MX2021012041A - Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas. - Google Patents

Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas.

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Publication number
MX2021012041A
MX2021012041A MX2021012041A MX2021012041A MX2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A MX 2021012041 A MX2021012041 A MX 2021012041A
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MX
Mexico
Prior art keywords
thymic epithelial
epithelial cell
methods
pluripotent stem
stem cells
Prior art date
Application number
MX2021012041A
Other languages
English (en)
Inventor
Megan Sykes
Mohsen Khosravi-Maharlooei
Nichole Danzl
Pena Rafael Gras
Original Assignee
Univ Columbia
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Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of MX2021012041A publication Critical patent/MX2021012041A/es

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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Abstract

La presente divulgación proporciona métodos para promover la diferenciación de células madre pluripotentes en células epiteliales tímicas o progenitores de células epiteliales tímicas, así como las células obtenidas de los métodos y soluciones, composiciones y composiciones farmacéuticas que comprenden dichas células. La presente divulgación también proporciona métodos de uso de células epiteliales tímicas o progenitores de células epiteliales tímicas para el tratamiento y prevención de enfermedades, órganos generadores, así como otros usos y kits.
MX2021012041A 2019-04-01 2020-03-31 Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas. MX2021012041A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962827383P 2019-04-01 2019-04-01
PCT/US2020/025955 WO2020205859A1 (en) 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

Publications (1)

Publication Number Publication Date
MX2021012041A true MX2021012041A (es) 2021-11-03

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MX2021012041A MX2021012041A (es) 2019-04-01 2020-03-31 Metodos para promover la diferenciacion de celulas epiteliales timicas y progenitores de celulas epiteliales timicas de celulas madre pluripotentes, celulas resultantes y usos de estas.

Country Status (11)

Country Link
US (1) US20220127569A1 (es)
EP (1) EP3947639A4 (es)
JP (1) JP2022527338A (es)
KR (1) KR20210146297A (es)
CN (1) CN113646423A (es)
AU (1) AU2020253429A1 (es)
CA (1) CA3135377A1 (es)
IL (1) IL286936A (es)
MX (1) MX2021012041A (es)
SG (1) SG11202109279PA (es)
WO (1) WO2020205859A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022155291A1 (en) * 2021-01-15 2022-07-21 The Board Of Trustees Of The Leland Stanford Junior University Generation of induced human thymic epithelial cells and its application in cell-based immunotherapies
CN113215081B (zh) * 2021-06-01 2023-04-14 华中科技大学同济医学院附属同济医院 诱导干细胞分化为甲状旁腺细胞的方法及其组合物
WO2023064457A1 (en) * 2021-10-15 2023-04-20 Thymmune Therapeutics, Inc. Thymic cells and methods of making
EP4293110A1 (en) 2022-06-17 2023-12-20 Nantes Université Process for obtaining functional lymphocytes cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010143529A1 (ja) * 2009-06-09 2010-12-16 国立大学法人名古屋大学 多能性幹細胞を胸腺上皮へ分化誘導する方法
US9234170B2 (en) * 2010-04-25 2016-01-12 Mount Sinai School Of Medicine Generation of anterior foregut endoderm from pluripotent cells
CN102732479B (zh) * 2011-03-31 2014-08-27 北京大学 胸腺上皮前体细胞的制备方法及其专用培养基
WO2014058274A1 (ko) * 2012-10-12 2014-04-17 서강대학교 산학협력단 미분화 인간 유도만능줄기세포의 선택적 세포사멸 유도를 통한 테라토마 형성 억제 방법
CA3173076A1 (en) * 2013-02-27 2014-09-04 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
EP3684920A1 (en) * 2017-09-20 2020-07-29 The U.S.A. as represented by the Secretary, Department of Health and Human Services In vitro generation of thymic organoid from human pluripotent stem cells
KR20220004126A (ko) * 2019-04-26 2022-01-11 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 유도 다능성 줄기 세포로부터 생체내에서 기능적이고 환자-특이적인 흉선 조직의 생성
WO2021108514A1 (en) * 2019-11-25 2021-06-03 Allegheny Singer Research Institute Thymus organoids bioengineered form human pluripotent stem cells

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Publication number Publication date
WO2020205859A1 (en) 2020-10-08
SG11202109279PA (en) 2021-09-29
CA3135377A1 (en) 2020-10-08
AU2020253429A1 (en) 2021-09-09
IL286936A (en) 2021-10-31
CN113646423A (zh) 2021-11-12
EP3947639A4 (en) 2023-01-25
EP3947639A1 (en) 2022-02-09
US20220127569A1 (en) 2022-04-28
JP2022527338A (ja) 2022-06-01
KR20210146297A (ko) 2021-12-03

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