JP2024054242A5 - - Google Patents
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- JP2024054242A5 JP2024054242A5 JP2024017072A JP2024017072A JP2024054242A5 JP 2024054242 A5 JP2024054242 A5 JP 2024054242A5 JP 2024017072 A JP2024017072 A JP 2024017072A JP 2024017072 A JP2024017072 A JP 2024017072A JP 2024054242 A5 JP2024054242 A5 JP 2024054242A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecules
- sample
- filler
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000039446 nucleic acids Human genes 0.000 claims 34
- 108020004707 nucleic acids Proteins 0.000 claims 34
- 150000007523 nucleic acids Chemical class 0.000 claims 34
- 238000000034 method Methods 0.000 claims 29
- 239000000945 filler Substances 0.000 claims 9
- 102000053602 DNA Human genes 0.000 claims 6
- 108020004414 DNA Proteins 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 239000011230 binding agent Substances 0.000 claims 4
- RYVNIFSIEDRLSJ-UHFFFAOYSA-N 5-(hydroxymethyl)cytosine Chemical compound NC=1NC(=O)N=CC=1CO RYVNIFSIEDRLSJ-UHFFFAOYSA-N 0.000 claims 2
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 108700043128 MBD2 Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 230000006607 hypermethylation Effects 0.000 claims 1
- 230000002621 immunoprecipitating effect Effects 0.000 claims 1
- 238000001114 immunoprecipitation Methods 0.000 claims 1
- 230000009871 nonspecific binding Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662331070P | 2016-05-03 | 2016-05-03 | |
| US62/331,070 | 2016-05-03 | ||
| JP2018557336A JP6979554B2 (ja) | 2016-05-03 | 2017-05-03 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
| JP2021103482A JP7434215B2 (ja) | 2016-05-03 | 2021-06-22 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021103482A Division JP7434215B2 (ja) | 2016-05-03 | 2021-06-22 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024054242A JP2024054242A (ja) | 2024-04-16 |
| JP2024054242A5 true JP2024054242A5 (https=) | 2024-07-23 |
Family
ID=60202577
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557336A Active JP6979554B2 (ja) | 2016-05-03 | 2017-05-03 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
| JP2021103482A Active JP7434215B2 (ja) | 2016-05-03 | 2021-06-22 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
| JP2024017072A Pending JP2024054242A (ja) | 2016-05-03 | 2024-02-07 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557336A Active JP6979554B2 (ja) | 2016-05-03 | 2017-05-03 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
| JP2021103482A Active JP7434215B2 (ja) | 2016-05-03 | 2021-06-22 | 無細胞メチル化ｄｎａを捕捉する方法及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US11078475B2 (https=) |
| EP (2) | EP4425178A3 (https=) |
| JP (3) | JP6979554B2 (https=) |
| KR (3) | KR102522067B1 (https=) |
| CN (1) | CN109415763A (https=) |
| BR (1) | BR112018072536A2 (https=) |
| WO (1) | WO2017190215A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| KR102522067B1 (ko) * | 2016-05-03 | 2023-04-13 | 유니버시티 헬스 네트워크 | 무-세포 메틸화된 dna의 포획 방법 및 이의 이용 |
| MX2019007444A (es) | 2016-12-22 | 2019-08-16 | Guardant Health Inc | Metodos y sistemas para analisis de moleculas de acido nucleico. |
| CA3063405A1 (en) * | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Universal early cancer diagnostics |
| US12227737B2 (en) * | 2017-07-12 | 2025-02-18 | University Health Network | Cancer detection and classification using methylome analysis |
| BR112020000681A2 (pt) * | 2017-07-12 | 2020-07-14 | University Health Network | detecção e classificação de cancro utilizando análise de metilome |
| US20210156863A1 (en) * | 2017-11-03 | 2021-05-27 | University Health Network | Cancer detection, classification, prognostication, therapy prediction and therapy monitoring using methylome analysis |
| CN108796057A (zh) * | 2018-06-29 | 2018-11-13 | 上海交通大学 | 一种少量样品全基因组dna甲基化的检测方法及试剂盒 |
| CN108796039B (zh) * | 2018-06-29 | 2021-10-08 | 上海交通大学 | 一种用于dna甲基化检测的试剂盒与方法及应用 |
| CN109023537B (zh) * | 2018-09-04 | 2021-10-08 | 上海交通大学 | 一种微量dna样品高通量测序文库的构建技术 |
| CN109097439A (zh) * | 2018-09-04 | 2018-12-28 | 上海交通大学 | 一种检测少量样品全基因组dna甲基化的方法 |
| WO2020160414A1 (en) * | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| CN109825559A (zh) * | 2019-03-11 | 2019-05-31 | 上海交通大学 | 一种血浆cfDNA全局性甲基化检测方法及应用 |
| US11891653B2 (en) | 2019-09-30 | 2024-02-06 | Guardant Health, Inc. | Compositions and methods for analyzing cell-free DNA in methylation partitioning assays |
| CN115087744A (zh) * | 2019-11-06 | 2022-09-20 | 大学健康网络 | 用于无细胞MeDIP测序的合成加标对照及其使用方法 |
