JP2024075687A5 - - Google Patents
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- JP2024075687A5 JP2024075687A5 JP2024044463A JP2024044463A JP2024075687A5 JP 2024075687 A5 JP2024075687 A5 JP 2024075687A5 JP 2024044463 A JP2024044463 A JP 2024044463A JP 2024044463 A JP2024044463 A JP 2024044463A JP 2024075687 A5 JP2024075687 A5 JP 2024075687A5
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- JP
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- Prior art keywords
- months
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- culture conditions
- population
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims 16
- 230000004069 differentiation Effects 0.000 claims 14
- 230000035755 proliferation Effects 0.000 claims 14
- 210000000465 brunner gland Anatomy 0.000 claims 8
- 210000001198 duodenum Anatomy 0.000 claims 8
- 239000002609 medium Substances 0.000 claims 8
- 210000002966 serum Anatomy 0.000 claims 8
- 239000012679 serum free medium Substances 0.000 claims 8
- 230000002440 hepatic effect Effects 0.000 claims 7
- 102100023974 Keratin, type II cytoskeletal 7 Human genes 0.000 claims 5
- 108010070507 Keratin-7 Proteins 0.000 claims 5
- 102100032912 CD44 antigen Human genes 0.000 claims 4
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 4
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 4
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 4
- 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 claims 4
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 4
- 101000711846 Homo sapiens Transcription factor SOX-9 Proteins 0.000 claims 4
- 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 claims 4
- 101150017554 LGR5 gene Proteins 0.000 claims 4
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 4
- 102100034204 Transcription factor SOX-9 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 101000652324 Homo sapiens Transcription factor SOX-17 Proteins 0.000 claims 2
- 101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 claims 2
- 102100035459 Pyruvate dehydrogenase protein X component, mitochondrial Human genes 0.000 claims 2
- 102100030243 Transcription factor SOX-17 Human genes 0.000 claims 2
- 230000009286 beneficial effect Effects 0.000 claims 2
- 244000005700 microbiome Species 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862650208P | 2018-03-29 | 2018-03-29 | |
| US62/650,208 | 2018-03-29 | ||
| JP2020552401A JP7562416B2 (ja) | 2018-03-29 | 2019-03-28 | 十二指腸ブルンナー腺由来の幹／前駆細胞ならびにそれらの単離および使用方法 |
| PCT/US2019/024543 WO2019191402A1 (en) | 2018-03-29 | 2019-03-28 | Stem/progenitor cells from duodenal brunner's glands and methods of isolating and using them |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020552401A Division JP7562416B2 (ja) | 2018-03-29 | 2019-03-28 | 十二指腸ブルンナー腺由来の幹／前駆細胞ならびにそれらの単離および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024075687A JP2024075687A (ja) | 2024-06-04 |
| JP2024075687A5 true JP2024075687A5 (enExample) | 2025-02-17 |
Family
ID=68054860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020552401A Active JP7562416B2 (ja) | 2018-03-29 | 2019-03-28 | 十二指腸ブルンナー腺由来の幹／前駆細胞ならびにそれらの単離および使用方法 |
| JP2024044463A Pending JP2024075687A (ja) | 2018-03-29 | 2024-03-21 | 十二指腸ブルンナー腺由来の幹／前駆細胞ならびにそれらの単離および使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020552401A Active JP7562416B2 (ja) | 2018-03-29 | 2019-03-28 | 十二指腸ブルンナー腺由来の幹／前駆細胞ならびにそれらの単離および使用方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20190300849A1 (enExample) |
| EP (1) | EP3781181A4 (enExample) |
| JP (2) | JP7562416B2 (enExample) |
| KR (1) | KR20200140836A (enExample) |
| CN (1) | CN112272698A (enExample) |
| AR (1) | AR115304A1 (enExample) |
| AU (1) | AU2019242887A1 (enExample) |
| BR (1) | BR112020019773A2 (enExample) |
| CA (1) | CA3112650A1 (enExample) |
| IL (2) | IL311366B2 (enExample) |
| MX (1) | MX2020010223A (enExample) |
| PH (1) | PH12020551584A1 (enExample) |
| SG (1) | SG11202009428YA (enExample) |
