JP2021509587A5 - - Google Patents
Info
- Publication number
- JP2021509587A5 JP2021509587A5 JP2020537593A JP2020537593A JP2021509587A5 JP 2021509587 A5 JP2021509587 A5 JP 2021509587A5 JP 2020537593 A JP2020537593 A JP 2020537593A JP 2020537593 A JP2020537593 A JP 2020537593A JP 2021509587 A5 JP2021509587 A5 JP 2021509587A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- target nucleic
- modified
- sequence
- dhu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022139122A JP7539948B2 (ja) | 2018-01-08 | 2022-09-01 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
| JP2024135325A JP2024161477A (ja) | 2018-01-08 | 2024-08-14 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862614798P | 2018-01-08 | 2018-01-08 | |
| US62/614,798 | 2018-01-08 | ||
| US201862660523P | 2018-04-20 | 2018-04-20 | |
| US62/660,523 | 2018-04-20 | ||
| US201862771409P | 2018-11-26 | 2018-11-26 | |
| US62/771,409 | 2018-11-26 | ||
| PCT/US2019/012627 WO2019136413A1 (en) | 2018-01-08 | 2019-01-08 | Bisulfite-free, base-resolution identification of cytosine modifications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022139122A Division JP7539948B2 (ja) | 2018-01-08 | 2022-09-01 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021509587A JP2021509587A (ja) | 2021-04-01 |
| JP2021509587A5 true JP2021509587A5 (https=) | 2022-04-08 |
| JP7136899B2 JP7136899B2 (ja) | 2022-09-13 |
Family
ID=67143801
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020537593A Active JP7136899B2 (ja) | 2018-01-08 | 2019-01-08 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
| JP2022139122A Active JP7539948B2 (ja) | 2018-01-08 | 2022-09-01 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
| JP2024135325A Pending JP2024161477A (ja) | 2018-01-08 | 2024-08-14 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022139122A Active JP7539948B2 (ja) | 2018-01-08 | 2022-09-01 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
| JP2024135325A Pending JP2024161477A (ja) | 2018-01-08 | 2024-08-14 | シトシン修飾の、亜硫酸水素塩非含有、塩基分解能特定 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US12071660B2 (https=) |
| EP (1) | EP3737748A4 (https=) |
| JP (3) | JP7136899B2 (https=) |
| KR (3) | KR20250026369A (https=) |
| CN (2) | CN111971386A (https=) |
| AU (3) | AU2019205416B2 (https=) |
| BR (1) | BR112020013718A2 (https=) |
| CA (1) | CA3087915C (https=) |
| IL (2) | IL296932B2 (https=) |
| MA (1) | MA51633A (https=) |
| MX (2) | MX395068B (https=) |
| NZ (1) | NZ765943A (https=) |
| SG (1) | SG11202006511YA (https=) |
| WO (1) | WO2019136413A1 (https=) |
| ZA (1) | ZA202004769B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| NZ765943A (en) * | 2018-01-08 | 2022-10-28 | Ludwig Inst For Cancer Res Ltd | Bisulfite-free, base-resolution identification of cytosine modifications |
| WO2019160994A1 (en) | 2018-02-14 | 2019-08-22 | Bluestar Genomics, Inc. | Methods for the epigenetic analysis of dna, particularly cell-free dna |
| WO2020160414A1 (en) | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| KR20220015367A (ko) | 2019-05-31 | 2022-02-08 | 프리놈 홀딩스, 인크. | 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템 |
| EP3997245B1 (en) * | 2019-07-08 | 2023-10-18 | Ludwig Institute for Cancer Research Ltd | Bisulfite-free, whole genome methylation analysis |
