JP2024099698A5 - - Google Patents

Info

Publication number

JP2024099698A5

JP2024099698A5 JP2024070181A JP2024070181A JP2024099698A5 JP 2024099698 A5 JP2024099698 A5 JP 2024099698A5 JP 2024070181 A JP2024070181 A JP 2024070181A JP 2024070181 A JP2024070181 A JP 2024070181A JP 2024099698 A5 JP2024099698 A5 JP 2024099698A5

Authority

JP

Japan

Prior art keywords

domain

amino acid

acid sequence

mammalian cell

seq

Prior art date

2024-04-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 24
• 210000004962 mammalian cell Anatomy 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 108020005004 Guide RNA Proteins 0.000 claims 6
• 230000001086 cytosolic effect Effects 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 239000013603 viral vector Substances 0.000 claims 6
• 230000011664 signaling Effects 0.000 claims 5
• 102000007260 Deoxyribonuclease I Human genes 0.000 claims 4
• 108010008532 Deoxyribonuclease I Proteins 0.000 claims 4
• 210000001744 T-lymphocyte Anatomy 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 102000018679 Tacrolimus Binding Proteins Human genes 0.000 claims 3
• 108010027179 Tacrolimus Binding Proteins Proteins 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000035475 disorder Diseases 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 229960002930 sirolimus Drugs 0.000 claims 3
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 3
• 102100027581 Forkhead box protein P3 Human genes 0.000 claims 2
• 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
• 210000003289 regulatory T cell Anatomy 0.000 claims 2
• BUROJSBIWGDYCN-GAUTUEMISA-N AP 23573 Chemical compound C1C[C@@H](OP(C)(C)=O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 BUROJSBIWGDYCN-GAUTUEMISA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 102100026234 Cytokine receptor common subunit gamma Human genes 0.000 claims 1
• 101710189311 Cytokine receptor common subunit gamma Proteins 0.000 claims 1
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
• 101150027879 FOXP3 gene Proteins 0.000 claims 1
• 102100026879 Interleukin-2 receptor subunit beta Human genes 0.000 claims 1
• 101710154942 Interleukin-2 receptor subunit beta Proteins 0.000 claims 1
• CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
• GQLCLPLEEOUJQC-ZTQDTCGGSA-N [(1r)-3-(3,4-dimethoxyphenyl)-1-[3-[2-[2-[[2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetyl]amino]ethylamino]-2-oxoethoxy]phenyl]propyl] (2s)-1-[(2s)-2-(3,4,5-trimethoxyph Chemical compound C([C@@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC)C=1C=C(OC)C(OC)=C(OC)C=1)C=1C=C(OCC(=O)NCCNC(=O)COC=2C=C(C=CC=2)[C@@H](CCC=2C=C(OC)C(OC)=CC=2)OC(=O)[C@H]2N(CCCC2)C(=O)[C@@H](CC)C=2C=C(OC)C(OC)=C(OC)C=2)C=CC=1)CC1=CC=C(OC)C(OC)=C1 GQLCLPLEEOUJQC-ZTQDTCGGSA-N 0.000 claims 1
• 229960004916 benidipine Drugs 0.000 claims 1
• QZVNQOLPLYWLHQ-ZEQKJWHPSA-N benidipine Chemical compound C1([C@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)O[C@H]2CN(CC=3C=CC=CC=3)CCC2)=CC=CC([N+]([O-])=O)=C1 QZVNQOLPLYWLHQ-ZEQKJWHPSA-N 0.000 claims 1
• MYMSKXFGXABEON-OYYFJIJNSA-N c-16-(s)-3-methylindolerapamycin Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](C=2C=3NC=C(C)C=3C=CC=2)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 MYMSKXFGXABEON-OYYFJIJNSA-N 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 229960005167 everolimus Drugs 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 229960000951 mycophenolic acid Drugs 0.000 claims 1
• HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
• 239000002105 nanoparticle Substances 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 229960000235 temsirolimus Drugs 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1
• 239000013598 vector Substances 0.000 claims 1