SG11202109279PA - Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells - Google Patents

Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

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Publication number
SG11202109279PA
SG11202109279PA SG11202109279PA SG11202109279PA SG11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA
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Singapore
Prior art keywords
epithelial cell
thymic epithelial
methods
stem cells
pluripotent stem
Prior art date
Application number
SG11202109279PA
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English (en)
Inventor
Pena Rafael Gras
Megan Sykes
Nichole Danzl
Mohsen Khosravi-Maharlooei
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Univ Columbia
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Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Publication of SG11202109279PA publication Critical patent/SG11202109279PA/en

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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/065—Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
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    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
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SG11202109279PA 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells SG11202109279PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962827383P 2019-04-01 2019-04-01
PCT/US2020/025955 WO2020205859A1 (en) 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

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SG11202109279PA true SG11202109279PA (en) 2021-09-29

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US (1) US20220127569A1 (enExample)
EP (1) EP3947639A4 (enExample)
JP (2) JP7740706B2 (enExample)
KR (1) KR20210146297A (enExample)
CN (2) CN119351306A (enExample)
AU (1) AU2020253429A1 (enExample)
CA (1) CA3135377A1 (enExample)
IL (1) IL286936A (enExample)
MX (1) MX2021012041A (enExample)
SG (1) SG11202109279PA (enExample)
WO (1) WO2020205859A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115461446A (zh) * 2020-04-28 2022-12-09 加利福尼亚大学董事会 用于在体外生成胸腺细胞的方法
US20240076618A1 (en) * 2021-01-15 2024-03-07 The Board Of Trustees Of The Leland Stanford Junior University Generation of induced human thymic epithelial cells and its application in cell-based immunotherapies
CN113215081B (zh) * 2021-06-01 2023-04-14 华中科技大学同济医学院附属同济医院 诱导干细胞分化为甲状旁腺细胞的方法及其组合物
JP2024536496A (ja) * 2021-10-15 2024-10-04 サイミューン セラピューティクス インコーポレイテッド 胸腺細胞及びその製造方法
EP4293110A1 (en) 2022-06-17 2023-12-20 Nantes Université Process for obtaining functional lymphocytes cells
WO2025136749A1 (en) * 2023-12-19 2025-06-26 The Board Of Trustees Of The Leland Stanford Junior University Thymic epithelial cells and methods of producing and using the same
CN119614476A (zh) * 2024-11-13 2025-03-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 胸腺类器官的构建方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1363994A2 (en) 2000-12-22 2003-11-26 University Of Edinburgh Thymic epithelial progenitor cells and uses thereof
JPWO2010143529A1 (ja) * 2009-06-09 2012-11-22 国立大学法人名古屋大学 多能性幹細胞を胸腺上皮へ分化誘導する方法
EP2563908B1 (en) * 2010-04-25 2019-01-09 Icahn School of Medicine at Mount Sinai Generation of anterior foregut endoderm from pluripotent cells
CN102732479B (zh) * 2011-03-31 2014-08-27 北京大学 胸腺上皮前体细胞的制备方法及其专用培养基
KR101590603B1 (ko) * 2012-10-12 2016-02-01 서강대학교산학협력단 미분화 인간 유도만능줄기세포의 선택적 세포사멸 유도를 통한 테라토마 형성 억제 방법
US9850465B2 (en) * 2013-02-27 2017-12-26 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
EP3684920A1 (en) 2017-09-20 2020-07-29 The U.S.A. as represented by the Secretary, Department of Health and Human Services In vitro generation of thymic organoid from human pluripotent stem cells
KR20220004126A (ko) * 2019-04-26 2022-01-11 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 유도 다능성 줄기 세포로부터 생체내에서 기능적이고 환자-특이적인 흉선 조직의 생성
KR20220113720A (ko) * 2019-11-25 2022-08-16 앨리게니 싱어 리서치 인스티튜트 인간 전분화능 줄기 세포로부터 생체공학적으로 조작된 흉선 오가노이드

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CN113646423A (zh) 2021-11-12
CN113646423B (zh) 2024-10-01
IL286936A (en) 2021-10-31
JP2024153768A (ja) 2024-10-29
EP3947639A4 (en) 2023-01-25
EP3947639A1 (en) 2022-02-09
US20220127569A1 (en) 2022-04-28
WO2020205859A1 (en) 2020-10-08
KR20210146297A (ko) 2021-12-03
CA3135377A1 (en) 2020-10-08
AU2020253429A1 (en) 2021-09-09
CN119351306A (zh) 2025-01-24
JP2022527338A (ja) 2022-06-01
MX2021012041A (es) 2021-11-03
JP7740706B2 (ja) 2025-09-17

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