JP2024507451A - Ｃｒｉｓｐｒに基づく転写抑制用融合タンパク質 - Google Patents

Ｃｒｉｓｐｒに基づく転写抑制用融合タンパク質 Download PDF

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JP2024507451A
JP2024507451A JP2023546555A JP2023546555A JP2024507451A JP 2024507451 A JP2024507451 A JP 2024507451A JP 2023546555 A JP2023546555 A JP 2023546555A JP 2023546555 A JP2023546555 A JP 2023546555A JP 2024507451 A JP2024507451 A JP 2024507451A
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cas
protein
fusion protein
linker
repression domain
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JP2024507451A5 (https=
Inventor
マイルス，クラレンス
シエル，ジョン
ストレゾスカ，ザクリーナ
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Dharmacon Inc
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Dharmacon Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2023546555A 2021-02-05 2022-02-04 Ｃｒｉｓｐｒに基づく転写抑制用融合タンパク質 Pending JP2024507451A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163146419P 2021-02-05 2021-02-05
US63/146,419 2021-02-05
PCT/US2022/015162 WO2022170007A1 (en) 2021-02-05 2022-02-04 Fusion proteins for crispr-based transcriptional repression

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JP2024507451A true JP2024507451A (ja) 2024-02-20
JP2024507451A5 JP2024507451A5 (https=) 2025-02-10

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US (1) US20240309347A1 (https=)
EP (1) EP4288548A4 (https=)
JP (1) JP2024507451A (https=)
CN (1) CN117062912A (https=)
CA (1) CA3210492A1 (https=)
WO (1) WO2022170007A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024230979A1 (en) * 2023-03-06 2025-10-16 Nchroma Bio, Inc. Compositions and methods for epigenetic regulation of pcsk9 expression

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170321214A1 (en) * 2014-12-12 2017-11-09 The Broad Institute Inc. Dead guides for crispr transcription factors
WO2019079462A1 (en) * 2017-10-17 2019-04-25 President And Fellows Of Harvard College TRANSCRIPTION MODULATION SYSTEMS BASED ON CAS9

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007284651B2 (en) * 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
CA2732138A1 (en) * 2008-07-28 2010-02-04 Forbes Oil And Gas Pty Ltd Method of liquefaction of carbonaceous material to liquid hydrocarbon
DK2931891T3 (da) * 2012-12-17 2019-08-19 Harvard College Rna-styret modificering af menneskelige genomer
WO2016138340A1 (en) * 2015-02-27 2016-09-01 Saint Louis University Tumor suppressor sall1 as a therapeutic agent for treating cancer
US11957695B2 (en) * 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
JP2022511390A (ja) * 2018-11-20 2022-01-31 ユニバーシティ オブ ワシントン 分割インターロイキン模倣体およびその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170321214A1 (en) * 2014-12-12 2017-11-09 The Broad Institute Inc. Dead guides for crispr transcription factors
WO2019079462A1 (en) * 2017-10-17 2019-04-25 President And Fellows Of Harvard College TRANSCRIPTION MODULATION SYSTEMS BASED ON CAS9

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CN117062912A (zh) 2023-11-14
US20240309347A1 (en) 2024-09-19
WO2022170007A1 (en) 2022-08-11
EP4288548A1 (en) 2023-12-13
EP4288548A4 (en) 2025-01-15
CA3210492A1 (en) 2022-08-11

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