JP2024041955A5 - - Google Patents
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- Publication number
- JP2024041955A5 JP2024041955A5 JP2024005418A JP2024005418A JP2024041955A5 JP 2024041955 A5 JP2024041955 A5 JP 2024041955A5 JP 2024005418 A JP2024005418 A JP 2024005418A JP 2024005418 A JP2024005418 A JP 2024005418A JP 2024041955 A5 JP2024041955 A5 JP 2024041955A5
- Authority
- JP
- Japan
- Prior art keywords
- thymic tissue
- derived product
- thymic
- tissue
- viable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002992 thymic effect Effects 0.000 claims 73
- 210000001519 tissue Anatomy 0.000 claims 66
- 230000000735 allogeneic effect Effects 0.000 claims 36
- 210000000056 organ Anatomy 0.000 claims 20
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 230000003750 conditioning effect Effects 0.000 claims 13
- 239000007787 solid Substances 0.000 claims 13
- 239000012634 fragment Substances 0.000 claims 12
- 102000011782 Keratins Human genes 0.000 claims 11
- 108010076876 Keratins Proteins 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 210000001541 thymus gland Anatomy 0.000 claims 11
- 238000010186 staining Methods 0.000 claims 9
- 230000001506 immunosuppresive effect Effects 0.000 claims 8
- 229960003444 immunosuppressant agent Drugs 0.000 claims 7
- 239000003018 immunosuppressive agent Substances 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 238000012423 maintenance Methods 0.000 claims 6
- 239000003862 glucocorticoid Substances 0.000 claims 5
- 230000001861 immunosuppressant effect Effects 0.000 claims 4
- 229940122739 Calcineurin inhibitor Drugs 0.000 claims 3
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims 3
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims 3
- 108010044091 Globulins Proteins 0.000 claims 3
- 102000006395 Globulins Human genes 0.000 claims 3
- 230000001494 anti-thymocyte effect Effects 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 210000003386 epithelial cell of thymus gland Anatomy 0.000 claims 3
- 239000002348 inosinate dehydrogenase inhibitor Substances 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 3
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 210000002536 stromal cell Anatomy 0.000 claims 3
- 238000002054 transplantation Methods 0.000 claims 3
- 108700028369 Alleles Proteins 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 229940121740 Inosine monophosphate dehydrogenase inhibitor Drugs 0.000 claims 2
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 229960002170 azathioprine Drugs 0.000 claims 2
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 2
- 229960001967 tacrolimus Drugs 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- 206010062016 Immunosuppression Diseases 0.000 claims 1
- 229940046731 calcineurin inhibitors Drugs 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- 229960000334 methylprednisolone sodium succinate Drugs 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 210000003314 quadriceps muscle Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862634377P | 2018-02-23 | 2018-02-23 | |
| US62/634,377 | 2018-02-23 | ||
| PCT/US2019/019137 WO2019165197A1 (en) | 2018-02-23 | 2019-02-22 | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| JP2020543913A JP7499178B2 (ja) | 2018-02-23 | 2019-02-22 | 同種固形臓器移植に対するドナー特異的寛容を促進する培養胸腺組織移植 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543913A Division JP7499178B2 (ja) | 2018-02-23 | 2019-02-22 | 同種固形臓器移植に対するドナー特異的寛容を促進する培養胸腺組織移植 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024041955A JP2024041955A (ja) | 2024-03-27 |
| JP2024041955A5 true JP2024041955A5 (https=) | 2024-09-03 |
Family
ID=67687403
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543913A Active JP7499178B2 (ja) | 2018-02-23 | 2019-02-22 | 同種固形臓器移植に対するドナー特異的寛容を促進する培養胸腺組織移植 |
| JP2024005418A Pending JP2024041955A (ja) | 2018-02-23 | 2024-01-17 | 同種固形臓器移植に対するドナー特異的寛容を促進する培養胸腺組織移植 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020543913A Active JP7499178B2 (ja) | 2018-02-23 | 2019-02-22 | 同種固形臓器移植に対するドナー特異的寛容を促進する培養胸腺組織移植 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12064452B2 (https=) |
| EP (2) | EP3755346B1 (https=) |
| JP (2) | JP7499178B2 (https=) |
| KR (2) | KR102805282B1 (https=) |
| CN (1) | CN112074277A (https=) |
| AU (1) | AU2019225151B2 (https=) |
| BR (1) | BR112020016614A2 (https=) |
| CA (1) | CA3089593A1 (https=) |
| IL (1) | IL276706A (https=) |
| MX (1) | MX2020008590A (https=) |
| SG (1) | SG11202007498YA (https=) |
| WO (1) | WO2019165197A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021034650A1 (en) | 2019-08-19 | 2021-02-25 | Duke University & Medical Center | Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use |
| CN115287262B (zh) * | 2022-01-28 | 2024-04-02 | 浙江中医药大学 | 一种胸腺类器官微球及其制备方法与应用 |
