JP2024504505A - コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 - Google Patents

コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 Download PDF

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JP2024504505A
JP2024504505A JP2023546405A JP2023546405A JP2024504505A JP 2024504505 A JP2024504505 A JP 2024504505A JP 2023546405 A JP2023546405 A JP 2023546405A JP 2023546405 A JP2023546405 A JP 2023546405A JP 2024504505 A JP2024504505 A JP 2024504505A
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アリ モルタザヴィ、アフマド
マンネラ、ヴィヴィアナ
ジャヤラマン、ムトゥサミー
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イー セラピューティクス パブリック リミテッド カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised

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  • Animal Behavior & Ethology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2023546405A 2021-01-30 2022-01-28 コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 Pending JP2024504505A (ja)

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Application Number Priority Date Filing Date Title
US202163143805P 2021-01-30 2021-01-30
US63/143,805 2021-01-30
US202163262311P 2021-10-08 2021-10-08
US63/262,311 2021-10-08
US202163271686P 2021-10-25 2021-10-25
US63/271,686 2021-10-25
PCT/EP2022/052067 WO2022162153A1 (en) 2021-01-30 2022-01-28 Conjugated oligonucleotide compounds, methods of making and uses thereof

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US (2) US12338438B2 (https=)
EP (2) EP4175965B1 (https=)
JP (1) JP2024504505A (https=)
AU (1) AU2022214281B2 (https=)
CA (1) CA3204340A1 (https=)
ES (1) ES2977721T3 (https=)
WO (1) WO2022162153A1 (https=)

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CA3204340A1 (en) 2021-01-30 2022-08-04 Ahmad Ali MORTAZAVI Conjugated oligonucleotide compounds, methods of making and uses thereof
WO2023059948A1 (en) * 2021-10-08 2023-04-13 E-Therapeutics Plc Nucleic acids containing abasic nucleosides
CN120615125A (zh) * 2022-07-27 2025-09-09 e-生物有限公司 核酸化合物
CN120322552A (zh) * 2022-07-27 2025-07-15 e-生物有限公司 核酸化合物

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WO2022162155A1 (en) * 2021-01-30 2022-08-04 E-Therapeutics Plc Nucleic acids containing abasic nucleotides

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EP4357334A3 (en) 2024-08-07
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US20260085314A1 (en) 2026-03-26
AU2022214281B2 (en) 2026-04-09
ES2977721T3 (es) 2024-08-29
US12338438B2 (en) 2025-06-24
AU2022214281A1 (en) 2023-07-27
EP4175965A1 (en) 2023-05-10
CA3204340A1 (en) 2022-08-04
WO2022162153A1 (en) 2022-08-04
EP4357334A2 (en) 2024-04-24
EP4357334A9 (en) 2024-06-19

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