) | 2021-07-14 | 2022-07-13 | Bifunctional compounds for degrading btk with diminished imid activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024525797A JP2024525797A (ja) | 2024-07-12 |
| JP2024525797A5 true JP2024525797A5 (https=) | 2025-07-22 |
Family
ID=82799901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024502035A Pending JP2024525797A (ja) | 2021-07-14 | 2022-07-13 | 減少したＩＭｉＤ活性を伴ってＢＴＫを分解するための二官能性化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240336595A1 (https=) |
| EP (1) | EP4370123A1 (https=) |
| JP (1) | JP2024525797A (https=) |
| KR (1) | KR20240035837A (https=) |
| CN (1) | CN118019538A (https=) |
| AU (1) | AU2022310182A1 (https=) |
| CA (1) | CA3225367A1 (https=) |
| IL (1) | IL309796A (https=) |
| WO (1) | WO2023287928A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004191A (es) | 2018-10-15 | 2021-05-27 | Nurix Therapeutics Inc | Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma. |
| US12582722B2 (en) | 2019-02-13 | 2026-03-24 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| WO2021113557A1 (en) | 2019-12-04 | 2021-06-10 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
| JP2024524480A (ja) * | 2021-07-01 | 2024-07-05 | ハンチョウ、ヘルズン、セラピューティクス、カンパニー、リミテッド | ブルトン型チロシンキナーゼ及びその突然変異体の分解剤、組成物並びにそれらの応用 |
| CA3236073A1 (en) | 2021-10-26 | 2023-05-04 | Robert J. Brown | Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk |
| WO2025162210A1 (zh) * | 2024-02-04 | 2025-08-07 | 上海超阳药业有限公司 | 一种具备降解酪氨酸蛋白激酶btk活性的化合物及其制备方法和用途 |
| WO2026005533A1 (ko) * | 2024-06-27 | 2026-01-02 | 한미약품 주식회사 | 신규한 이종이작용기 단백질 분해제 및 이의 용도 |
| CN120590386A (zh) * | 2025-05-30 | 2025-09-05 | 北京科莱博医药开发有限责任公司 | 一种喹喔啉类蛋白降解剂及其制备方法和应用 |
| CN120617259B (zh) * | 2025-06-05 | 2026-04-10 | 南昌大学第一附属医院 | Btk protac化合物nx-5948的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021004191A (es) | 2018-10-15 | 2021-05-27 | Nurix Therapeutics Inc | Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma. |
| WO2021113557A1 (en) | 2019-12-04 | 2021-06-10 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
-
2022
- 2022-07-13 AU AU2022310182A patent/AU2022310182A1/en active Pending
- 2022-07-13 CN CN202280061966.9A patent/CN118019538A/zh active Pending
- 2022-07-13 CA CA3225367A patent/CA3225367A1/en active Pending
- 2022-07-13 EP EP22751224.1A patent/EP4370123A1/en active Pending
- 2022-07-13 JP JP2024502035A patent/JP2024525797A/ja active Pending
- 2022-07-13 KR KR1020247004956A patent/KR20240035837A/ko active Pending
- 2022-07-13 WO PCT/US2022/037029 patent/WO2023287928A1/en not_active Ceased
- 2022-07-13 IL IL309796A patent/IL309796A/en unknown
- 2022-07-13 US US18/579,114 patent/US20240336595A1/en active Pending
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