|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
JP2898040B2
(ja)
|
1990-01-26 |
1999-05-31 |
忠三 岸本 |
ｇｐ１３０蛋白質に対する抗体
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
DK0690873T3
(da)
|
1993-03-19 |
2003-09-29 |
Univ Johns Hopkins Med |
Vækstdifferentieringsfaktor-8
|
|
US6309853B1
(en)
|
1994-08-17 |
2001-10-30 |
The Rockfeller University |
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
|
|
US5856098A
(en)
|
1994-09-14 |
1999-01-05 |
Progenitor, Inc. |
Detection of a leptin receptor variant
|
|
US5912123A
(en)
|
1994-09-14 |
1999-06-15 |
Progenitor, Inc. |
Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology
|
|
US5643748A
(en)
|
1994-09-14 |
1997-07-01 |
Progenitor, Inc. |
HU-B1.219, a novel human hematopoietin receptor
|
|
US6451523B1
(en)
|
1994-09-14 |
2002-09-17 |
Interneuron Pharmaceuticals, Inc. |
Detection of a leptin receptor variant and methods for regulating obesity
|
|
FR2733250B1
(fr)
|
1995-04-21 |
1997-07-04 |
Diaclone |
Anticorps monoclonaux anti-gp130, et leurs utilisations
|
|
US6977240B1
(en)
|
1995-11-27 |
2005-12-20 |
Millenium Pharmaceuticals, Inc. |
Methods of using the OB receptor antibodies to treat bodyweight disorders
|
|
US6482927B1
(en)
|
1995-11-27 |
2002-11-19 |
Millennium Pharmaceuticals, Inc. |
Chimeric proteins comprising the extracellular domain of murine Ob receptor
|
|
AU721129B2
(en)
|
1996-01-08 |
2000-06-22 |
Genentech Inc. |
WSX receptor and ligands
|
|
US20050019325A1
(en)
|
1996-01-08 |
2005-01-27 |
Carter Paul J. |
WSX receptor agonist antibodies
|
|
AU2476301A
(en)
|
1996-01-16 |
2001-05-24 |
Rockefeller University, The |
DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
|
|
US7063958B1
(en)
|
1996-01-16 |
2006-06-20 |
The Rockefeller University |
Nucleic acids db, the receptor for leptin
|
|
AU1833197A
(en)
|
1996-01-18 |
1997-08-11 |
Progenitor, Inc. |
Detection of a leptin receptor variant and methods for regulating obesity
|
|
WO1997027286A1
(en)
|
1996-01-23 |
1997-07-31 |
Progenitor, Inc. |
Methods for using the obese gene and its gene product to stimulate hematopoietic development
|
|
US7067472B1
(en)
|
1996-06-04 |
2006-06-27 |
The Scripps Research Institute |
Diagnostic and therapeutic methods related to regulating energy mobilization with OB protein and OB antibodies
|
|
IT1288388B1
(it)
|
1996-11-19 |
1998-09-22 |
Angeletti P Ist Richerche Bio |
Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
|
|
US5965521A
(en)
|
1997-02-25 |
1999-10-12 |
Eli Lilly Company |
Pulsatile delivery of leptin receptor ligands
|
|
IL120733A0
(en)
|
1997-04-29 |
1997-08-14 |
Yeda Res & Dev |
Leptin as an inhibitor of cell proliferation
|
|
US6696411B1
(en)
|
1998-04-22 |
2004-02-24 |
Cornell Research Foundation, Inc. |
Canine erythropoietin gene and recombinant protein
|
|
GB9818110D0
(en)
|
1998-08-19 |
1998-10-14 |
Weston Medical Ltd |
Needleless injectors and other devices
|
|
US6096002A
(en)
|
1998-11-18 |
2000-08-01 |
Bioject, Inc. |
NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
|
|
HK1044159A1
(zh)
|
1998-12-01 |
2002-10-11 |
蛋白质设计实验室股份有限公司 |
抗γ-干扰素的人化抗体
|
|
AU767068B2
(en)
|
1999-06-11 |
2003-10-30 |
Baylor College Of Medicine |
Methods and compositions for control of bone formation via modulation of leptin activity
|
|
US6586251B2
(en)
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US20040253242A1
(en)
|
2000-12-05 |
2004-12-16 |
Bowdish Katherine S. |
Rationally designed antibodies
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
AU2002359288B2
(en)
|
2001-10-22 |
2008-07-31 |
Amgen, Inc. |
Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
|
|
KR100459493B1
(ko)
*
|
2002-01-31 |
2004-12-03 |
김기수 |
골다공증의 발생 위험을 예측하는 방법 및 이를 이용한골다공증의 유전적 위험 인자에 대한 진단 키트
|
|
AR047392A1
(es)
|
2002-10-22 |
2006-01-18 |
Wyeth Corp |
Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
|
|
FR2852397B1
(fr)
|
2003-03-10 |
2005-04-29 |
|
Utilisation des genes leprotl 1 et ob-rgrp pour le criblage de composes actifs sur la prise ou la perte de poids ou le diabete d'un sujet humain ou animal.
