AU2020253429A1 - Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells - Google Patents

Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells Download PDF

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AU2020253429A1
AU2020253429A1 AU2020253429A AU2020253429A AU2020253429A1 AU 2020253429 A1 AU2020253429 A1 AU 2020253429A1 AU 2020253429 A AU2020253429 A AU 2020253429A AU 2020253429 A AU2020253429 A AU 2020253429A AU 2020253429 A1 AU2020253429 A1 AU 2020253429A1
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cells
thymic epithelial
pharyngeal
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Nichole DANZL
Rafael GRAS PENA
Mohsen KHOSRAVI-MAHARLOOEI
Megan Sykes
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Columbia University in the City of New York
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Columbia University in the City of New York
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AU2020253429A 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells Pending AU2020253429A1 (en)

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US201962827383P 2019-04-01 2019-04-01
US62/827,383 2019-04-01
PCT/US2020/025955 WO2020205859A1 (en) 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

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EP (1) EP3947639A4 (enExample)
JP (2) JP7740706B2 (enExample)
KR (1) KR20210146297A (enExample)
CN (2) CN113646423B (enExample)
AU (1) AU2020253429A1 (enExample)
CA (1) CA3135377A1 (enExample)
IL (1) IL286936A (enExample)
MX (1) MX2021012041A (enExample)
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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021262770A1 (en) * 2020-04-28 2022-11-17 The Regents Of The University Of California Methods for generating thymic cells in vitro
EP4277977A4 (en) * 2021-01-15 2025-02-12 The Board of Trustees of the Leland Stanford Junior University PRODUCTION OF INDUCED HUMAN THYMIC EPITHELIAL CELLS AND THEIR APPLICATION IN CELL-BASED IMMUNOTHERAPIES
CN113215081B (zh) * 2021-06-01 2023-04-14 华中科技大学同济医学院附属同济医院 诱导干细胞分化为甲状旁腺细胞的方法及其组合物
EP4416267A4 (en) * 2021-10-15 2025-10-08 Thymmune Therapeutics Inc THYMIC CELLS AND THEIR PROCESSES OF MANUFACTURE
EP4293110A1 (en) 2022-06-17 2023-12-20 Nantes Université Process for obtaining functional lymphocytes cells
WO2025136749A1 (en) * 2023-12-19 2025-06-26 The Board Of Trustees Of The Leland Stanford Junior University Thymic epithelial cells and methods of producing and using the same
CN119614476A (zh) * 2024-11-13 2025-03-14 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 胸腺类器官的构建方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156200A0 (en) 2000-12-22 2003-12-23 Univ Edinburgh Thymic epithelial progenitor cells and pharmaceutical compositions containing the same
JPWO2010143529A1 (ja) * 2009-06-09 2012-11-22 国立大学法人名古屋大学 多能性幹細胞を胸腺上皮へ分化誘導する方法
CN103068970A (zh) * 2010-04-25 2013-04-24 西奈山医学院 来自多能细胞的前部前肠内胚层的形成
CN102732479B (zh) * 2011-03-31 2014-08-27 北京大学 胸腺上皮前体细胞的制备方法及其专用培养基
US9657273B2 (en) * 2012-10-12 2017-05-23 Industry-University Cooperation Foundation Sogang University Method for suppressing teratoma formation via selective cell death induction in undifferentiated human-induced pluripotent stem cells
CA2902857C (en) 2013-02-27 2022-11-29 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
EP3684920A1 (en) 2017-09-20 2020-07-29 The U.S.A. as represented by the Secretary, Department of Health and Human Services In vitro generation of thymic organoid from human pluripotent stem cells
KR20220004126A (ko) * 2019-04-26 2022-01-11 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 유도 다능성 줄기 세포로부터 생체내에서 기능적이고 환자-특이적인 흉선 조직의 생성
WO2021108514A1 (en) * 2019-11-25 2021-06-03 Allegheny Singer Research Institute Thymus organoids bioengineered form human pluripotent stem cells

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CN119351306A (zh) 2025-01-24
KR20210146297A (ko) 2021-12-03
US20220127569A1 (en) 2022-04-28
MX2021012041A (es) 2021-11-03
CA3135377A1 (en) 2020-10-08
EP3947639A1 (en) 2022-02-09
JP2022527338A (ja) 2022-06-01
EP3947639A4 (en) 2023-01-25
JP2024153768A (ja) 2024-10-29
CN113646423A (zh) 2021-11-12
JP7740706B2 (ja) 2025-09-17
SG11202109279PA (en) 2021-09-29
WO2020205859A1 (en) 2020-10-08
CN113646423B (zh) 2024-10-01

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