CN109415763A - 捕获无细胞的甲基化dna的方法及其用途 - Google Patents

捕获无细胞的甲基化dna的方法及其用途 Download PDF

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Publication number
CN109415763A
CN109415763A CN201780032740.5A CN201780032740A CN109415763A CN 109415763 A CN109415763 A CN 109415763A CN 201780032740 A CN201780032740 A CN 201780032740A CN 109415763 A CN109415763 A CN 109415763A
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dna
sample
cell
free
methylation
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丹尼尔·迪尼兹·德·卡尔瓦霍
沈淑怡
拉贾特·辛加尼亚
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University Health Network
Mt Sinai Hospital
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CN201780032740.5A 2016-05-03 2017-05-03 捕获无细胞的甲基化dna的方法及其用途 Pending CN109415763A (zh)

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US201662331070P 2016-05-03 2016-05-03
US62/331,070 2016-05-03
PCT/CA2017/000108 WO2017190215A1 (en) 2016-05-03 2017-05-03 Methods of capturing cell-free methylated dna and uses of same

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US (5) US11078475B2 (https=)
EP (2) EP4425178A3 (https=)
JP (3) JP6979554B2 (https=)
KR (3) KR102522067B1 (https=)
CN (1) CN109415763A (https=)
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CN108796039A (zh) * 2018-06-29 2018-11-13 上海交通大学 一种用于dna甲基化检测的试剂盒与方法及应用
CN109825559A (zh) * 2019-03-11 2019-05-31 上海交通大学 一种血浆cfDNA全局性甲基化检测方法及应用
CN113621691A (zh) * 2021-09-27 2021-11-09 广东省妇幼保健院 基于一代测序技术直接检测KLF1基因启动子区CpG甲基化的方法和试剂盒
CN114045342A (zh) * 2021-12-01 2022-02-15 大连晶泰生物技术有限公司 一种游离DNA(cfDNA)甲基化突变的检测方法及试剂盒
CN114746560A (zh) * 2019-11-26 2022-07-12 夸登特健康公司 改进甲基化多核苷酸结合的方法、组合物和系统
CN115087744A (zh) * 2019-11-06 2022-09-20 大学健康网络 用于无细胞MeDIP测序的合成加标对照及其使用方法
US12592321B2 (en) 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis

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CA3063405A1 (en) * 2017-05-12 2018-11-15 President And Fellows Of Harvard College Universal early cancer diagnostics
US12227737B2 (en) * 2017-07-12 2025-02-18 University Health Network Cancer detection and classification using methylome analysis
BR112020000681A2 (pt) * 2017-07-12 2020-07-14 University Health Network detecção e classificação de cancro utilizando análise de metilome
US20210156863A1 (en) * 2017-11-03 2021-05-27 University Health Network Cancer detection, classification, prognostication, therapy prediction and therapy monitoring using methylome analysis
CN108796057A (zh) * 2018-06-29 2018-11-13 上海交通大学 一种少量样品全基因组dna甲基化的检测方法及试剂盒
CN109023537B (zh) * 2018-09-04 2021-10-08 上海交通大学 一种微量dna样品高通量测序文库的构建技术
CN109097439A (zh) * 2018-09-04 2018-12-28 上海交通大学 一种检测少量样品全基因组dna甲基化的方法
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US11891653B2 (en) 2019-09-30 2024-02-06 Guardant Health, Inc. Compositions and methods for analyzing cell-free DNA in methylation partitioning assays
CN111154846A (zh) * 2020-01-13 2020-05-15 四川大学华西医院 一种甲基化核酸的检测方法
EP4715052A2 (en) * 2020-05-18 2026-03-25 Myriad Women's Health, Inc. Nucleic acid sample enrichment and screening methods
KR102332540B1 (ko) 2020-07-02 2021-11-29 의료법인 성광의료재단 다운증후군 특이적인 후성학적 마커를 이용한 다운증후군 진단 방법
KR102332539B1 (ko) 2020-07-02 2021-11-29 의료법인 성광의료재단 다운증후군 진단용 후성학적 바이오마커 조성물 및 이의 용도
EP4585697A3 (en) * 2020-07-30 2025-08-06 Guardant Health, Inc. Methods for isolating cell-free dna
AU2021345359A1 (en) 2020-09-21 2023-05-11 Enumera Molecular, Inc. Compositions and methods for isolation of cell-free dna
EP4222278A1 (en) * 2020-09-30 2023-08-09 Guardant Health, Inc. Compositions and methods for analyzing dna using partitioning and a methylation-dependent nuclease
JP2023547620A (ja) 2020-10-23 2023-11-13 ガーダント ヘルス， インコーポレイテッド 分配および塩基変換を使用してｄｎａを解析するための組成物および方法
JP2024525190A (ja) * 2021-06-18 2024-07-10 シングレラ ジェノミクス （チャンスー） リミテッド 腫瘍評価のための物質及び方法
JP2024523401A (ja) * 2021-06-21 2024-06-28 ガーダント ヘルス， インコーポレイテッド コピー数情報に基づく組織起源分析のための方法および組成物
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WO2023192635A2 (en) * 2022-04-01 2023-10-05 Twist Bioscience Corporation Libraries for methylation analysis

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108796039A (zh) * 2018-06-29 2018-11-13 上海交通大学 一种用于dna甲基化检测的试剂盒与方法及应用
CN108796039B (zh) * 2018-06-29 2021-10-08 上海交通大学 一种用于dna甲基化检测的试剂盒与方法及应用
CN109825559A (zh) * 2019-03-11 2019-05-31 上海交通大学 一种血浆cfDNA全局性甲基化检测方法及应用
CN115087744A (zh) * 2019-11-06 2022-09-20 大学健康网络 用于无细胞MeDIP测序的合成加标对照及其使用方法
CN114746560A (zh) * 2019-11-26 2022-07-12 夸登特健康公司 改进甲基化多核苷酸结合的方法、组合物和系统
US12592321B2 (en) 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
CN113621691A (zh) * 2021-09-27 2021-11-09 广东省妇幼保健院 基于一代测序技术直接检测KLF1基因启动子区CpG甲基化的方法和试剂盒
CN114045342A (zh) * 2021-12-01 2022-02-15 大连晶泰生物技术有限公司 一种游离DNA(cfDNA)甲基化突变的检测方法及试剂盒

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US11078475B2 (en) 2021-08-03
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JP6979554B2 (ja) 2021-12-15
EP4425178A3 (en) 2024-12-18

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