JP2024516376A - Ｄｎａ依存性プロテインキナーゼの阻害剤ならびにその組成物及び使用 - Google Patents

Ｄｎａ依存性プロテインキナーゼの阻害剤ならびにその組成物及び使用 Download PDF

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JP2024516376A
JP2024516376A JP2023563189A JP2023563189A JP2024516376A JP 2024516376 A JP2024516376 A JP 2024516376A JP 2023563189 A JP2023563189 A JP 2023563189A JP 2023563189 A JP2023563189 A JP 2023563189A JP 2024516376 A JP2024516376 A JP 2024516376A
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dna
composition
cells
cell
pki
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JP2024516376A5 (enExample
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マエタニ，マイカ
ジェニー シー，シン
フォーゲット，アンソニー
プロデウス，アーロン
ヤジンスキー，ステファニー
パーマー，ルビナ，ギアレ
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インテリア セラピューティクス，インコーポレーテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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JP2023563189A 2021-04-17 2022-04-15 Ｄｎａ依存性プロテインキナーゼの阻害剤ならびにその組成物及び使用 Pending JP2024516376A (ja)

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US202163176225P 2021-04-17 2021-04-17
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PCT/US2022/025075 WO2022221696A1 (en) 2021-04-17 2022-04-15 Inhibitors of dna-dependent protein kinase and compositions and uses thereof

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US (1) US20240300977A1 (enExample)
EP (1) EP4323360A1 (enExample)
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KR (1) KR20240017791A (enExample)
CN (1) CN117940426A (enExample)
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WO2025128871A2 (en) 2023-12-13 2025-06-19 Renagade Therapeutics Management Inc. Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
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US20210008161A1 (en) * 2019-06-17 2021-01-14 Crispr Therapeutics Ag Methods and compositions for improved homology directed repair
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