CN117940426A - Dna依赖性蛋白质激酶抑制剂以及其组合物和用途 - Google Patents

Dna依赖性蛋白质激酶抑制剂以及其组合物和用途 Download PDF

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Publication number
CN117940426A
CN117940426A CN202280042815.9A CN202280042815A CN117940426A CN 117940426 A CN117940426 A CN 117940426A CN 202280042815 A CN202280042815 A CN 202280042815A CN 117940426 A CN117940426 A CN 117940426A
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dna
composition
cell
pki
cells
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Chinese (zh)
Inventor
M·梅塔尼
X·J·谢
A·福尔热
A·普罗德尤斯
S·亚辛斯基
R·G·帕尔马
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Intelia Therapeutics Co ltd
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Intelia Therapeutics Co ltd
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Publication of CN117940426A publication Critical patent/CN117940426A/zh
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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CN202280042815.9A 2021-04-17 2022-04-15 Dna依赖性蛋白质激酶抑制剂以及其组合物和用途 Pending CN117940426A (zh)

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US202163176225P 2021-04-17 2021-04-17
US63/176,225 2021-04-17
PCT/US2022/025075 WO2022221696A1 (en) 2021-04-17 2022-04-15 Inhibitors of dna-dependent protein kinase and compositions and uses thereof

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EP (1) EP4323360A1 (enExample)
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CL2023003079A1 (es) 2024-04-12
CO2023015478A2 (es) 2025-07-07

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