| AU2020345621A1 (en) * | 2019-09-09 | 2022-04-07 | University Of Utah Research Foundation | Targeted sequencing to detect and quantify low levels of methylated DNA |
| EP4041888A4 (en) | 2019-10-11 | 2023-11-01 | Guardant Health, Inc. | USE OF CELLULAR BACTERIAL NUCLEIC ACIDS FOR CANCER DETECTION |
| CN110669824A (zh) * | 2019-10-11 | 2020-01-10 | 广州迈森致远基因科技有限公司 | 低起始量血浆游离dna甲基化建库试剂盒及方法 |
| CN115087744A (zh) * | 2019-11-06 | 2022-09-20 | 大学健康网络 | 用于无细胞MeDIP测序的合成加标对照及其使用方法 |
| CN110820050A (zh) * | 2019-11-22 | 2020-02-21 | 北京吉因加科技有限公司 | 全基因组甲基化非重亚硫酸氢盐测序文库及构建 |
| WO2021161192A1 (en) | 2020-02-11 | 2021-08-19 | The Chancellor, Masters And Scholars Of The University Of Oxford | Targeted, long-read nucleic acid sequencing for the determination of cytosine modifications |
| CN113373207A (zh) * | 2020-02-25 | 2021-09-10 | 深圳华大基因科技服务有限公司 | 确定胞嘧啶修饰的方法 |
| EP4585697A3 (en) | 2020-07-30 | 2025-08-06 | Guardant Health, Inc. | Methods for isolating cell-free dna |
| EP4083231A1 (en) | 2020-07-30 | 2022-11-02 | Cambridge Epigenetix Limited | Compositions and methods for nucleic acid analysis |
| AU2021329899A1 (en) | 2020-08-19 | 2023-03-09 | Exact Sciences Corporation | Detecting non-hodgkin lymphoma |
| US20230357833A1 (en) * | 2020-09-14 | 2023-11-09 | Ludwig Institute For Cancer Research Ltd | Cytosine modification analysis |
| JP2023547620A (ja) * | 2020-10-23 | 2023-11-13 | ガーダント ヘルス， インコーポレイテッド | 分配および塩基変換を使用してｄｎａを解析するための組成物および方法 |
| GB202017653D0 (en) | 2020-11-09 | 2020-12-23 | Cambridge Entpr Ltd | Methods for detection of nucleotide modification |
| KR20230150814A (ko) | 2021-01-29 | 2023-10-31 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 다양한 유형의 암에 대한 존재 또는 부재의 검출 |
| JP7646850B2 (ja) * | 2021-02-09 | 2025-03-17 | エフ． ホフマン－ラ ロシュ アーゲー | 核酸中のメチル化の塩基レベル検出のための方法 |
| KR20230156711A (ko) * | 2021-03-15 | 2023-11-14 | 일루미나, 인코포레이티드 | S-아데노실-L-메티오닌 유사체(xSAM)를 사용한 메틸시토신 및 이의 유도체의 검출 |
| GB202109469D0 (en) | 2021-06-30 | 2021-08-11 | Cambridge Entpr Ltd | Methods for detecting modified nucleotides |
| CA3226747A1 (en) * | 2021-07-27 | 2023-02-02 | Chunxiao Song | Compositions and methods related to tet-assisted pyridine borane sequencing for cell-free dna |
| CN113846160B (zh) * | 2021-09-14 | 2024-08-20 | 翌圣生物科技(上海)股份有限公司 | 正向筛选的胞嘧啶甲基化快速检测方法及过氧钨酸盐在将5hmC氧化为thT中的应用 |
| CN114085894A (zh) * | 2021-11-03 | 2022-02-25 | 翌圣生物科技(上海)股份有限公司 | 核酸甲基化胞嘧啶转化方法 |
| CN118202065A (zh) * | 2021-11-15 | 2024-06-14 | 深圳华大智造科技股份有限公司 | 一种检测全基因组范围内的dna甲基化修饰的方法 |
| EP4457357A4 (en) * | 2021-12-29 | 2026-01-07 | Found Medicine Inc | DETECTION OF GENETIC AND EPIGENETIC INFORMATION IN A SINGLE WORKFLOW |
| CN114045345B (zh) * | 2022-01-07 | 2022-04-29 | 臻和(北京)生物科技有限公司 | 基于游离dna的基因组癌变信息检测系统和检测方法 |
| AU2023234670A1 (en) * | 2022-03-15 | 2024-01-18 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection |
| WO2023183841A2 (en) * | 2022-03-23 | 2023-09-28 | Exact Sciences Corporation | Compositions and methods for tet-assisted oxidation of methylated nucleotide bases |
| EP4499859A1 (en) | 2022-03-31 | 2025-02-05 | Illumina, Inc. | Compositions including aqueous amine borane complexes and polynucleotides, and methods of using the same to detect methylcytosine or hydroxymethylcytosine |
