SG11202109279PA - Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells - Google Patents
Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cellsInfo
- Publication number
- SG11202109279PA SG11202109279PA SG11202109279PA SG11202109279PA SG11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA
- Authority
- SG
- Singapore
- Prior art keywords
- epithelial cell
- thymic epithelial
- methods
- stem cells
- pluripotent stem
- Prior art date
Links
- 210000003386 epithelial cell of thymus gland Anatomy 0.000 title 2
- 230000004069 differentiation Effects 0.000 title 1
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
- 230000001737 promoting effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/065—Thymocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962827383P | 2019-04-01 | 2019-04-01 | |
PCT/US2020/025955 WO2020205859A1 (en) | 2019-04-01 | 2020-03-31 | Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202109279PA true SG11202109279PA (en) | 2021-09-29 |
Family
ID=72667458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202109279PA SG11202109279PA (en) | 2019-04-01 | 2020-03-31 | Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220127569A1 (es) |
EP (1) | EP3947639A4 (es) |
JP (1) | JP2022527338A (es) |
KR (1) | KR20210146297A (es) |
CN (1) | CN113646423A (es) |
AU (1) | AU2020253429A1 (es) |
CA (1) | CA3135377A1 (es) |
IL (1) | IL286936A (es) |
MX (1) | MX2021012041A (es) |
SG (1) | SG11202109279PA (es) |
WO (1) | WO2020205859A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4277977A1 (en) * | 2021-01-15 | 2023-11-22 | The Board of Trustees of the Leland Stanford Junior University | Generation of induced human thymic epithelial cells and its application in cell-based immunotherapies |
CN113215081B (zh) * | 2021-06-01 | 2023-04-14 | 华中科技大学同济医学院附属同济医院 | 诱导干细胞分化为甲状旁腺细胞的方法及其组合物 |
CA3234507A1 (en) * | 2021-10-15 | 2023-04-20 | Bing Lim | Thymic cells and methods of making |
EP4293110A1 (en) | 2022-06-17 | 2023-12-20 | Nantes Université | Process for obtaining functional lymphocytes cells |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010143529A1 (ja) | 2009-06-09 | 2010-12-16 | 国立大学法人名古屋大学 | 多能性幹細胞を胸腺上皮へ分化誘導する方法 |
EP2563908B1 (en) * | 2010-04-25 | 2019-01-09 | Icahn School of Medicine at Mount Sinai | Generation of anterior foregut endoderm from pluripotent cells |
CN102732479B (zh) * | 2011-03-31 | 2014-08-27 | 北京大学 | 胸腺上皮前体细胞的制备方法及其专用培养基 |
US9657273B2 (en) * | 2012-10-12 | 2017-05-23 | Industry-University Cooperation Foundation Sogang University | Method for suppressing teratoma formation via selective cell death induction in undifferentiated human-induced pluripotent stem cells |
WO2014134213A1 (en) | 2013-02-27 | 2014-09-04 | The Regents Of The University Of California | Generation of thymic epithelial progenitor cells in vitro |
WO2019060336A1 (en) | 2017-09-20 | 2019-03-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | IN VITRO GENERATION OF THYMIC ORGANOID FROM HUMAN PLURIPOTENT STEM CELLS |
CN113767167A (zh) * | 2019-04-26 | 2021-12-07 | 科罗拉多大学董事会,法人 | 从诱导多能干细胞体内产生功能性和患者特异性胸腺组织 |
JP2023502522A (ja) * | 2019-11-25 | 2023-01-24 | アレゲーニー シンガー リサーチ インスティテュート | ヒト多能性幹細胞からバイオエンジニアリングされた胸腺オルガノイド |
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2020
- 2020-03-31 KR KR1020217029911A patent/KR20210146297A/ko unknown
- 2020-03-31 CN CN202080021893.1A patent/CN113646423A/zh active Pending
- 2020-03-31 JP JP2021558816A patent/JP2022527338A/ja active Pending
- 2020-03-31 WO PCT/US2020/025955 patent/WO2020205859A1/en unknown
- 2020-03-31 AU AU2020253429A patent/AU2020253429A1/en active Pending
- 2020-03-31 SG SG11202109279PA patent/SG11202109279PA/en unknown
- 2020-03-31 MX MX2021012041A patent/MX2021012041A/es unknown
- 2020-03-31 EP EP20783448.2A patent/EP3947639A4/en active Pending
- 2020-03-31 CA CA3135377A patent/CA3135377A1/en active Pending
-
2021
- 2021-10-03 IL IL286936A patent/IL286936A/en unknown
-
2022
- 2022-01-12 US US17/492,137 patent/US20220127569A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3947639A4 (en) | 2023-01-25 |
KR20210146297A (ko) | 2021-12-03 |
WO2020205859A1 (en) | 2020-10-08 |
CN113646423A (zh) | 2021-11-12 |
CA3135377A1 (en) | 2020-10-08 |
EP3947639A1 (en) | 2022-02-09 |
IL286936A (en) | 2021-10-31 |
US20220127569A1 (en) | 2022-04-28 |
MX2021012041A (es) | 2021-11-03 |
JP2022527338A (ja) | 2022-06-01 |
AU2020253429A1 (en) | 2021-09-09 |
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