JP2024524215A - Ｎｌｒｐ３阻害剤を調製するための方法 - Google Patents

Ｎｌｒｐ３阻害剤を調製するための方法 Download PDF

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Publication number
JP2024524215A
JP2024524215A JP2023578919A JP2023578919A JP2024524215A JP 2024524215 A JP2024524215 A JP 2024524215A JP 2023578919 A JP2023578919 A JP 2023578919A JP 2023578919 A JP2023578919 A JP 2023578919A JP 2024524215 A JP2024524215 A JP 2024524215A
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JP
Japan
Prior art keywords
group
typically
solvent
piperidine
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2023578919A
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English (en)
Japanese (ja)
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JP2024524215A5 (enExample
Inventor
バーラタ，マレシュ
サンカルブル，ジョゼフィーヌ・エリエット・フランソワーズ
フレイザー，ポール
モンディエール，レジス・ジャン・ジョルジュ
パルグナ，ジェッタ
トサッティ，パオロ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2024524215A publication Critical patent/JP2024524215A/ja
Publication of JP2024524215A5 publication Critical patent/JP2024524215A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/98—Nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023578919A 2021-06-23 2022-06-23 Ｎｌｒｐ３阻害剤を調製するための方法 Pending JP2024524215A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN202141028180 2021-06-23
IN202141028180 2021-06-23
PCT/EP2022/067126 WO2022268935A2 (en) 2021-06-23 2022-06-23 Novel process

Publications (2)

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JP2024524215A true JP2024524215A (ja) 2024-07-05
JP2024524215A5 JP2024524215A5 (enExample) 2025-06-27

Family

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JP2023578919A Pending JP2024524215A (ja) 2021-06-23 2022-06-23 Ｎｌｒｐ３阻害剤を調製するための方法

Country Status (12)

Country Link
US (1) US20240150291A1 (enExample)
EP (1) EP4359385A2 (enExample)
JP (1) JP2024524215A (enExample)
KR (1) KR20240024842A (enExample)
CN (1) CN118019727A (enExample)
AR (1) AR126215A1 (enExample)
AU (1) AU2022300325A1 (enExample)
CA (1) CA3219597A1 (enExample)
IL (1) IL308071A (enExample)
MX (1) MX2023014547A (enExample)
TW (1) TW202317514A (enExample)
WO (1) WO2022268935A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023220628A1 (en) * 2022-02-15 2024-05-23 F. Hoffmann-La Roche Ag Processes for the preparation of 1,2,3,5,6,7-hexahydro-s-indacene derivatives
WO2024133610A1 (en) * 2022-12-23 2024-06-27 F. Hoffmann-La Roche Ag Proccesses for the preparation of an nlrp3 inhibitor
WO2025036914A1 (en) 2023-08-16 2025-02-20 F. Hoffmann-La Roche Ag Process for the preparation of preparing 1-ethyl-n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

Citations (7)

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Publication number Priority date Publication date Assignee Title
JPH059102A (ja) * 1990-09-26 1993-01-19 Takeda Chem Ind Ltd 除草剤
JPH0586055A (ja) * 1991-01-24 1993-04-06 Ishihara Sangyo Kaisha Ltd 置換ピリジンスルホンアミド系化合物、それらの製造方法及びそれらを含有する除草剤
WO2010097087A1 (en) * 2009-02-25 2010-09-02 H. Lundbeck A/S Catecholamine derivatives and prodrugs thereof
WO2019008025A1 (en) * 2017-07-07 2019-01-10 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
WO2019211463A1 (en) * 2018-05-04 2019-11-07 Inflazome Limited Novel compounds
CN111393415A (zh) * 2020-04-30 2020-07-10 苏州信诺维医药科技有限公司 一种杂芳腈类化合物及其应用
WO2020157069A1 (en) * 2019-01-28 2020-08-06 NodThera Limited Amino heterocyclic compounds and uses thereof

