JP2024504505A5 - - Google Patents
Info
- Publication number
- JP2024504505A5 JP2024504505A5 JP2023546405A JP2023546405A JP2024504505A5 JP 2024504505 A5 JP2024504505 A5 JP 2024504505A5 JP 2023546405 A JP2023546405 A JP 2023546405A JP 2023546405 A JP2023546405 A JP 2023546405A JP 2024504505 A5 JP2024504505 A5 JP 2024504505A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- item
- formula
- strand
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163143805P | 2021-01-30 | 2021-01-30 | |
| US63/143,805 | 2021-01-30 | ||
| US202163262311P | 2021-10-08 | 2021-10-08 | |
| US63/262,311 | 2021-10-08 | ||
| US202163271686P | 2021-10-25 | 2021-10-25 | |
| US63/271,686 | 2021-10-25 | ||
| PCT/EP2022/052067 WO2022162153A1 (en) | 2021-01-30 | 2022-01-28 | Conjugated oligonucleotide compounds, methods of making and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024504505A JP2024504505A (ja) | 2024-01-31 |
| JP2024504505A5 true JP2024504505A5 (https=) | 2025-01-27 |
Family
ID=80446096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023546405A Pending JP2024504505A (ja) | 2021-01-30 | 2022-01-28 | コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12338438B2 (https=) |
| EP (2) | EP4175965B1 (https=) |
| JP (1) | JP2024504505A (https=) |
| AU (1) | AU2022214281B2 (https=) |
| CA (1) | CA3204340A1 (https=) |
| ES (1) | ES2977721T3 (https=) |
| WO (1) | WO2022162153A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3204340A1 (en) | 2021-01-30 | 2022-08-04 | Ahmad Ali MORTAZAVI | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| WO2023059948A1 (en) * | 2021-10-08 | 2023-04-13 | E-Therapeutics Plc | Nucleic acids containing abasic nucleosides |
| CN120615125A (zh) * | 2022-07-27 | 2025-09-09 | e-生物有限公司 | 核酸化合物 |
| CN120322552A (zh) * | 2022-07-27 | 2025-07-15 | e-生物有限公司 | 核酸化合物 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8273866B2 (en) | 2002-02-20 | 2012-09-25 | Merck Sharp & Dohme Corp. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
| DE60310944T3 (de) | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Weitere neue formen von interferierende rns moleküle |
| US9150606B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2'-modified nucleosides for use in gene modulation |
| US9150605B2 (en) | 2002-11-05 | 2015-10-06 | Isis Pharmaceuticals, Inc. | Compositions comprising alternating 2′-modified nucleosides for use in gene modulation |
| KR100576357B1 (ko) | 2003-10-21 | 2006-05-03 | 삼성전자주식회사 | 레졸을 함유하는 수지용액, 이를 사용하여 형성된열경화수지막 및 이를 사용하여 열경화수지막을 형성하는방법 |
| WO2009073809A2 (en) * | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| AU2009298802A1 (en) * | 2008-09-23 | 2010-04-08 | Alnylam Pharmaceuticals, Inc. | Chemical modifications of monomers and oligonucleotides with cycloaddition |
| DK2992098T3 (da) * | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3564374A1 (en) | 2013-06-21 | 2019-11-06 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulation of target nucleic acids |
| WO2015042447A1 (en) * | 2013-09-20 | 2015-03-26 | Isis Pharmaceuticals, Inc. | Targeted therapeutic nucleosides and their use |
| US10119136B2 (en) | 2014-01-09 | 2018-11-06 | Alnylam Pharmaceuticals, Inc. | RNAi agents modified at the 4′-C position |
| WO2018013525A1 (en) * | 2016-07-11 | 2018-01-18 | Translate Bio Ma, Inc. | Nucleic acid conjugates and uses thereof |
| US11504391B1 (en) | 2016-11-23 | 2022-11-22 | Alnylam Pharmaceuticals, Inc. | Modified RNA agents with reduced off-target effect |
| TWI788312B (zh) | 2016-11-23 | 2023-01-01 | 美商阿尼拉製藥公司 | 絲胺酸蛋白酶抑制因子Ａ１ ｉＲＮＡ組成物及其使用方法 |
| WO2018112320A1 (en) | 2016-12-16 | 2018-06-21 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions |
| CN110268060B (zh) | 2017-01-10 | 2024-07-26 | 箭头药业股份有限公司 | α-1抗胰蛋白酶(AAT)RNAi物质、包含AAT RNAi物质的组合物和使用方法 |
| AU2018213379A1 (en) | 2017-01-30 | 2019-07-18 | Arrowhead Pharmaceuticals Inc. | Compositions and methods for inhibition of factor XII gene expression |
| EA202090720A1 (ru) | 2017-09-14 | 2020-07-07 | Янссен Байофарма, Инк. | ПРОИЗВОДНЫЕ GalNAc |
| PE20211783A1 (es) * | 2018-11-08 | 2021-09-08 | Aligos Therapeutics Inc | Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos |
| EP3931323A4 (en) * | 2019-02-28 | 2023-04-05 | Deep Genomics Incorporated | LIGAND CLUSTER AND METHODS OF USE AND PRODUCTION THEREOF |
| EP3976788A1 (en) | 2019-05-30 | 2022-04-06 | Deep Genomics Incorporated | Oligonucleotide therapy for wolman disease and cholesteryl ester storage disease |
| WO2021261992A1 (en) * | 2020-06-24 | 2021-12-30 | Sapreme Technologies B.V. | Conjugate of galnac and saponin, therapeutic composition comprising said conjugate and a galnac-oligonucleotide conjugate |
| AU2022212580A1 (en) | 2021-01-30 | 2023-07-27 | E-Therapeutics Plc | Nucleic acids containing abasic nucleotides |
| JP2024504504A (ja) | 2021-01-30 | 2024-01-31 | イー セラピューティクス パブリック リミテッド カンパニー | コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 |
| EP4176061A1 (en) * | 2021-01-30 | 2023-05-10 | E-Therapeutics plc | Nucleic acids containing abasic nucleotides |
| CA3204340A1 (en) | 2021-01-30 | 2022-08-04 | Ahmad Ali MORTAZAVI | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| CN120225673A (zh) | 2022-06-01 | 2025-06-27 | e-生物有限公司 | 表达和/或功能抑制剂 |
-
2022
- 2022-01-28 CA CA3204340A patent/CA3204340A1/en active Pending
- 2022-01-28 JP JP2023546405A patent/JP2024504505A/ja active Pending
- 2022-01-28 WO PCT/EP2022/052067 patent/WO2022162153A1/en not_active Ceased
- 2022-01-28 EP EP22704881.6A patent/EP4175965B1/en active Active
- 2022-01-28 ES ES22704881T patent/ES2977721T3/es active Active
- 2022-01-28 EP EP24160680.5A patent/EP4357334A3/en active Pending
- 2022-01-28 AU AU2022214281A patent/AU2022214281B2/en active Active
-
2023
- 2023-02-06 US US18/106,149 patent/US12338438B2/en active Active
-
2025
- 2025-05-16 US US19/211,026 patent/US20260085314A1/en active Pending
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