JP2024153768A5 - - Google Patents
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- JP2024153768A5 JP2024153768A5 JP2024121246A JP2024121246A JP2024153768A5 JP 2024153768 A5 JP2024153768 A5 JP 2024153768A5 JP 2024121246 A JP2024121246 A JP 2024121246A JP 2024121246 A JP2024121246 A JP 2024121246A JP 2024153768 A5 JP2024153768 A5 JP 2024153768A5
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- Prior art keywords
- cells
- amount
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- pharyngeal
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004039 endoderm cell Anatomy 0.000 claims 45
- 238000000034 method Methods 0.000 claims 43
- 210000004027 cell Anatomy 0.000 claims 28
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 26
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 26
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 26
- 210000003386 epithelial cell of thymus gland Anatomy 0.000 claims 24
- 238000012258 culturing Methods 0.000 claims 18
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 18
- 210000001541 thymus gland Anatomy 0.000 claims 17
- 230000004069 differentiation Effects 0.000 claims 16
- 210000002438 upper gastrointestinal tract Anatomy 0.000 claims 16
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 14
- 229930002330 retinoic acid Natural products 0.000 claims 14
- 229960001727 tretinoin Drugs 0.000 claims 14
- 206010034832 Pharyngeal pouch Diseases 0.000 claims 12
- 102000045246 noggin Human genes 0.000 claims 12
- 108700007229 noggin Proteins 0.000 claims 12
- 102100039541 Homeobox protein Hox-A3 Human genes 0.000 claims 8
- 101000962622 Homo sapiens Homeobox protein Hox-A3 Proteins 0.000 claims 8
- 101000713590 Homo sapiens T-box transcription factor TBX1 Proteins 0.000 claims 8
- 229940096116 Survivin inhibitor Drugs 0.000 claims 8
- 102100036771 T-box transcription factor TBX1 Human genes 0.000 claims 8
- 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 claims 6
- 241000282898 Sus scrofa Species 0.000 claims 6
- 108010023082 activin A Proteins 0.000 claims 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 5
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 5
- 230000002992 thymic effect Effects 0.000 claims 5
- 102000003693 Hedgehog Proteins Human genes 0.000 claims 4
- 108090000031 Hedgehog Proteins Proteins 0.000 claims 4
- 101000613575 Homo sapiens Paired box protein Pax-1 Proteins 0.000 claims 4
- 101000735484 Homo sapiens Paired box protein Pax-9 Proteins 0.000 claims 4
- 102100040851 Paired box protein Pax-1 Human genes 0.000 claims 4
- 102100034901 Paired box protein Pax-9 Human genes 0.000 claims 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 4
- XHBVYDAKJHETMP-UHFFFAOYSA-N dorsomorphin Chemical compound C=1C=C(C2=CN3N=CC(=C3N=C2)C=2C=CN=CC=2)C=CC=1OCCN1CCCCC1 XHBVYDAKJHETMP-UHFFFAOYSA-N 0.000 claims 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 210000002919 epithelial cell Anatomy 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000011712 cell development Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 1
- 244000309715 mini pig Species 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962827383P | 2019-04-01 | 2019-04-01 | |
| US62/827,383 | 2019-04-01 | ||
| PCT/US2020/025955 WO2020205859A1 (en) | 2019-04-01 | 2020-03-31 | Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells |
| JP2021558816A JP7740706B2 (ja) | 2019-04-01 | 2020-03-31 | 多能性幹細胞の胸腺上皮細胞および胸腺上皮前駆細胞分化を促進する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021558816A Division JP7740706B2 (ja) | 2019-04-01 | 2020-03-31 | 多能性幹細胞の胸腺上皮細胞および胸腺上皮前駆細胞分化を促進する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024153768A JP2024153768A (ja) | 2024-10-29 |
| JP2024153768A5 true JP2024153768A5 (enExample) | 2025-01-09 |
Family
ID=72667458
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021558816A Active JP7740706B2 (ja) | 2019-04-01 | 2020-03-31 | 多能性幹細胞の胸腺上皮細胞および胸腺上皮前駆細胞分化を促進する方法 |
