JP2024155943A5 - - Google Patents

Info

Publication number

JP2024155943A5

JP2024155943A5 JP2024134780A JP2024134780A JP2024155943A5 JP 2024155943 A5 JP2024155943 A5 JP 2024155943A5 JP 2024134780 A JP2024134780 A JP 2024134780A JP 2024134780 A JP2024134780 A JP 2024134780A JP 2024155943 A5 JP2024155943 A5 JP 2024155943A5

Authority

JP

Japan

Prior art keywords

cell

polypeptide

region

cancer

antigen

Prior art date

2024-08-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims 19
• 229920001184 polypeptide Polymers 0.000 claims 14
• 102000004196 processed proteins & peptides Human genes 0.000 claims 14
• 206010028980 Neoplasm Diseases 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 9
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 8
• 239000000427 antigen Substances 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 125000006850 spacer group Chemical group 0.000 claims 5
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 4
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 4
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
• 210000001744 T-lymphocyte Anatomy 0.000 claims 3
• 230000000139 costimulatory effect Effects 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 208000003174 Brain Neoplasms Diseases 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 108700012439 CA9 Proteins 0.000 claims 2
• -1 CD44v7/8 Proteins 0.000 claims 2
• 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 2
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 2
• 108010009685 Cholinergic Receptors Proteins 0.000 claims 2
• 101150029707 ERBB2 gene Proteins 0.000 claims 2
• 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims 2
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
• 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims 2
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
• 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
• 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 2
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 2
• 102000003735 Mesothelin Human genes 0.000 claims 2
• 108090000015 Mesothelin Proteins 0.000 claims 2
• 102100034256 Mucin-1 Human genes 0.000 claims 2
• 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
• 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 2
• 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims 2
• 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 2
• 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 2
• 102000034337 acetylcholine receptors Human genes 0.000 claims 2
• 210000003719 b-lymphocyte Anatomy 0.000 claims 2
• 230000001605 fetal effect Effects 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 230000036210 malignancy Effects 0.000 claims 2
• 201000001441 melanoma Diseases 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 2
• 101150047061 tag-72 gene Proteins 0.000 claims 2
• 230000004913 activation Effects 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 210000004475 gamma-delta t lymphocyte Anatomy 0.000 claims 1
• 210000002865 immune cell Anatomy 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 210000003289 regulatory T cell Anatomy 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 230000000638 stimulation Effects 0.000 claims 1