| TW (1) | TW202002997A (enExample) |
| WO (1) | WO2019191402A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10202104575WA (en) | 2016-11-04 | 2021-06-29 | Childrens Hospital Med Ct | Liver organoid compositions and methods of making and using same |
| CA3106634A1 (en) | 2018-07-26 | 2020-01-30 | Children's Hospital Medical Center | Hepato-biliary-pancreatic tissues and methods of making same |
| CN112823012A (zh) | 2018-09-12 | 2021-05-18 | 儿童医院医学中心 | 用于产生造血干细胞及其衍生物的类器官组合物 |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| CA3141807A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| US12534709B2 (en) | 2019-05-31 | 2026-01-27 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| KR102322635B1 (ko) * | 2021-06-11 | 2021-11-05 | 인제대학교 산학협력단 | 말초신경양 미세조직 제조방법 및 이의 용도 |
| AU2022304681A1 (en) * | 2021-07-02 | 2024-01-25 | Children’S Hospital Medical Center | Structurally complete organoids |
| WO2023171702A1 (ja) * | 2022-03-08 | 2023-09-14 | 慶應義塾 | オルガノイドの製造方法 |
| KR20250118284A (ko) * | 2024-01-29 | 2025-08-06 | (의) 삼성의료재단 | 중간엽 줄기세포 유래 췌도 오가노이드의 제조방법 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057430A2 (en) * | 2001-01-20 | 2002-07-25 | Cardion Ag | Pluripotent adult stem cells derived from regenerative tissue |
| US20050256077A1 (en) | 2004-03-30 | 2005-11-17 | Henning Susan J | Gastrointestinal stem cells and uses thereof |
| US20070026520A1 (en) * | 2005-07-29 | 2007-02-01 | Kelly James H | Novel cells, compositions, and methods |
| US20070128584A1 (en) | 2005-12-01 | 2007-06-07 | Illani Atwater | Method for isolation of cells |
| CN101668848B (zh) * | 2007-04-26 | 2014-10-22 | 雷蒙特亚特特拉维夫大学有限公司 | 来自口腔粘膜的多能自体干细胞和使用方法 |
| US20090269769A1 (en) | 2008-04-23 | 2009-10-29 | Asit Panja | Drug Discovery Methods Involving A Preclinical, In Vitro Isolated Gastrointestinal Epithelial Stem Cell-Like Progenitor Cell System |
| EP2326336B1 (en) * | 2008-07-30 | 2015-05-13 | Mesynthes Limited | Tissue scaffolds derived from forestomach extracellular matrix |
| US8895300B2 (en) * | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
| US8367316B2 (en) * | 2009-05-01 | 2013-02-05 | Alfagene Bioscience, Inc. | Human gastrointestinal stem cell-derived primary intestinal epithelial cell system and methods of use thereof |
| ES2819028T3 (es) * | 2009-10-30 | 2021-04-14 | Univ North Carolina Chapel Hill | Células madre multipotentes del árbol biliar extrahepático y métodos para su aislamiento |
| WO2012070014A2 (en) * | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| US9533013B2 (en) * | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| CN105087479A (zh) * | 2015-08-21 | 2015-11-25 | 深圳爱生再生医学科技有限公司 | 干细胞无血清培养基及干细胞的培养方法 |
-
2019
- 2019-03-28 CA CA3112650A patent/CA3112650A1/en active Pending
- 2019-03-28 JP JP2020552401A patent/JP7562416B2/ja active Active
- 2019-03-28 TW TW108111024A patent/TW202002997A/zh unknown
- 2019-03-28 AR ARP190100808A patent/AR115304A1/es unknown
- 2019-03-28 US US16/368,524 patent/US20190300849A1/en active Pending
- 2019-03-28 MX MX2020010223A patent/MX2020010223A/es unknown
- 2019-03-28 IL IL311366A patent/IL311366B2/en unknown
- 2019-03-28 BR BR112020019773-4A patent/BR112020019773A2/pt not_active IP Right Cessation
- 2019-03-28 KR KR1020207030724A patent/KR20200140836A/ko not_active Ceased
- 2019-03-28 CN CN201980033560.8A patent/CN112272698A/zh active Pending
- 2019-03-28 IL IL277552A patent/IL277552B2/en unknown
- 2019-03-28 SG SG11202009428YA patent/SG11202009428YA/en unknown
- 2019-03-28 EP EP19774805.6A patent/EP3781181A4/en not_active Withdrawn
- 2019-03-28 WO PCT/US2019/024543 patent/WO2019191402A1/en not_active Ceased
- 2019-03-28 AU AU2019242887A patent/AU2019242887A1/en not_active Abandoned
-
2020
- 2020-09-28 PH PH12020551584A patent/PH12020551584A1/en unknown
-
2024
- 2024-03-21 JP JP2024044463A patent/JP2024075687A/ja active Pending
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