|
|
DE10353593A1
(de)
|
2003-11-17 |
2005-06-23 |
Klinikum der Universität München Großhadern-Innenstadt |
Leptinantagonist und Verfahren zur quantitativen Messung von Leptin
|
|
US8017634B2
(en)
|
2003-12-29 |
2011-09-13 |
President And Fellows Of Harvard College |
Compositions for treating obesity and insulin resistance disorders
|
|
ATE557042T1
(de)
|
2004-03-23 |
2012-05-15 |
Lilly Co Eli |
Anti-myostatin-antikörper
|
|
US7863240B2
(en)
|
2004-10-08 |
2011-01-04 |
Enzo Therapeutics, Inc. |
Methods and uses of leptin in hepatocellular carcinoma
|
|
US8969291B2
(en)
|
2004-10-08 |
2015-03-03 |
Enzo Therapeutics, Inc. |
Methods for decreasing leptin levels or activity for treating inflammation
|
|
ES2463476T3
(es)
|
2004-10-19 |
2014-05-28 |
Regeneron Pharmaceuticals, Inc. |
Método para generar un ratón homocigótico para una modificación genética
|
|
EP1812038A1
(en)
|
2004-11-18 |
2007-08-01 |
VIB vzw |
Fibronectin iii domain as leptin receptor antagonists
|
|
US7307142B2
(en)
|
2004-11-26 |
2007-12-11 |
Yissum Research And Development Company Of The Hebrew University Of Jerusalem |
Leptin antagonists
|
|
EP1877075A4
(en)
|
2005-04-25 |
2008-07-30 |
Pfizer |
ANTIBODY TO MYOSTATIN
|
|
US8008443B2
(en)
|
2005-04-26 |
2011-08-30 |
Medimmune, Llc |
Modulation of antibody effector function by hinge domain engineering
|
|
PL2407486T3
(pl)
|
2005-08-19 |
2018-05-30 |
Wyeth Llc |
Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8
|
|
PE20071101A1
(es)
|
2005-08-31 |
2007-12-21 |
Amgen Inc |
Polipeptidos y anticuerpos
|
|
EP1951756B1
(en)
|
2005-10-06 |
2015-01-07 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
|
BRPI0716249A2
(pt)
|
2006-09-05 |
2013-09-03 |
Lilly Co Eli |
anticorpos antimiostatina
|
|
CL2007002567A1
(es)
|
2006-09-08 |
2008-02-01 |
Amgen Inc |
Proteinas aisladas de enlace a activina a humana.
|
|
US8652466B2
(en)
|
2006-12-08 |
2014-02-18 |
Macrogenics, Inc. |
Methods for the treatment of disease using immunoglobulins having Fc regions with altered affinities for FcγRactivating and FcγRinhibiting
|
|
GB0715216D0
(en)
|
2007-08-03 |
2007-09-12 |
Asterion Ltd |
Leptin
|
|
WO2009045900A2
(en)
|
2007-09-28 |
2009-04-09 |
The Trustees Of Columbia University In The City Of New York |
Methods for treating or preventing diseases associated with low bone mass
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
CA2742969A1
(en)
|
2008-11-07 |
2010-05-14 |
Fabrus Llc |
Anti-dll4 antibodies and uses thereof
|
|
UY32341A
(es)
|
2008-12-19 |
2010-07-30 |
Glaxo Group Ltd |
Proteínas de unión antígeno novedosas
|
|
DK3622815T3
(da)
|
2009-07-08 |
2023-06-26 |
Kymab Ltd |
Gnavermodeller og terapeutiske molekyler
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
SMT202600080T1
(it)
|
2010-02-08 |
2026-03-09 |
Regeneron Pharma |
Topo con catena leggera comune
|
|
CN102947335B
(zh)
|
2010-04-15 |
2018-11-06 |
基因泰克公司 |
抗多聚遍在蛋白抗体及使用方法
|
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
|
TWI452136B
(zh)
*
|
