|
US20020102257A1
(en)
|
1998-09-21 |
2002-08-01 |
Leslie Sid Johnson |
Human-murine chimeric antibodies against respiratory syncytial virus
|
|
US5604090A
(en)
|
1994-06-06 |
1997-02-18 |
Fred Hutchinson Cancer Research Center |
Method for increasing transduction of cells by adeno-associated virus vectors
|
|
WO2001059142A1
(en)
*
|
2000-02-09 |
2001-08-16 |
Medimmune, Inc. |
Antibody gene therapy with adeno-associated viral vectors
|
|
US20020106729A1
(en)
*
|
2000-07-03 |
2002-08-08 |
Bleck Gregory T. |
Expression vectors
|
|
AU7658101A
(en)
|
2000-07-28 |
2002-02-13 |
Cytos Biotechnology Ag |
Compositions for inducing self-specific anti-ige antibodies and uses thereof
|
|
DE10113776B4
(de)
*
|
2001-03-21 |
2012-08-09 |
"Iba Gmbh" |
Isoliertes streptavidinbindendes, kompetitiv eluierbares Peptid, dieses umfassendes Fusionspeptid, dafür codierende Nukleinsäure, Expressionsvektor, Verfahren zur Herstellung eines rekombinanten Fusionsproteins und Verfahren zum Nachweis und/oder zur Gewinnung des Fusionsproteins
|
|
US7696322B2
(en)
*
|
2003-07-28 |
2010-04-13 |
Catalent Pharma Solutions, Inc. |
Fusion antibodies
|
|
WO2006115800A2
(en)
*
|
2005-04-15 |
2006-11-02 |
The Regents Of The University Of California |
Enhanced wound healing utilizing an anti-her2 antibody coupled to a tnf alpha
|
|
JP2009532027A
(ja)
*
|
2006-03-28 |
2009-09-10 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
抗igf−1r抗体およびその使用
|
|
AU2010232414A1
(en)
|
2009-04-03 |
2011-10-13 |
Duke University |
Mouse models
|
|
ES2948572T3
(es)
*
|
2009-07-08 |
2023-09-14 |
Kymab Ltd |
Modelos de roedores y moléculas terapéuticas
|
|
WO2011047442A1
(en)
*
|
2009-10-23 |
2011-04-28 |
Garvan Institute Of Medical Research |
Modified variable domain molecules and methods for producing and using same
|
|
CA2786664C
(en)
*
|
2010-01-08 |
2020-03-10 |
Immusoft Corporation |
Vectors and methods for transducing b cells
|
|
TWI539963B
(zh)
|
2010-07-09 |
2016-07-01 |
庫賽爾荷蘭公司 |
抗-人類呼吸道融合性病毒(rsv)抗體及其使用方法
|
|
US8637035B2
(en)
|
2010-07-16 |
2014-01-28 |
Academia Sinica |
Anti-dengue virus antibodies
|
|
EP2663334A4
(en)
|
2011-01-10 |
2016-01-13 |
Univ Emory |
ANTIBODIES AGAINST INFLUENZA
|
|
ES2857734T3
(es)
|
2011-08-23 |
2021-09-29 |
Roche Glycart Ag |
Moléculas de unión a antígeno activadoras de linfocitos T biespecíficas
|
|
GB201122047D0
(en)
*
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
EP2825670A4
(en)
|
2012-03-16 |
2015-11-04 |
Univ Rochester |
METHODS FOR PREDICTING THE CLINICAL OUTCOME OF CHRONIC LYMPHOCYTIC LEUKEMIA
|
|
WO2013148256A2
(en)
|
2012-03-27 |
2013-10-03 |
Dana-Farber Cancer Institute, Inc. |
Compositions, kits, and methods for the generation of immunoglobulin sequences
|
|
CN105188767A
(zh)
|
2012-07-25 |
2015-12-23 |
布罗德研究所有限公司 |
可诱导的dna结合蛋白和基因组干扰工具及其应用
|
|
BR112015013784A2
(pt)
|
2012-12-12 |
2017-07-11 |
Massachusetts Inst Technology |
aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas
|
|
CN105658796B
(zh)
|
2012-12-12 |
2021-10-26 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
ES2701749T3
(es)
|
2012-12-12 |
2019-02-25 |
Broad Inst Inc |
Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
|
|
EP3064585B1
(en)
|
2012-12-12 |
2020-02-05 |
The Broad Institute, Inc. |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
ES2536353T3
(es)
|
2012-12-12 |
2015-05-22 |
The Broad Institute, Inc. |
Ingeniería de sistemas, métodos y composiciones de guía optimizadas para manipulación de secuencias
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
CN113355357B
(zh)
|
2012-12-12 |
2024-12-03 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
US11332719B2
(en)
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US10993420B2
(en)
*
|
2013-03-15 |
2021-05-04 |
Erasmus University Medical Center |
Production of heavy chain only antibodies in transgenic mammals
|
|
EP3011030B1
(en)
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
JP6625971B2
(ja)
|
2013-06-17 |
2019-12-25 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のためのタンデムガイド系、方法および組成物の送達、エンジニアリングおよび最適化
|
|
WO2014204723A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions
|
|
CN105683379A
(zh)
|
2013-06-17 |
2016-06-15 |
布罗德研究所有限公司 |
用于对有丝分裂后细胞的疾病和障碍进行靶向和建模的系统、方法和组合物的递送、工程化和优化
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
DK3011031T3
(da)
|
2013-06-17 |
2020-12-21 |
Broad Inst Inc |
Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi
|
|
KR20250012194A
(ko)
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
US9914759B2
(en)
|
2013-07-19 |
2018-03-13 |
Vib Vzw |
Targeted modified TNF family members
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
KR20160089530A
(ko)
*
|
2013-12-12 |
2016-07-27 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Hbv 및 바이러스 질병 및 질환을 위한 crisprcas 시스템 및 조성물의 전달,용도 및 치료적 적용
|
|
WO2015089351A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
WO2015089427A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes
|
|
JP2017501149A
(ja)
|
2013-12-12 |
2017-01-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
粒子送達構成成分を用いた障害及び疾患の標的化のためのcrispr−cas系及び組成物の送達、使用及び治療適用
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
IL289736B2
(en)
|
2013-12-12 |
2025-09-01 |
Massachusetts Inst Technology |
Administration, use and therapeutic applications of CRISPR–Cas gene editing systems and gene editing preparations
|
|
EP3102589A1
(en)
|
2014-02-04 |
2016-12-14 |
Biogen MA Inc. |
Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
|
|
US9512204B2
(en)
|
2014-03-31 |
2016-12-06 |
Board Of Regents, The University Of Texas System |
Humanized pertussis antibodies and uses thereof
|
|
EP3230457B1
(en)
*
|
2014-12-09 |
2021-06-30 |
New York University |
Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
|
|
AU2016243052C1
(en)
*
|
2015-04-03 |
2022-11-24 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of B-cells
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
US12110490B2
(en)
|
2015-12-18 |
2024-10-08 |
The Broad Institute, Inc. |
CRISPR enzymes and systems
|
|
US20190264186A1
(en)
|
2016-01-22 |
2019-08-29 |
The Broad Institute Inc. |
Crystal structure of crispr cpf1
|