JP2024505250A5 - - Google Patents
Info
- Publication number
- JP2024505250A5 JP2024505250A5 JP2023546234A JP2023546234A JP2024505250A5 JP 2024505250 A5 JP2024505250 A5 JP 2024505250A5 JP 2023546234 A JP2023546234 A JP 2023546234A JP 2023546234 A JP2023546234 A JP 2023546234A JP 2024505250 A5 JP2024505250 A5 JP 2024505250A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163143025P | 2021-01-28 | 2021-01-28 | |
| US63/143,025 | 2021-01-28 | ||
| US202163183612P | 2021-05-03 | 2021-05-03 | |
| US63/183,612 | 2021-05-03 | ||
| US202163274893P | 2021-11-02 | 2021-11-02 | |
| US63/274,893 | 2021-11-02 | ||
| PCT/US2022/014156 WO2022165076A1 (en) | 2021-01-28 | 2022-01-27 | Gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024505250A JP2024505250A (ja) | 2024-02-05 |
| JP2024505250A5 true JP2024505250A5 (enExample) | 2025-01-31 |
Family
ID=80447497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023546234A Pending JP2024505250A (ja) | 2021-01-28 | 2022-01-27 | Ｇｐｃｒ受容体アゴニスト、それを含む医薬組成物、及びそれらの使用方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20230089073A1 (enExample) |
| EP (2) | EP4563199A3 (enExample) |
| JP (1) | JP2024505250A (enExample) |
| KR (1) | KR20230152011A (enExample) |
| AU (1) | AU2022212019A1 (enExample) |
| BR (1) | BR112023015045A2 (enExample) |
| CA (1) | CA3209593A1 (enExample) |
| CL (2) | CL2023002204A1 (enExample) |
| CO (1) | CO2023011071A2 (enExample) |
| CR (1) | CR20230330A (enExample) |
| EC (1) | ECSP23057029A (enExample) |
| GE (1) | GEAP202316333A (enExample) |
| IL (1) | IL304521A (enExample) |
| JO (1) | JOP20230167A1 (enExample) |
| MX (1) | MX2023008854A (enExample) |
| PE (1) | PE20231814A1 (enExample) |
| WO (1) | WO2022165076A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202206429A (zh) | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| JP2023537501A (ja) | 2020-08-06 | 2023-09-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| EP4204415A4 (en) * | 2020-08-28 | 2025-03-26 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| WO2023029380A1 (zh) * | 2021-08-30 | 2023-03-09 | 杭州德睿智药科技有限公司 | 作为glp1r激动剂的新型芳醚取代杂环类化合物 |
| PT4408840T (pt) | 2021-09-27 | 2025-10-07 | Terns Pharmaceuticals Inc | Ácidos benzimidazolocarboxílicos como agonistas de glp-1r |
| WO2023057414A1 (en) | 2021-10-05 | 2023-04-13 | Astrazeneca Ab | Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators |
| US20250115612A1 (en) | 2021-10-05 | 2025-04-10 | Astrazeneca Ab | Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines as glp-1 receptor modulators |
| MX2024004131A (es) | 2021-10-05 | 2024-04-22 | Astrazeneca Ab | Ciertos 2,5-diazabiciclo[4.2.0]octanos como moduladores del receptor de glp-1. |
| CN118401519A (zh) | 2021-10-25 | 2024-07-26 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| WO2023111144A1 (en) | 2021-12-16 | 2023-06-22 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| US20250042882A1 (en) | 2021-12-16 | 2025-02-06 | Astrazeneca Ab | Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators |
| CN119095843A (zh) | 2022-02-23 | 2024-12-06 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| CN117362282B (zh) * | 2022-07-07 | 2026-04-21 | 杭州德睿智药科技有限公司 | Glp-1r激动剂的盐及其制备方法和应用 |
| US20260028332A1 (en) * | 2022-07-18 | 2026-01-29 | Mindrank Therapeutics (Suzhou) New Drug Research And Development Co., Ltd | Polymorphic form of glp-1r agonist, preparation method therefor and use thereof |
| EP4562006A1 (en) * | 2022-07-27 | 2025-06-04 | Carmot Therapeutics, Inc. | N-heterocylic gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use |
| WO2024051700A1 (zh) * | 2022-09-05 | 2024-03-14 | 德睿智药(苏州)新药研发有限公司 | 作为glp1r激动剂的新型芳基氘代苄醚取代杂环类化合物 |
| MX2025002598A (es) * | 2022-09-06 | 2025-05-02 | Mindrank Therapeutics Suzhou New Drug Res And Development Co Ltd | Polimorfo de compuesto agonista de glp-1r, método de preparación para el mismo, y uso de este |
| CN116102543B (zh) * | 2022-10-21 | 2025-07-22 | 江南大学 | 一种glp-1r激动剂、合成方法及其用途 |
| WO2024102625A1 (en) | 2022-11-11 | 2024-05-16 | Eli Lilly And Company | Glucagon-like peptide 1 receptor agonists |
| KR20250085816A (ko) | 2022-11-16 | 2025-06-12 | 일라이 릴리 앤드 캄파니 | 글루카곤-유사 펩티드 1 수용체 효능제 |
