|
US6821963B2
(en)
|
1997-07-01 |
2004-11-23 |
Warner-Lambert Company |
4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
|
|
EP1482944A4
(en)
|
2002-03-13 |
2006-04-19 |
Array Biopharma Inc |
NZ ALKYL BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
KR100984595B1
(ko)
|
2002-03-13 |
2010-09-30 |
어레이 바이오파마 인크. |
Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
|
|
GB0215823D0
(en)
|
2002-07-09 |
2002-08-14 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
TW200520745A
(en)
|
2003-09-19 |
2005-07-01 |
Chugai Pharmaceutical Co Ltd |
Novel 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors
|
|
US7732616B2
(en)
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
US7517994B2
(en)
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
CN1905873A
(zh)
|
2003-11-19 |
2007-01-31 |
阵列生物制药公司 |
Mek的杂环抑制剂及其使用方法
|
|
TWI361066B
(en)
|
2004-07-26 |
2012-04-01 |
Chugai Pharmaceutical Co Ltd |
5-substituted-2-phenylamino benzamides as mek inhibitors
|
|
EP1838675A1
(en)
|
2004-11-24 |
2007-10-03 |
Laboratoires Serono S.A. |
Novel 4-arylamino pyridone derivatives as mek inhibitors for the treatment of hyperproliferative disorders
|
|
WO2006061712A2
(en)
|
2004-12-10 |
2006-06-15 |
Pfizer Inc. |
Use of mek inhibitors in treating abnormal cell growth
|
|
US7429667B2
(en)
|
2005-01-20 |
2008-09-30 |
Ardea Biosciences, Inc. |
Phenylamino isothiazole carboxamidines as MEK inhibitors
|
|
US20060211073A1
(en)
|
2005-03-21 |
2006-09-21 |
May Earl W |
Assay for B-Raf activity based on intrinsic MEK ATPase activity
|
|
ES2405785T3
(es)
|
2005-05-18 |
2013-06-03 |
Array Biopharma Inc. |
Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
|
|
US8101799B2
(en)
|
2005-07-21 |
2012-01-24 |
Ardea Biosciences |
Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
|
|
US20070172843A1
(en)
|
2005-09-12 |
2007-07-26 |
Conrad Susan E |
MEK interacting protein 1 as diagnostic and therapeutic target for breast cancer treatment and prevention
|
|
SI1934174T1
(sl)
|
2005-10-07 |
2011-08-31 |
Exelixis Inc |
Inhibitorji MEK in postopki za njihovo uporabo
|
|
WO2007071951A1
(en)
|
2005-12-21 |
2007-06-28 |
Astrazeneca Ab |
Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer
|
|
GB0601962D0
(en)
|
2006-01-31 |
2006-03-15 |
Ucb Sa |
Therapeutic agents
|
|
US7842836B2
(en)
|
2006-04-11 |
2010-11-30 |
Ardea Biosciences |
N-aryl-N'alkyl sulfamides as MEK inhibitors
|
|
JP5269762B2
(ja)
|
2006-04-18 |
2013-08-21 |
アーディア・バイオサイエンシーズ・インコーポレイテッド |
Ｍｅｋ阻害剤としてのピリドンスルホンアミドおよびピリドンスルファミド
|
|
EA200802050A1
(ru)
|
2006-04-19 |
2009-04-28 |
Лаборатуар Сероно Са |
Новые гетероарилзамещенные ариламинопиридиновые производные в качестве мек ингибиторов
|
|
US7772233B2
(en)
|
2006-04-19 |
2010-08-10 |
Merck Serono, S.A. |
Arylamino N-heteroaryl compounds as MEK inhibitors
|
|
GB0616214D0
(en)
|
2006-08-15 |
2006-09-27 |
Ucb Sa |
Therapeutic Agents
|
|
PL2101759T3
(pl)
|
2006-12-14 |
2019-05-31 |
Exelixis Inc |
Sposoby stosowania inhibitorów MEK
|
|
GB0625691D0
