CN108884155B - 转化生长因子-β应答多肽及其使用方法 - Google Patents

转化生长因子-β应答多肽及其使用方法 Download PDF

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CN108884155B
CN108884155B CN201680077053.0A CN201680077053A CN108884155B CN 108884155 B CN108884155 B CN 108884155B CN 201680077053 A CN201680077053 A CN 201680077053A CN 108884155 B CN108884155 B CN 108884155B
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tgf
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CN108884155A (zh
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伊冯娜·于-轩·陈
常泽南利
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University of California San Diego UCSD
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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CN201680077053.0A 2015-10-30 2016-10-28 转化生长因子-β应答多肽及其使用方法 Active CN108884155B (zh)

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US11253546B2 (en) 2014-12-15 2022-02-22 The Regents Of The University Of California Bispecific OR-gate chimeric antigen receptor responsive to CD19 and CD20
EP3368571B1 (en) * 2015-10-30 2022-12-07 The Regents of The University of California Transforming growth factor-beta-responsive polypeptides and their methods for use
KR20180131557A (ko) * 2016-04-05 2018-12-10 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 면역요법에서의 tgf베타의 억제
KR20190057308A (ko) 2016-09-02 2019-05-28 더 리전츠 오브 더 유니버시티 오브 캘리포니아 인터류킨-6 수용체 알파-결합 단일 사슬 가변 단편을 포함하는 방법 및 조성물
US20200121726A1 (en) * 2017-06-30 2020-04-23 Kolon Life Science, Inc. Pharmaceutical composition for preventing or treating osteoarthritis
CN109486745A (zh) * 2017-09-12 2019-03-19 中国人民解放军第三军医大学第附属医院 Fg-4592在促进表皮干细胞迁移方面的应用
ES2960686T3 (es) * 2018-01-19 2024-03-06 Miltenyi Biotec Bv & Co Kg Células T reguladoras que expresan un receptor de antígeno quimérico
GB201807693D0 (en) * 2018-05-11 2018-06-27 Autolus Ltd Cell
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
US20210061881A1 (en) * 2019-08-30 2021-03-04 Allogene Therapeutics, Inc. Chimeric cytokine receptors comprising tgf beta binding domains
CN111748043B (zh) * 2020-07-03 2022-09-02 深圳市体内生物医药科技有限公司 一种嵌合抗原受体及其应用
EP4204443A4 (en) * 2020-08-26 2025-02-26 The Regents of The University of California METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLIOBLASTOMA
CN112500491B (zh) * 2020-12-18 2022-04-08 深圳市迈加瑞生物技术有限公司 一种特异性中和辅助性T细胞TGF-β信号的双特异性抗体、其药物组合及其用途
WO2023023602A1 (en) * 2021-08-19 2023-02-23 Boan Boston Llc Fusion proteins for dephosphorylating proteins that regulate t cell activation through the tcr signaling pathway
US20250250329A1 (en) * 2022-04-11 2025-08-07 The Board Of Trustees Of The Leland Stanford Junior University Cytokine adaptor proteins and uses thereof
EP4509522A1 (en) 2023-08-16 2025-02-19 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft A tgfbeta switch receptor, a nucleic acid encoding it, cells and pharmaceutical compositions comprising the same
WO2025096419A1 (en) * 2023-10-31 2025-05-08 Lyell Immunopharma, Inc. T cells comprising a chimeric antigen receptor targeting transforming growth factor beta and a t cell receptor targeting a tumor antigen, and use thereof

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