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JP2001518069A (ja) * 1997-05-02 2001-10-09 ドクター・レディーズ・リサーチ・ファウンデーション 低脂質性、抗高血圧性特性を有する新規な抗糖尿病化合物、それらの製造方法及びそれらを含有する薬学的組成物
ATE342266T1 (de) * 2000-11-16 2006-11-15 Sankyo Co 1-methylcarbapenemderivate
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
MXPA04010172A (es) * 2002-04-18 2005-02-03 Schering Corp 1-(4-piperidinil)benzimidazolonas como antagonistas de histamina h3).
US7759387B2 (en) * 2003-10-08 2010-07-20 Piramal Life Sciences Limited Fibrinogen receptor antagonists and their use
DOP2006000009A (es) * 2005-01-13 2006-08-15 Arena Pharm Inc Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina
US8614215B2 (en) * 2007-02-22 2013-12-24 Merck Serono Sa Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks)
JP5898962B2 (ja) * 2012-01-11 2016-04-06 東京応化工業株式会社 レジスト組成物及びレジストパターン形成方法
EP3383853B1 (en) * 2015-12-01 2020-11-04 Merck Sharp & Dohme Corp. Homobispiperidinyl derivatives as liver x receptor (lxr) beta agonists for treating e.g. alzheimer's disease
GB201712282D0 (en) * 2017-07-31 2017-09-13 Nodthera Ltd Selective inhibitors of NLRP3 inflammasome
SG11202001164SA (en) * 2017-08-15 2020-03-30 Inflazome Ltd Novel sulfonamide carboxamide compounds
KR20210018199A (ko) * 2018-03-26 2021-02-17 씨4 테라퓨틱스, 인코포레이티드 이카로스의 분해를 위한 세레블론 결합제
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH059102A (ja) * 1990-09-26 1993-01-19 Takeda Chem Ind Ltd 除草剤
JPH0586055A (ja) * 1991-01-24 1993-04-06 Ishihara Sangyo Kaisha Ltd 置換ピリジンスルホンアミド系化合物、それらの製造方法及びそれらを含有する除草剤
WO2010097087A1 (en) * 2009-02-25 2010-09-02 H. Lundbeck A/S Catecholamine derivatives and prodrugs thereof
WO2019008025A1 (en) * 2017-07-07 2019-01-10 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
WO2019211463A1 (en) * 2018-05-04 2019-11-07 Inflazome Limited Novel compounds
WO2020157069A1 (en) * 2019-01-28 2020-08-06 NodThera Limited Amino heterocyclic compounds and uses thereof
CN111393415A (zh) * 2020-04-30 2020-07-10 苏州信诺维医药科技有限公司 一种杂芳腈类化合物及其应用

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Title
GIRISH V. AMBULGEKAR ET AL.: "A Novel and Facile Process for the Synthesis of Gliclazide", LETTERS IN ORGANIC CHEMISTRY, vol. 15, JPN6026015970, 2018, pages 760 - 765, ISSN: 0005844555 *
TAKASHI IKAWA ET AL.: "Selective N-alkylation of amines using nitriles under hydrogenation conditions: facile synthesis of", ORG. BIOMOL. CHEM, vol. 10, JPN6026015969, 2012, pages 293 - 304, ISSN: 0005844556 *

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Publication number Publication date
AR126215A1 (es) 2023-09-27
US20240150291A1 (en) 2024-05-09
CN118019727A (zh) 2024-05-10
TW202317514A (zh) 2023-05-01
AU2022300325A8 (en) 2023-11-16
MX2023014547A (es) 2024-04-29
AU2022300325A1 (en) 2023-11-02
WO2022268935A3 (en) 2023-02-02
KR20240024842A (ko) 2024-02-26
IL308071A (en) 2023-12-01
EP4359385A2 (en) 2024-05-01
CA3219597A1 (en) 2022-12-29
WO2022268935A2 (en) 2022-12-29

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