| WO2024042488A1 (en) | 2022-08-24 | 2024-02-29 | Enzyvant Therapeutics Gmbh | Thymic exosome assays, and methods of producing t cell depleted thymus tissue and uses thereof |
| WO2025068989A1 (en) | 2023-09-29 | 2025-04-03 | Enzyvant Therapeutics Gmbh | Device for cultivating and transporting biological tissue |
| JP7627920B1 (ja) | 2023-12-11 | 2025-02-07 | 浩 宮内 | 移植材料の評価方法 |
| CN118203653A (zh) * | 2024-02-06 | 2024-06-18 | 同济大学 | 一种利用胸腺疫苗降低或消除同种异体移植排斥的方法 |
| WO2025226936A1 (en) * | 2024-04-24 | 2025-10-30 | Revivicor, Inc. | Donor-specific tolerance-inducing regimens for xenotransplantation |
| WO2025240817A1 (en) * | 2024-05-17 | 2025-11-20 | The Trustees Of Columbia University In The City Of New York | Thymoliver and methods of constructing thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624823A (en) | 1991-11-22 | 1997-04-29 | The General Hospital Corporation | DNA encoding procine interleukin-10 |
| EP0667792A1 (en) | 1991-11-22 | 1995-08-23 | The General Hospital Corporation | Specific tolerance in transplantation |
| ATE215375T1 (de) | 1992-01-08 | 2002-04-15 | Gen Hospital Corp | Induzierte toleranz gegen transplantate |
| US5658564A (en) | 1992-02-19 | 1997-08-19 | The General Hospital Corporation | Xenograft thymus |
| US6911220B1 (en) * | 1992-02-19 | 2005-06-28 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US5876708A (en) | 1992-02-19 | 1999-03-02 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US5766944A (en) * | 1996-12-31 | 1998-06-16 | Ruiz; Margaret Eileen | T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments |
| AUPP977899A0 (en) | 1999-04-15 | 1999-05-13 | Monash University | Improvement of t cell mediated immunity |
| US20040096971A1 (en) * | 2000-12-22 | 2004-05-20 | Blackburn Catherine Clare | Thymic epithelial progenitor cells and uses thereof |
| US20040086508A1 (en) * | 2001-06-05 | 2004-05-06 | Advanced Biotherapy, Inc. | Treatment of organ transplant rejection |
| US7037900B2 (en) | 2001-10-12 | 2006-05-02 | Supergen, Inc. | Composition and method for treating graft-versus-host disease |
| US7402432B2 (en) * | 2003-12-12 | 2008-07-22 | The Brigham And Women's Hospital, Inc. | Process for producing T lymphocytes |
| CA2580271A1 (en) * | 2004-10-05 | 2006-04-20 | Genentech, Inc. | Method for treating vasculitis |
| WO2006107601A2 (en) * | 2005-04-06 | 2006-10-12 | Duke University | Parathyroid and thymus transplantation in digeorge syndrome subjects |
| EP1993573A2 (en) * | 2006-01-13 | 2008-11-26 | Renovar, Inc. | Systems and methods for monitoring immune responses and predicting outcomes in transplant recipients |
| US20080131441A1 (en) | 2006-09-26 | 2008-06-05 | Manikkam Suthanthiran | Methods of Using FOXP3 Levels to Predict the Outcome of Organs Undergoing Acute Rejection |
| US9176122B2 (en) | 2008-03-24 | 2015-11-03 | University Of South Florida | Biomarkers for predicting response to immunosuppressive therapy |
| JP2013511554A (ja) | 2009-11-23 | 2013-04-04 | パラティン テクノロジーズ，インコーポレイテッド | メラノコルチン−１受容体特異的線状ペプチド |
| JP2014503217A (ja) * | 2010-12-31 | 2014-02-13 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | マウスにおける自己ｔ細胞の生成 |
| US8637038B2 (en) * | 2011-04-12 | 2014-01-28 | Rigel Pharmaceuticals, Inc. | Methods for inhibiting allograft rejection |
| WO2015056103A2 (en) * | 2013-10-15 | 2015-04-23 | Regeneron Pharmaceuticals, Inc. | High resolution allele identification |
| US12090142B2 (en) | 2018-02-22 | 2024-09-17 | Board Of Regents, The University Of Texas System | Combination therapy for the treatment of cancer |
| WO2020010067A1 (en) | 2018-07-06 | 2020-01-09 | Enzyvant Therapeutics, Inc. | Tissue potency determination through quantitative histomorphology analysis |
-
2019
- 2019-02-22 EP EP19757113.6A patent/EP3755346B1/en active Active
- 2019-02-22 AU AU2019225151A patent/AU2019225151B2/en active Active
- 2019-02-22 SG SG11202007498YA patent/SG11202007498YA/en unknown
- 2019-02-22 KR KR1020207023608A patent/KR102805282B1/ko active Active
- 2019-02-22 WO PCT/US2019/019137 patent/WO2019165197A1/en not_active Ceased
- 2019-02-22 CA CA3089593A patent/CA3089593A1/en active Pending
- 2019-02-22 BR BR112020016614-6A patent/BR112020016614A2/pt unknown
- 2019-02-22 KR KR1020257014739A patent/KR20250071282A/ko active Pending
- 2019-02-22 JP JP2020543913A patent/JP7499178B2/ja active Active
- 2019-02-22 MX MX2020008590A patent/MX2020008590A/es unknown
- 2019-02-22 CN CN201980013250.XA patent/CN112074277A/zh active Pending
- 2019-02-22 EP EP24216970.4A patent/EP4545145A3/en active Pending
-
2020
- 2020-08-13 IL IL276706A patent/IL276706A/en unknown
-
2021
- 2021-09-27 US US17/486,045 patent/US12064452B2/en active Active
-
2024
- 2024-01-17 JP JP2024005418A patent/JP2024041955A/ja active Pending
- 2024-07-08 US US18/766,244 patent/US20250114402A1/en active Pending
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