| JP2026501286A (ja) * | 2022-12-22 | 2026-01-14 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| WO2024153041A1 (zh) * | 2023-01-19 | 2024-07-25 | 杭州德睿智药科技有限公司 | Glp-1r激动剂的制造方法与中间体及其用途 |
| EP4568664B1 (en) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity |
| CN120981457A (zh) | 2023-09-14 | 2025-11-18 | 歌礼制药(中国)有限公司 | Glp-1r激动剂及其治疗方法 |
| TW202521534A (zh) | 2023-11-24 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
| WO2025128564A1 (en) | 2023-12-11 | 2025-06-19 | Carmot Therapeutics, Inc. | Salt forms of a glp-1 receptor modulator |
| WO2025128561A1 (en) | 2023-12-11 | 2025-06-19 | Carmot Therapeutics, Inc. | Crystalline forms of a glp-1 receptor modulator |
| WO2025158275A1 (en) | 2024-01-24 | 2025-07-31 | Pfizer Inc. | Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds |
| TW202600132A (zh) | 2024-03-08 | 2026-01-01 | 美商安尼波那生物公司 | 用於治療肥胖症及提高減重之方法 |
| WO2025259888A1 (en) | 2024-06-13 | 2025-12-18 | Carmot Therapeutics Inc. | Method of treating diabetes using a glp-1 receptor agonist |
| WO2026047102A1 (en) | 2024-08-29 | 2026-03-05 | F. Hoffmann-La Roche Ag | Process for the preparation of pyrimidine derivatives |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2646755A1 (en) * | 2006-03-31 | 2007-10-11 | Astrazeneca Ab | Bicyclic benzimidazole compounds and their use as metabotropic glutamate receptor potentiators |
| MX2009005881A (es) * | 2006-12-13 | 2009-06-12 | Hoffmann La Roche | Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida. |
| KR102314286B1 (ko) * | 2016-12-16 | 2021-10-21 | 화이자 인코포레이티드 | Glp-1 수용체 작용제 및 이의 용도 |
| US10934279B2 (en) | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| MA54555A (fr) * | 2018-11-22 | 2021-09-29 | Qilu Regor Therapeutics Inc | Agonistes de glp-1r et leurs utilisations |
| EP3953344A4 (en) | 2019-04-12 | 2023-08-09 | Qilu Regor Therapeutics Inc. | GLP-IR AGONISTS AND THEIR USES |
| WO2020234726A1 (en) | 2019-05-20 | 2020-11-26 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
| TWI751585B (zh) | 2019-06-28 | 2022-01-01 | 美商美國禮來大藥廠 | 類升糖素肽1受體促效劑 |
| WO2021096284A1 (ko) * | 2019-11-15 | 2021-05-20 | 일동제약(주) | Glp-1 수용체 작용제 및 이의 용도 |
| TW202144340A (zh) * | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
| TW202206429A (zh) * | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| CA3192601A1 (en) * | 2020-08-21 | 2022-02-24 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| EP4204415A4 (en) * | 2020-08-28 | 2025-03-26 | Gasherbrum Bio, Inc. | HETEROCYCLIC GLP-1 AGONISTS |
| CA3188891A1 (en) * | 2020-09-01 | 2022-01-13 | Fanglong Yang | Fused imidazole derivative, preparation method therefor, and medical use thereof |
| WO2023029380A1 (zh) | 2021-08-30 | 2023-03-09 | 杭州德睿智药科技有限公司 | 作为glp1r激动剂的新型芳醚取代杂环类化合物 |
-
2022
- 2022-01-27 CR CR20230330A patent/CR20230330A/es unknown
- 2022-01-27 AU AU2022212019A patent/AU2022212019A1/en active Pending
- 2022-01-27 PE PE2023002212A patent/PE20231814A1/es unknown
- 2022-01-27 KR KR1020237029178A patent/KR20230152011A/ko active Pending
- 2022-01-27 GE GEAP202316333A patent/GEAP202316333A/en unknown
- 2022-01-27 EP EP25162106.6A patent/EP4563199A3/en active Pending
- 2022-01-27 US US17/586,751 patent/US20230089073A1/en not_active Abandoned
- 2022-01-27 US US18/262,956 patent/US20240252492A1/en not_active Abandoned
- 2022-01-27 JP JP2023546234A patent/JP2024505250A/ja active Pending
- 2022-01-27 MX MX2023008854A patent/MX2023008854A/es unknown
- 2022-01-27 EP EP22704219.9A patent/EP4284795A1/en active Pending
- 2022-01-27 WO PCT/US2022/014156 patent/WO2022165076A1/en not_active Ceased
- 2022-01-27 CA CA3209593A patent/CA3209593A1/en active Pending
- 2022-01-27 BR BR112023015045A patent/BR112023015045A2/pt unknown
-
2023
- 2023-07-17 IL IL304521A patent/IL304521A/en unknown
- 2023-07-26 JO JOJO/P/2023/0167A patent/JOP20230167A1/ar unknown
- 2023-07-26 CL CL2023002204A patent/CL2023002204A1/es unknown
- 2023-07-27 EC ECSENADI202357029A patent/ECSP23057029A/es unknown
- 2023-08-24 CO CONC2023/0011071A patent/CO2023011071A2/es unknown
-
2024
- 2024-04-11 US US18/632,736 patent/US20250092025A1/en not_active Abandoned
- 2024-08-08 CL CL2024002388A patent/CL2024002388A1/es unknown
-
2025
- 2025-01-14 US US19/020,628 patent/US12459929B2/en active Active
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