2010-11-17 |
2014-09-11 |
中外製藥股份有限公司 |
A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation
|
|
KR20130118941A
(ko)
|
2011-02-10 |
2013-10-30 |
로슈 글리카트 아게 |
면역치료법
|
|
ME02106B
(me)
|
2011-02-25 |
2015-10-20 |
Regeneron Pharma |
Miševi sa adam6
|
|
US8790651B2
(en)
*
|
2011-07-21 |
2014-07-29 |
Zoetis Llc |
Interleukin-31 monoclonal antibody
|
|
HUE047278T2
(hu)
|
2011-08-05 |
2020-04-28 |
Regeneron Pharma |
Humanizált univerzális könnyûláncú egerek
|
|
DK2780368T3
(en)
|
2011-11-14 |
2018-02-05 |
Regeneron Pharma |
COMPOSITIONS AND PROCEDURES FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFIC ANTAGONIZATION OF GDF8 AND / OR ACTIVIN A
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
US20140013456A1
(en)
|
2012-03-16 |
2014-01-09 |
Regeneron Pharmaceuticals, Inc. |
Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
|
|
MX2014014891A
(es)
|
2012-06-05 |
2015-06-17 |
Regeneron Pharma |
Metodos para hacer anticuerpos biespecificos completamente humanos usando una cadena ligera comun.
|
|
PL3366705T3
(pl)
|
2012-09-12 |
2023-09-18 |
Genzyme Corporation |
FC zawierające polipeptydy o zmienionej glikozylacji i zmniejszonej funkcji efektorowej
|
|
TWI635098B
(zh)
|
2013-02-01 |
2018-09-11 |
再生元醫藥公司 |
含嵌合恆定區之抗體
|
|
TW201920262A
(zh)
|
2013-07-30 |
2019-06-01 |
美商再生元醫藥公司 |
抗活化素ａ之抗體及其用途
|
|
US20170051062A1
(en)
|
2014-02-18 |
2017-02-23 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and Pharmaceutical Compositions for the Treatment of Diseases Mediated by the NRP-1/OBR Complex Signaling Pathway
|
|
US20160075772A1
(en)
|
2014-09-12 |
2016-03-17 |
Regeneron Pharmaceuticals, Inc. |
Treatment of Fibrodysplasia Ossificans Progressiva
|
|
KR20170135967A
(ko)
|
2015-04-15 |
2017-12-08 |
리제너론 파마슈티칼스 인코포레이티드 |
Gdf8 억제제를 사용하여 강도 및 기능을 증가시키는 방법
|
|
TW202417497A
(zh)
|
2015-10-12 |
2024-05-01 |
美商再生元醫藥公司 |
活化瘦素受體的抗原結合蛋白
|
|
LT3538554T
(lt)
|
2016-11-08 |
2025-10-10 |
|
Antigeną surišantys baltymai, antagonizuojantys leptino receptorius
|
|
CN107760761A
(zh)
*
|
2017-11-10 |
2018-03-06 |
江苏省农业科学院 |
一种加强瘦素激发lepr信号转导的方法
|
|
SG11202005146VA
(en)
|
2017-12-18 |
2020-06-29 |
Regeneron Pharma |
Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof
|
|
US10131622B1
(en)
|
2018-01-03 |
2018-11-20 |
Saudi Arabian Upstream Technology Company |
N-hydroxyalkylated polyamines, methods of making N-hydroxyalkylated polyamines, and fluids containing an N-hydroxyalkylated polyamine
|
|
MX2020008991A
(es)
|
2018-03-01 |
2020-12-10 |
Regeneron Pharma |
Metodos para alterar la composicion corporal.
|
|
PT3773713T
(pt)
|
2018-04-06 |
2025-07-29 |
Regeneron Pharma |
Anticorpo agonista do recetor de leptina para usar no aumento da massa óssea num sujeito que sofre de disfunção metabólica ou de hipoleptinemia
|
|
KR20210104744A
(ko)
|
2018-12-18 |
2021-08-25 |
리제너론 파마슈티칼스 인코포레이티드 |
렙틴 수용체, gdf8 및 액티빈 a에 대한 길항제를 사용하여 체중 및 제지방 근육량을 향상시키기 위한 조성물 및 방법
|
|
KR20230069969A
(ko)
|
2020-09-15 |
2023-05-19 |
리제너론 파마슈티칼스 인코포레이티드 |
통증에 대한 lepr 아고니스트의 사용
|