| WO2024042217A1 (en) | 2022-08-25 | 2024-02-29 | Illumina, Inc. | Methods of modifying methylcytosine or derivative thereof using a nucleophilic molecule, and methods of using the same to detect the methylcytosine or derivative thereof in a polynucleotide |
| WO2024073043A1 (en) | 2022-09-30 | 2024-04-04 | Illumina, Inc. | Methods of using cpg binding proteins in mapping modified cytosine nucleotides |
| EP4658807A1 (en) | 2023-02-01 | 2025-12-10 | Illumina, Inc. | Methods of modifying methylcytosine or derivative thereof using a photoredox reaction, and methods of using the same to detect the methylcytosine or derivative thereof in a polynucleotide |
| WO2024164173A1 (en) * | 2023-02-08 | 2024-08-15 | Peking University | 5-hydroxymethylcytosine sequencing |
| CN116287166A (zh) * | 2023-04-19 | 2023-06-23 | 纳昂达(南京)生物科技有限公司 | 甲基化测序接头及其应用 |
| KR20260005347A (ko) | 2023-04-28 | 2026-01-09 | 이그잭트 사이언시스 이노베이션 리미티드 | 조작된 tet 효소 및 후성유전학 및 차세대 서열분석(ngs), 예컨대 tet-보조 피리딘 보란 서열분석(taps)에서의 용도 |
| WO2024249061A1 (en) * | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Detecting a methylated nucleotide using a quencher |
| WO2025054389A1 (en) * | 2023-09-07 | 2025-03-13 | Illumina, Inc. | Identification of methylated cytosine using landmarks |
| WO2025085492A1 (en) * | 2023-10-17 | 2025-04-24 | Exact Sciences Corporation | Borane reducing reagents |
| WO2026055641A1 (en) | 2024-09-06 | 2026-03-12 | Exact Sciences Corporation | Methods and compositions for preparing biomolecule analytes from complex samples |
| WO2026072259A1 (en) | 2024-09-30 | 2026-04-02 | Illumina, Inc. | Methods, systems, and kits for sequencing nucleic acids with deamination and mutagenesis |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| WO2011127136A1 (en) | 2010-04-06 | 2011-10-13 | University Of Chicago | Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc) |
| EP2694686B2 (en) | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| RU2612902C2 (ru) | 2011-07-29 | 2017-03-13 | Кембридж Эпидженетикс Лимитед | Способы обнаружения модификации нуклеотидов |
| JP6224689B2 (ja) | 2012-03-15 | 2017-11-01 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | シトシンとこれの修飾物とを識別するための、およびメチローム分析のための方法および組成物 |
| US9267117B2 (en) * | 2012-03-15 | 2016-02-23 | New England Biolabs, Inc. | Mapping cytosine modifications |
| WO2014165770A1 (en) * | 2013-04-05 | 2014-10-09 | The University Of Chicago | Single-base resolution sequencing of 5-formylcytosine (5fc) and 5-carboxylcytosine (5cac) |
| US20160194696A1 (en) | 2013-08-09 | 2016-07-07 | New England Biolabs, Inc. | Detecting, Sequencing and/or Mapping 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution |
| WO2017039002A1 (ja) | 2015-09-04 | 2017-03-09 | 国立大学法人東京大学 | ５－ヒドロキシメチルシトシン酸化剤及び５－ヒドロキシメチルシトシン解析方法 |
| US11162139B2 (en) | 2016-03-02 | 2021-11-02 | Shanghai Epican Genetech Co. Ltd. | Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine |
| WO2017176630A1 (en) | 2016-04-07 | 2017-10-12 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
| NZ765943A (en) | 2018-01-08 | 2022-10-28 | Ludwig Inst For Cancer Res Ltd | Bisulfite-free, base-resolution identification of cytosine modifications |
| WO2019160994A1 (en) | 2018-02-14 | 2019-08-22 | Bluestar Genomics, Inc. | Methods for the epigenetic analysis of dna, particularly cell-free dna |
-
2019