| JP2024121246A Pending JP2024153768A (ja) | 2019-04-01 | 2024-07-26 | 多能性幹細胞の胸腺上皮細胞および胸腺上皮前駆細胞分化を促進する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021558816A Active JP7740706B2 (ja) | 2019-04-01 | 2020-03-31 | 多能性幹細胞の胸腺上皮細胞および胸腺上皮前駆細胞分化を促進する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220127569A1 (enExample) |
| EP (1) | EP3947639A4 (enExample) |
| JP (2) | JP7740706B2 (enExample) |
| KR (1) | KR20210146297A (enExample) |
| CN (2) | CN119351306A (enExample) |
| AU (1) | AU2020253429A1 (enExample) |
| CA (1) | CA3135377A1 (enExample) |
| IL (1) | IL286936A (enExample) |
| MX (1) | MX2021012041A (enExample) |
| SG (1) | SG11202109279PA (enExample) |
| WO (1) | WO2020205859A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115461446A (zh) * | 2020-04-28 | 2022-12-09 | 加利福尼亚大学董事会 | 用于在体外生成胸腺细胞的方法 |
| US20240076618A1 (en) * | 2021-01-15 | 2024-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Generation of induced human thymic epithelial cells and its application in cell-based immunotherapies |
| CN113215081B (zh) * | 2021-06-01 | 2023-04-14 | 华中科技大学同济医学院附属同济医院 | 诱导干细胞分化为甲状旁腺细胞的方法及其组合物 |
| JP2024536496A (ja) * | 2021-10-15 | 2024-10-04 | サイミューン セラピューティクス インコーポレイテッド | 胸腺細胞及びその製造方法 |
| EP4293110A1 (en) | 2022-06-17 | 2023-12-20 | Nantes Université | Process for obtaining functional lymphocytes cells |
| WO2025136749A1 (en) * | 2023-12-19 | 2025-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Thymic epithelial cells and methods of producing and using the same |
| CN119614476A (zh) * | 2024-11-13 | 2025-03-14 | 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） | 胸腺类器官的构建方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1363994A2 (en) | 2000-12-22 | 2003-11-26 | University Of Edinburgh | Thymic epithelial progenitor cells and uses thereof |
| JPWO2010143529A1 (ja) * | 2009-06-09 | 2012-11-22 | 国立大学法人名古屋大学 | 多能性幹細胞を胸腺上皮へ分化誘導する方法 |
| EP2563908B1 (en) * | 2010-04-25 | 2019-01-09 | Icahn School of Medicine at Mount Sinai | Generation of anterior foregut endoderm from pluripotent cells |
| CN102732479B (zh) * | 2011-03-31 | 2014-08-27 | 北京大学 | 胸腺上皮前体细胞的制备方法及其专用培养基 |
| KR101590603B1 (ko) * | 2012-10-12 | 2016-02-01 | 서강대학교산학협력단 | 미분화 인간 유도만능줄기세포의 선택적 세포사멸 유도를 통한 테라토마 형성 억제 방법 |
| US9850465B2 (en) * | 2013-02-27 | 2017-12-26 | The Regents Of The University Of California | Generation of thymic epithelial progenitor cells in vitro |
| EP3684920A1 (en) | 2017-09-20 | 2020-07-29 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | In vitro generation of thymic organoid from human pluripotent stem cells |
| KR20220004126A (ko) * | 2019-04-26 | 2022-01-11 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 유도 다능성 줄기 세포로부터 생체내에서 기능적이고 환자-특이적인 흉선 조직의 생성 |
| KR20220113720A (ko) * | 2019-11-25 | 2022-08-16 | 앨리게니 싱어 리서치 인스티튜트 | 인간 전분화능 줄기 세포로부터 생체공학적으로 조작된 흉선 오가노이드 |
-
2020
- 2020-03-31 CA CA3135377A patent/CA3135377A1/en active Pending
- 2020-03-31 SG SG11202109279PA patent/SG11202109279PA/en unknown
- 2020-03-31 MX MX2021012041A patent/MX2021012041A/es unknown
- 2020-03-31 AU AU2020253429A patent/AU2020253429A1/en active Pending
- 2020-03-31 CN CN202411293215.7A patent/CN119351306A/zh active Pending
- 2020-03-31 CN CN202080021893.1A patent/CN113646423B/zh active Active
- 2020-03-31 JP JP2021558816A patent/JP7740706B2/ja active Active
- 2020-03-31 WO PCT/US2020/025955 patent/WO2020205859A1/en not_active Ceased
- 2020-03-31 KR KR1020217029911A patent/KR20210146297A/ko active Pending
- 2020-03-31 EP EP20783448.2A patent/EP3947639A4/en active Pending
-
2021
- 2021-10-03 IL IL286936A patent/IL286936A/en unknown
-
2022
- 2022-01-12 US US17/492,137 patent/US20220127569A1/en active Pending
-
2024
- 2024-07-26 JP JP2024121246A patent/JP2024153768A/ja active Pending
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