| EP4617375A3 (en) * | 2019-11-26 | 2025-10-29 | Guardant Health, Inc. | Methods, compositions and systems for improving the binding of methylated polynucleotides |
| CN111154846A (zh) * | 2020-01-13 | 2020-05-15 | 四川大学华西医院 | 一种甲基化核酸的检测方法 |
| EP4715052A2 (en) * | 2020-05-18 | 2026-03-25 | Myriad Women's Health, Inc. | Nucleic acid sample enrichment and screening methods |
| US12592321B2 (en) | 2020-06-19 | 2026-03-31 | University Health Network | Cancer detection and classification using methylome analysis |
| KR102332540B1 (ko) | 2020-07-02 | 2021-11-29 | 의료법인 성광의료재단 | 다운증후군 특이적인 후성학적 마커를 이용한 다운증후군 진단 방법 |
| KR102332539B1 (ko) | 2020-07-02 | 2021-11-29 | 의료법인 성광의료재단 | 다운증후군 진단용 후성학적 바이오마커 조성물 및 이의 용도 |
| EP4585697A3 (en) * | 2020-07-30 | 2025-08-06 | Guardant Health, Inc. | Methods for isolating cell-free dna |
| AU2021345359A1 (en) | 2020-09-21 | 2023-05-11 | Enumera Molecular, Inc. | Compositions and methods for isolation of cell-free dna |
| EP4222278A1 (en) * | 2020-09-30 | 2023-08-09 | Guardant Health, Inc. | Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease |
| JP2023547620A (ja) | 2020-10-23 | 2023-11-13 | ガーダント ヘルス， インコーポレイテッド | 分配および塩基変換を使用してｄｎａを解析するための組成物および方法 |
| JP2024525190A (ja) * | 2021-06-18 | 2024-07-10 | シングレラ ジェノミクス （チャンスー） リミテッド | 腫瘍評価のための物質及び方法 |
| JP2024523401A (ja) * | 2021-06-21 | 2024-06-28 | ガーダント ヘルス， インコーポレイテッド | コピー数情報に基づく組織起源分析のための方法および組成物 |
| CN113621691A (zh) * | 2021-09-27 | 2021-11-09 | 广东省妇幼保健院 | 基于一代测序技术直接检测KLF1基因启动子区CpG甲基化的方法和试剂盒 |
| CN114045342A (zh) * | 2021-12-01 | 2022-02-15 | 大连晶泰生物技术有限公司 | 一种游离DNA(cfDNA)甲基化突变的检测方法及试剂盒 |
| WO2023107709A1 (en) * | 2021-12-10 | 2023-06-15 | Adela, Inc. | Methods and systems for generating sequencing libraries |
| WO2023192635A2 (en) * | 2022-04-01 | 2023-10-05 | Twist Bioscience Corporation | Libraries for methylation analysis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818762B2 (en) * | 2001-05-25 | 2004-11-16 | Maine Molecular Quality Controls, Inc. | Compositions and methods relating to nucleic acid reference standards |
| AU2002363062B2 (en) * | 2001-10-09 | 2007-03-22 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| CN101802223A (zh) * | 2007-08-15 | 2010-08-11 | 香港大学 | 用于高通量亚硫酸氢盐dna-测序的方法和组合物及其用途 |
| CN103443338B (zh) * | 2011-02-02 | 2017-09-22 | 华盛顿大学商业化中心 | 大规模平行邻接作图 |
| US8895249B2 (en) * | 2012-06-15 | 2014-11-25 | Illumina, Inc. | Kinetic exclusion amplification of nucleic acid libraries |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| SI4056712T1 (sl) * | 2012-09-20 | 2024-10-30 | The Chinese University Of Hong Kong | Neinvazivno določanje metiloma tumorja iz plazme |
| US10706957B2 (en) * | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| JP6681841B2 (ja) | 2014-05-09 | 2020-04-15 | ライフコーデックス アーゲー | 特別な細胞タイプに由来するｄｎａの検出とそれに関連する方法 |
| TWI813141B (zh) * | 2014-07-18 | 2023-08-21 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| KR102522067B1 (ko) * | 2016-05-03 | 2023-04-13 | 유니버시티 헬스 네트워크 | 무-세포 메틸화된 dna의 포획 방법 및 이의 이용 |
| BR112020000681A2 (pt) * | 2017-07-12 | 2020-07-14 | University Health Network | detecção e classificação de cancro utilizando análise de metilome |
| US20210156863A1 (en) * | 2017-11-03 | 2021-05-27 | University Health Network | Cancer detection, classification, prognostication, therapy prediction and therapy monitoring using methylome analysis |
-
2017
- 2017-05-03 KR KR1020217023549A patent/KR102522067B1/ko active Active
- 2017-05-03 EP EP24176389.5A patent/EP4425178A3/en active Pending
- 2017-05-03 CN CN201780032740.5A patent/CN109415763A/zh active Pending
- 2017-05-03 WO PCT/CA2017/000108 patent/WO2017190215A1/en not_active Ceased
- 2017-05-03 KR KR1020237012338A patent/KR20230054746A/ko not_active Ceased
- 2017-05-03 US US16/098,620 patent/US11078475B2/en active Active
- 2017-05-03 KR KR1020187034995A patent/KR102359767B1/ko active Active
- 2017-05-03 BR BR112018072536-6A patent/BR112018072536A2/pt not_active Application Discontinuation
- 2017-05-03 JP JP2018557336A patent/JP6979554B2/ja active Active
- 2017-05-03 EP EP17792306.7A patent/EP3452615A4/en not_active Withdrawn
-
2021
- 2021-06-21 US US17/353,756 patent/US20220119796A1/en active Pending
- 2021-06-22 JP JP2021103482A patent/JP7434215B2/ja active Active
- 2021-11-04 US US17/519,350 patent/US11560558B2/en active Active
-
2022
- 2022-11-28 US US18/059,370 patent/US20230287384A1/en active Pending
-
2024
- 2024-02-07 JP JP2024017072A patent/JP2024054242A/ja active Pending
-
2025
- 2025-06-18 US US19/241,820 patent/US20250313825A1/en active Pending
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