- 2019-01-08 NZ NZ765943A patent/NZ765943A/en unknown
- 2019-01-08 MA MA051633A patent/MA51633A/fr unknown
- 2019-01-08 SG SG11202006511YA patent/SG11202006511YA/en unknown
- 2019-01-08 KR KR1020257004045A patent/KR20250026369A/ko active Pending
- 2019-01-08 IL IL296932A patent/IL296932B2/en unknown
- 2019-01-08 AU AU2019205416A patent/AU2019205416B2/en active Active
- 2019-01-08 KR KR1020237005878A patent/KR102768046B1/ko active Active
- 2019-01-08 IL IL275850A patent/IL275850B2/en unknown
- 2019-01-08 JP JP2020537593A patent/JP7136899B2/ja active Active
- 2019-01-08 KR KR1020207022948A patent/KR102503884B1/ko active Active
- 2019-01-08 CN CN201980011272.2A patent/CN111971386A/zh active Pending
- 2019-01-08 EP EP19736010.0A patent/EP3737748A4/en active Pending
- 2019-01-08 CA CA3087915A patent/CA3087915C/en active Active
- 2019-01-08 BR BR112020013718-9A patent/BR112020013718A2/pt unknown
- 2019-01-08 US US16/960,510 patent/US12071660B2/en active Active
- 2019-01-08 WO PCT/US2019/012627 patent/WO2019136413A1/en not_active Ceased
- 2019-01-08 CN CN202210527768.9A patent/CN115181783A/zh active Pending
- 2019-01-08 MX MX2020007259A patent/MX395068B/es unknown
-
2020
- 2020-07-13 MX MX2022010611A patent/MX2022010611A/es unknown
- 2020-07-31 ZA ZA2020/04769A patent/ZA202004769B/en unknown
-
2021
- 2021-03-15 US US17/201,825 patent/US11306355B2/en active Active
-
2022
- 2022-03-07 US US17/688,427 patent/US11987843B2/en active Active
- 2022-03-07 US US17/688,424 patent/US11959136B2/en active Active
- 2022-09-01 JP JP2022139122A patent/JP7539948B2/ja active Active
- 2022-09-22 AU AU2022235598A patent/AU2022235598B2/en active Active
-
2024
- 2024-07-23 US US18/781,157 patent/US20250011861A1/en active Pending
- 2024-08-14 JP JP2024135325A patent/JP2024161477A/ja active Pending
-
2025
- 2025-03-11 AU AU2025201761A patent/AU2025201761A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021509587A5 (https=) | ||
| WO2019136413A4 (en) | Bisulfite-free, base-resolution identification of cytosine modifications | |
| JP2024103502A (ja) | ニューラルネットワークを使用して倍数性状態を呼び出すための方法およびシステム | |
| AU2012304328B2 (en) | Methods for obtaining a sequence | |
| US20210257048A1 (en) | Methods and systems for calling mutations | |
| RU2565550C2 (ru) | Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров | |
| US11608518B2 (en) | Methods for analyzing nucleic acids | |
| CN111032881A (zh) | 核酸的精确和大规模平行定量 | |
| US20180237950A1 (en) | Methods and compositions for in silico long read sequencing | |
| JP2021512648A (ja) | 核酸プライマー伸長のための組成物および技術 | |
| KR102932555B1 (ko) | 희석 또는 비-정제된 샘플에서 핵산의 정확한 병렬 정량분석 방법 | |
| CN104271770A (zh) | 靶dna富集和测序 | |
| JP2023553984A (ja) | 二重鎖修復の方法 | |
| JP2025533890A (ja) | Ｔｅｔ支援ピリジンボランシーケンシング | |
| US20250361549A1 (en) | Detection of epigenetic cytosine modification | |
| WO2026050179A1 (en) | Tumor fraction (tf) is associated with real-world progression-free survival (rwpfs) in non-small-cell lung cancer (nsclc) patients treated with platinum-based chemotherapy (chemo) | |
| WO2026050287A1 (en) | Methylation biomarkers for osimertinib treatment management | |
| JP2025517399A (ja) | 腫瘍アッセイのための組成物及び方法 | |
| JPH0528118B2 (https=) | ||
| Tserovski | Chemical Labeling and Next-generation Sequencing for Detection of RNA-modifications |