(en)
|
2006-12-22 |
2007-01-31 |
Astrazeneca Ab |
Combination product
|
|
KR20090111847A
(ko)
|
2007-01-19 |
2009-10-27 |
아디아 바이오사이언스즈 인크. |
Ｍｅｋ 억제제
|
|
GB0714384D0
(en)
|
2007-07-23 |
2007-09-05 |
Ucb Pharma Sa |
theraputic agents
|
|
CA2924436A1
(en)
|
2007-07-30 |
2009-02-05 |
Ardea Biosciences, Inc. |
Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use
|
|
EP2240494B1
(en)
|
2008-01-21 |
2016-03-30 |
UCB Biopharma SPRL |
Thieno-pyridine derivatives as mek inhibitors
|
|
GB0811304D0
(en)
|
2008-06-19 |
2008-07-30 |
Ucb Pharma Sa |
Therapeutic agents
|
|
US8841462B2
(en)
|
2008-07-01 |
2014-09-23 |
Robert A. Heald |
Bicyclic heterocycles as MEK kinase inhibitors
|
|
ES2426096T3
(es)
|
2008-07-01 |
2013-10-21 |
Genentech, Inc. |
Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización
|
|
CN102448938A
(zh)
|
2009-03-27 |
2012-05-09 |
阿迪生物科学公司 |
作为mek抑制剂的二氢吡啶磺酰胺和二氢吡啶硫酰胺
|
|
CN102666512B
(zh)
|
2009-10-13 |
2014-11-26 |
奥斯特姆医疗公司 |
对疾病治疗有用的mek抑制剂
|
|
CN102020651B
(zh)
|
2010-11-02 |
2012-07-18 |
北京赛林泰医药技术有限公司 |
6-芳基氨基吡啶酮甲酰胺mek抑制剂
|
|
US20120238599A1
(en)
|
2011-03-17 |
2012-09-20 |
Chemizon, A Division Of Optomagic Co., Ltd. |
Heterocyclic compounds as mek inhibitors
|
|
NZ629432A
(en)
|
2012-03-14 |
2017-01-27 |
Lupin Ltd |
Heterocyclyl compounds as mek inhibitors
|
|
FI3702351T3
(fi)
|
2012-10-19 |
2024-01-24 |
Array Biopharma Inc |
MEK-inhibiittorin käsittävä koostumus
|
|
EP2920144A4
(en)
|
2012-11-15 |
2016-06-29 |
Univ Holy Ghost Duquesne |
CARBOXYLIC ACID TESTER PRODRUG HEMMER FROM MEK
|
|
WO2014204263A1
(en)
|
2013-06-20 |
2014-12-24 |
The Asan Foundation |
Substituted pyridinone compounds as mek inhibitors
|
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
|
US10118911B2
(en)
|
2015-03-27 |
2018-11-06 |
Jiangsu Hengrui Medicine Co., Ltd. |
P-toluenesulfonate for MEK kinase inhibitor, and crystal form thereof and preparation method therefor
|
|
WO2016188472A1
(zh)
|
2015-05-28 |
2016-12-01 |
正大天晴药业集团股份有限公司 |
Mek抑制剂的药物组合物及其制备方法
|
|
KR102444509B1
(ko)
|
2016-05-18 |
2022-09-19 |
미라티 테라퓨틱스, 인크. |
Kras g12c 억제제
|
|
EP3558979B1
(en)
|
2016-12-22 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
|
|
LT3710439T
(lt)
|
2017-11-15 |
2023-05-10 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitoriai
|
|
BR112021012057A2
(pt)
*
|
2018-12-21 |
2021-10-19 |
Revolution Medicines, Inc. |
Compostos que participam de ligação cooperativa e usos dos mesmos
|
|
CN115315424A
(zh)
|
2019-10-15 |
2022-11-08 |
拜耳公司 |
2-甲基-氮杂-喹唑啉
|
|
PH12022551513A1
(en)
*
|
2019-12-20 |
2023-04-24 |
Mirati Therapeutics Inc |
Sos1 inhibitors
|
|
WO2021154929A1
(en)
*
|
2020-01-31 |
2021-08-05 |
Verastem, Inc. |
Combination therapy for treating abnormal cell growth
|
|
CN115942936A
(zh)
*
|
2020-06-24 |
2023-04-07 |
勃林格殷格翰国际有限公司 |
包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
|
|
CR20230402A
(es)
*
|
2021-01-19 |
2023-11-21 |
Lupin Ltd |
Combinaciones farmacéuticas de inhibidores de sos1 para tratar o prevenir cancer
|