JP2024507451A5 - - Google Patents

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Publication number
JP2024507451A5
JP2024507451A5 JP2023546555A JP2023546555A JP2024507451A5 JP 2024507451 A5 JP2024507451 A5 JP 2024507451A5 JP 2023546555 A JP2023546555 A JP 2023546555A JP 2023546555 A JP2023546555 A JP 2023546555A JP 2024507451 A5 JP2024507451 A5 JP 2024507451A5
Authority
JP
Japan
Prior art keywords
cas
fusion protein
linker
domain
repressor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023546555A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024507451A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/015162 external-priority patent/WO2022170007A1/en
Publication of JP2024507451A publication Critical patent/JP2024507451A/ja
Publication of JP2024507451A5 publication Critical patent/JP2024507451A5/ja
Pending legal-status Critical Current

Links

JP2023546555A 2021-02-05 2022-02-04 Crisprに基づく転写抑制用融合タンパク質 Pending JP2024507451A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163146419P 2021-02-05 2021-02-05
US63/146,419 2021-02-05
PCT/US2022/015162 WO2022170007A1 (en) 2021-02-05 2022-02-04 Fusion proteins for crispr-based transcriptional repression

Publications (2)

Publication Number Publication Date
JP2024507451A JP2024507451A (ja) 2024-02-20
JP2024507451A5 true JP2024507451A5 (https=) 2025-02-10

Family

ID=82741783

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023546555A Pending JP2024507451A (ja) 2021-02-05 2022-02-04 Crisprに基づく転写抑制用融合タンパク質

Country Status (6)

Country Link
US (1) US20240309347A1 (https=)
EP (1) EP4288548A4 (https=)
JP (1) JP2024507451A (https=)
CN (1) CN117062912A (https=)
CA (1) CA3210492A1 (https=)
WO (1) WO2022170007A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024230979A1 (en) * 2023-03-06 2025-10-16 Nchroma Bio, Inc. Compositions and methods for epigenetic regulation of pcsk9 expression

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007284651B2 (en) * 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
CA2732138A1 (en) * 2008-07-28 2010-02-04 Forbes Oil And Gas Pty Ltd Method of liquefaction of carbonaceous material to liquid hydrocarbon
DK2931891T3 (da) * 2012-12-17 2019-08-19 Harvard College Rna-styret modificering af menneskelige genomer
WO2016094872A1 (en) * 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
WO2016138340A1 (en) * 2015-02-27 2016-09-01 Saint Louis University Tumor suppressor sall1 as a therapeutic agent for treating cancer
US11629342B2 (en) * 2017-10-17 2023-04-18 President And Fellows Of Harvard College Cas9-based transcription modulation systems
US11957695B2 (en) * 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
JP2022511390A (ja) * 2018-11-20 2022-01-31 ユニバーシティ オブ ワシントン 分割インターロイキン模倣体およびその使用

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